7KUM

LNA modification at 3' end of RNA primer complex with guanosine dinucleotide ligand G(5')ppp(5')G

Summary for 7KUM

• Entry DOI: 10.2210/pdb7kum/pdb
• Descriptor: 5'-R((LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*(LCG)-3', DIGUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: rna, nonenzymatic rna extension
• Biological source: synthetic construct
• Total number of polymer chains: 2
• Total formula weight: 10563.70

Authors

Fang, Z.,Giurgiu, C.,Szostak, J.W. (deposition date: 2020-11-25, release date: 2021-09-08, Last modification date: 2023-10-18)

• Primary citation: Giurgiu, C.,Fang, Z.,Aitken, H.R.M.,Kim, S.C.,Pazienza, L.,Mittal, S.,Szostak, J.W.; Structure-Activity Relationships in Nonenzymatic Template-Directed RNA Synthesis.; Angew.Chem.Int.Ed.Engl., 60:22925-22932, 2021; PubMed: 34428345; DOI: 10.1002/anie.202109714

Experimental method

X-RAY DIFFRACTION (1.714 Å)