5DHB
| Cooperativity and Downstream Binding in RNA Replication | 分子名称: | GUANOSINE-5'-MONOPHOSPHATE, RNA (5'-R(*(LCC)P*(TLN)P*(LCG)P*UP*AP*CP*A)-3') | 著者 | Zhang, W, Fahrenbach, A.C, Tam, C.P, Szostak, J.W. | 登録日 | 2015-08-30 | 公開日 | 2016-12-07 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Unusual Base-Pairing Interactions in Monomer-Template Complexes. ACS Cent Sci, 2, 2016
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5DHC
| Cooperativity and Downstream Binding in RNA Replication | 分子名称: | GUANOSINE-5'-MONOPHOSPHATE, MAGNESIUM ION, RNA (5'-R(*(LCC)P*(LCC)P*(LCA)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*U)-3') | 著者 | Zhang, W, Fahrenbach, A.C, Tam, C.P, Szostak, J.W. | 登録日 | 2015-08-30 | 公開日 | 2016-12-07 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Unusual Base-Pairing Interactions in Monomer-Template Complexes. ACS Cent Sci, 2, 2016
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5HBW
| RNA primer-template complex with 2-methylimidazole-activated monomer analogue | 分子名称: | RNA (5'-R(*(LCC)P*(TLN)P*(LCG)P*UP*AP*CP*A)-3'), [(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-(3-methyl-1~{H}-pyrazol-4-yl)phosphinic acid | 著者 | Zhang, W, Tam, C.P, Szostak, J.W. | 登録日 | 2016-01-03 | 公開日 | 2016-12-07 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Unusual Base-Pairing Interactions in Monomer-Template Complexes. ACS Cent Sci, 2, 2016
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5HBX
| RNA primer-template complex with 2-methylimidazole-activated monomer analogue-2 binding sites | 分子名称: | RNA (5'-R(*(LCC)P*(LCC)P*(LCA)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*U)-3'), [(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-(3-methyl-1~{H}-pyrazol-4-yl)phosphinic acid | 著者 | Zhang, W, Tam, C.P, Szostak, J.W. | 登録日 | 2016-01-03 | 公開日 | 2016-12-07 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Unusual Base-Pairing Interactions in Monomer-Template Complexes. ACS Cent Sci, 2, 2016
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5HBY
| RNA primer-template complex with 2-methylimidazole-activated monomer analogue-3 binding sites | 分子名称: | MAGNESIUM ION, RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*C)-3'), [(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-(3-methyl-1~{H}-pyrazol-4-yl)phosphinic acid | 著者 | Zhang, W, Tam, C.P, Wang, J, Szostak, J.W. | 登録日 | 2016-01-03 | 公開日 | 2016-12-07 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.18 Å) | 主引用文献 | Unusual Base-Pairing Interactions in Monomer-Template Complexes. ACS Cent Sci, 2, 2016
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7KUK
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7KUL
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7KUP
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7KUM
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7KUN
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7KUO
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7LNE
| ANA modification at 3' end of RNA primer complex with guanosine dinucleotide ligand G(5')ppp(5')G | 分子名称: | 4-AMINO-1-[(1S,3R,4R,7S)-7-HYDROXY-1-(HYDROXYMETHYL)-2,5-DIOXABICYCLO[2.2.1]HEPT-3-YL]-5-METHYLPYRIMIDIN-2(1H)-ONE, DIGUANOSINE-5'-TRIPHOSPHATE, GUANINE ARABINOSE-5'-PHOSPHATE, ... | 著者 | Fang, Z, Giurgiu, C, Szostak, J.W. | 登録日 | 2021-02-07 | 公開日 | 2021-09-08 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.53 Å) | 主引用文献 | Structure-Activity Relationships in Nonenzymatic Template-Directed RNA Synthesis. Angew.Chem.Int.Ed.Engl., 60, 2021
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7LNG
| TNA modification at 3' end of RNA primer complex with guanosine dinucleotide ligand G(5')ppp(5')G | 分子名称: | 2-azanyl-9-[(2~{R},3~{R},4~{S})-3-oxidanyl-4-[oxidanyl-bis(oxidanylidene)-$l^{6}-phosphanyl]oxy-oxolan-2-yl]-1~{H}-purin-6-one, 4-AMINO-1-[(1S,3R,4R,7S)-7-HYDROXY-1-(HYDROXYMETHYL)-2,5-DIOXABICYCLO[2.2.1]HEPT-3-YL]-5-METHYLPYRIMIDIN-2(1H)-ONE, DIGUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Fang, Z, Giurgiu, C, Szostak, J.W. | 登録日 | 2021-02-07 | 公開日 | 2021-09-08 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure-Activity Relationships in Nonenzymatic Template-Directed RNA Synthesis. Angew.Chem.Int.Ed.Engl., 60, 2021
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7LNF
| 3'-deoxy modification at 3' end of RNA primer complex with guanosine dinucleotide ligand G(5')ppp(5')G | 分子名称: | 3'-deoxy-guanosine 5'-monophosphate, 4-AMINO-1-[(1S,3R,4R,7S)-7-HYDROXY-1-(HYDROXYMETHYL)-2,5-DIOXABICYCLO[2.2.1]HEPT-3-YL]-5-METHYLPYRIMIDIN-2(1H)-ONE, COBALT (II) ION, ... | 著者 | Fang, Z, Giurgiu, C, Szostak, J.W. | 登録日 | 2021-02-07 | 公開日 | 2021-09-08 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.652 Å) | 主引用文献 | Structure-Activity Relationships in Nonenzymatic Template-Directed RNA Synthesis. Angew.Chem.Int.Ed.Engl., 60, 2021
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2P0X
| solution structure of a non-biological ATP-binding protein | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, ZINC ION, abiotic ATP-binding, ... | 著者 | Mansy, S.S, Szostak, J.W, Chaput, J.C. | 登録日 | 2007-03-01 | 公開日 | 2007-08-07 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure and Evolutionary Analysis of a Non-biological ATP-binding Protein J.Mol.Biol., 371, 2007
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2P09
| Structural Insights into the Evolution of a Non-Biological Protein | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, PENTAETHYLENE GLYCOL, ... | 著者 | Smith, M, Rosenow, M, Wang, M, Allen, J.P, Szostak, J.W, Chaput, J.C. | 登録日 | 2007-02-28 | 公開日 | 2007-06-05 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Structural insights into the evolution of a non-biological protein: importance of surface residues in protein fold optimization. PLoS ONE, 2, 2007
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2P05
| Structural Insights into the Evolution of a Non-Biological Protein | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, PENTAETHYLENE GLYCOL, ... | 著者 | Smith, M, Rosenow, M, Wang, M, Allen, J.P, Szostak, J.W, Chaput, J.C. | 登録日 | 2007-02-28 | 公開日 | 2007-06-05 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural insights into the evolution of a non-biological protein: importance of surface residues in protein fold optimization. PLoS ONE, 2, 2007
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4MSR
| RNA 10mer duplex with six 2'-5'-linkages | 分子名称: | RNA 10mer duplex with six 2'-5'-linkages, STRONTIUM ION | 著者 | Sheng, J, Li, L, Engelhart, A.E, Gan, J, Wang, J, Szostak, J.W. | 登録日 | 2013-09-18 | 公開日 | 2014-02-12 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Structural insights into the effects of 2'-5' linkages on the RNA duplex. Proc.Natl.Acad.Sci.USA, 111, 2014
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4MS9
| Native RNA-10mer Structure: ccggcgccgg | 分子名称: | Native RNA duplex 10mer, STRONTIUM ION | 著者 | Sheng, J, Li, L, Engelhart, A.E, Gan, J, Wang, J, Szostak, J.W. | 登録日 | 2013-09-18 | 公開日 | 2014-02-12 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.32 Å) | 主引用文献 | Structural insights into the effects of 2'-5' linkages on the RNA duplex. Proc.Natl.Acad.Sci.USA, 111, 2014
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4MSB
| RNA 10mer duplex with two 2'-5'-linkages | 分子名称: | RNA 10mer duplex with two 2'-5'-linkages, STRONTIUM ION | 著者 | Sheng, J, Li, L, Engelhart, A.E, Gan, J, Wang, J, Szostak, J.W. | 登録日 | 2013-09-18 | 公開日 | 2014-02-12 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Structural insights into the effects of 2'-5' linkages on the RNA duplex. Proc.Natl.Acad.Sci.USA, 111, 2014
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8SCN
| Bst DNA polymerase I Large Fragment mutant F710Y/D598A with 3'-amino primer, dGTP, and calcium time-resolved 24h (Product State) | 分子名称: | CALCIUM ION, DIPHOSPHATE, DNA polymerase I, ... | 著者 | Fang, Z, Lelyveld, V.S, Szostak, J.W. | 登録日 | 2023-04-05 | 公開日 | 2023-10-25 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Trivalent rare earth metal cofactors confer rapid NP-DNA polymerase activity. Science, 382, 2023
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8SCJ
| Bst DNA polymerase I Large Fragment mutant F710Y/D598A with 3'-amino primer, dGTP, and calcium time-resolved 2h | 分子名称: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ... | 著者 | Fang, Z, Lelyveld, V.S, Szostak, J.W. | 登録日 | 2023-04-05 | 公開日 | 2023-10-25 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | 主引用文献 | Trivalent rare earth metal cofactors confer rapid NP-DNA polymerase activity. Science, 382, 2023
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8SCS
| Bst DNA polymerase I Large Fragment wildtype D598A with 3'-amino primer, dGTP, and calcium time-resolved 8h | 分子名称: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ... | 著者 | Fang, Z, Lelyveld, V.S, Szostak, J.W. | 登録日 | 2023-04-05 | 公開日 | 2023-10-25 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Trivalent rare earth metal cofactors confer rapid NP-DNA polymerase activity. Science, 382, 2023
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8SCU
| Bst DNA polymerase I Large Fragment wildtype D598A with 3'-amino primer, dGTP, and calcium time-resolved 48h (Product State) | 分子名称: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ... | 著者 | Fang, Z, Lelyveld, V.S, Szostak, J.W. | 登録日 | 2023-04-05 | 公開日 | 2023-10-25 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | 主引用文献 | Trivalent rare earth metal cofactors confer rapid NP-DNA polymerase activity. Science, 382, 2023
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8SCI
| Bst DNA polymerase I Large Fragment mutant F710Y/D598A with 3'-amino primer, dGTP, and calcium time-resolved 1h | 分子名称: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ... | 著者 | Fang, Z, Lelyveld, V.S, Szostak, J.W. | 登録日 | 2023-04-05 | 公開日 | 2023-10-25 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.67 Å) | 主引用文献 | Trivalent rare earth metal cofactors confer rapid NP-DNA polymerase activity. Science, 382, 2023
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