8OZ7
 
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8P00
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7R08
 | | Abortive infection DNA polymerase Abi-P2 | | 分子名称: | Reverse transcriptase | | 著者 | Gapinska, M.A, Figiel, M, Czarnocki Cieciura, M, Nowotny, M, Zajko, W. | | 登録日 | 2022-02-01 | | 公開日 | 2022-09-07 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Mechanism of protein-primed template-independent DNA synthesis by Abi polymerases.
Nucleic Acids Res., 50, 2022
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7R06
 | | Abortive infection DNA polymerase AbiK from Lactococcus lactis | | 分子名称: | AbiK, DNA (5'-D(*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*C)-3') | | 著者 | Figiel, M, Nowotny, M, Gapinska, M, Czarnocki-Cieciura, M, Zajko, W. | | 登録日 | 2022-02-01 | | 公開日 | 2022-09-07 | | 最終更新日 | 2022-10-05 | | 実験手法 | ELECTRON MICROSCOPY (2.27 Å) | | 主引用文献 | Mechanism of protein-primed template-independent DNA synthesis by Abi polymerases.
Nucleic Acids Res., 50, 2022
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7R07
 | | Abortive infection DNA polymerase AbiK from Lactococcus lactis | | 分子名称: | AbiK, DNA (5'-D(*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*C)-3'), MAGNESIUM ION | | 著者 | Figiel, M, Gapinska, M, Czarnocki-Cieciura, M, Zajko, W, Nowotny, M. | | 登録日 | 2022-02-01 | | 公開日 | 2022-09-07 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Mechanism of protein-primed template-independent DNA synthesis by Abi polymerases.
Nucleic Acids Res., 50, 2022
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6F4A
 | | Yeast mitochondrial RNA degradosome complex mtEXO | | 分子名称: | Exoribonuclease II, mitochondrial, RNA (5'-R(P*AP*GP*AP*UP*AP*C)-3'), ... | | 著者 | Razew, M, Nowak, E, Nowotny, M. | | 登録日 | 2017-11-29 | | 公開日 | 2018-01-17 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (3.55 Å) | | 主引用文献 | Structural analysis of mtEXO mitochondrial RNA degradosome reveals tight coupling of nuclease and helicase components.
Nat Commun, 9, 2018
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7Z0Z
 | | Abortive infection DNA polymerase AbiK from Lactococcus lactis, Y44F variant | | 分子名称: | AbiK | | 著者 | Figiel, M, Gapinska, M, Czarnocki-Cieciura, M, Zajko, W, Nowotny, M. | | 登録日 | 2022-02-24 | | 公開日 | 2022-09-07 | | 最終更新日 | 2022-10-05 | | 実験手法 | ELECTRON MICROSCOPY (2.68 Å) | | 主引用文献 | Mechanism of protein-primed template-independent DNA synthesis by Abi polymerases.
Nucleic Acids Res., 50, 2022
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6F3H
 | | Crystal structure of Dss1 exoribonuclease active site mutant D477N from Candida glabrata | | 分子名称: | Exoribonuclease II, mitochondrial, MAGNESIUM ION, ... | | 著者 | Razew, M, Nowak, E, Nowotny, M. | | 登録日 | 2017-11-28 | | 公開日 | 2018-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.703 Å) | | 主引用文献 | Structural analysis of mtEXO mitochondrial RNA degradosome reveals tight coupling of nuclease and helicase components.
Nat Commun, 9, 2018
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8R42
 | | Structure of CHI3L1 in complex with inhibititor 2 | | 分子名称: | 1,2-ETHANEDIOL, 2-[4-[(2~{R})-2-[(4-chlorophenyl)methyl]pyrrolidin-1-yl]piperidin-1-yl]pyridine, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Nowak, E, Napiorkowska-Gromadzka, A, Nowotny, M. | | 登録日 | 2023-11-10 | | 公開日 | 2024-03-13 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | | 主引用文献 | Structure-Based Discovery of High-Affinity Small Molecule Ligands and Development of Tool Probes to Study the Role of Chitinase-3-Like Protein 1.
J.Med.Chem., 67, 2024
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4LD0
 | | T. thermophilus RuvC in complex with Holliday junction substrate | | 分子名称: | Crossover junction endodeoxyribonuclease RuvC, DNA 11-MER, DNA 13-MER, ... | | 著者 | Gorecka, K.M, Komorowska, W, Nowotny, M. | | 登録日 | 2013-06-24 | | 公開日 | 2013-09-04 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (3.75 Å) | | 主引用文献 | Crystal structure of RuvC resolvase in complex with Holliday junction substrate.
Nucleic Acids Res., 41, 2013
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1RL1
 | | Solution structure of human Sgt1 CS domain | | 分子名称: | Suppressor of G2 allele of SKP1 homolog | | 著者 | Lee, Y.-T, Jacob, J, Michowski, W, Nowotny, M, Kuznicki, J, Chazin, W.J. | | 登録日 | 2003-11-24 | | 公開日 | 2004-05-04 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Human Sgt1 Binds HSP90 through the CHORD-Sgt1 Domain and Not the Tetratricopeptide Repeat Domain
J.Biol.Chem., 279, 2004
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4XLG
 | | C. glabrata Slx1 in complex with Slx4CCD. | | 分子名称: | CHLORIDE ION, Structure-specific endonuclease subunit SLX1, Structure-specific endonuclease subunit SLX4, ... | | 著者 | Gaur, V, Wyatt, H.D.M, Komorowska, W, Szczepanowski, R.H, de Sanctis, D, Gorecka, K.M, West, S.C, Nowotny, M. | | 登録日 | 2015-01-13 | | 公開日 | 2015-03-25 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | | 主引用文献 | Structural and Mechanistic Analysis of the Slx1-Slx4 Endonuclease.
Cell Rep, 10, 2015
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4XM5
 | | C. glabrata Slx1. | | 分子名称: | CHLORIDE ION, Structure-specific endonuclease subunit SLX1, ZINC ION | | 著者 | Gaur, V, Wyatt, H.D.M, Komorowska, W, Szczepanowski, R.H, de Sanctis, D, Gorecka, K.M, West, S.C, Nowotny, M. | | 登録日 | 2015-01-14 | | 公開日 | 2015-03-25 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | | 主引用文献 | Structural and Mechanistic Analysis of the Slx1-Slx4 Endonuclease.
Cell Rep, 10, 2015
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7O0H
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7O0G
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7ZVN
 | | Crystal structure of human Annexin A2 in complex with full phosphorothioate 5-10 2'-methoxyethyl DNA gapmer antisense oligonucleotide solved at 1.87 A resolution | | 分子名称: | 2'-methoxyethyl DNA gapmer antisense oligonucleotide, Annexin A2, CALCIUM ION, ... | | 著者 | Hyjek-Skladanowska, M, Anderson, B, Mykhaylyk, V, Orr, C, Wagner, A, Skowronek, K, Seth, P, Nowotny, M. | | 登録日 | 2022-05-16 | | 公開日 | 2022-09-14 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | | 主引用文献 | Structures of annexin A2-PS DNA complexes show dominance of hydrophobic interactions in phosphorothioate binding.
Nucleic Acids Res., 51, 2023
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7ZVX
 | | Crystal structure of human Annexin A2 in complex with full phosphorothioate 5-10 2'-methoxyethyl DNA gapmer antisense oligonucleotide solved at 2.4 A resolution | | 分子名称: | 1,2-ETHANEDIOL, 2'-methoxyethyl DNA gapmer antisense oligonucleotide, Annexin A2, ... | | 著者 | Hyjek-Skladanowska, M, Anderson, B, Mykhaylyk, V, Orr, C, Wagner, A, Skowronek, K, Seth, P, Nowotny, M. | | 登録日 | 2022-05-17 | | 公開日 | 2022-09-14 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structures of annexin A2-PS DNA complexes show dominance of hydrophobic interactions in phosphorothioate binding.
Nucleic Acids Res., 51, 2023
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8R41
 | | Structure of CHI3L1 in complex with inhibitor 1 | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BROMIDE ION, ... | | 著者 | Nowak, E, Napiorkowska-Gromadzka, A, Nowotny, M. | | 登録日 | 2023-11-10 | | 公開日 | 2024-03-13 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Structure-Based Discovery of High-Affinity Small Molecule Ligands and Development of Tool Probes to Study the Role of Chitinase-3-Like Protein 1.
J.Med.Chem., 67, 2024
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8R4X
 | | Structure of Chitinase-3-like protein 1 in complex with inhibitor 30 | | 分子名称: | (2~{S},5~{S})-4-[1-(4-chloranylpyridin-2-yl)piperidin-4-yl]-5-[(4-chlorophenyl)methyl]-2-methyl-morpholine, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Nowak, E, Napiorkowska-Gromadzka, A, Nowotny, M. | | 登録日 | 2023-11-14 | | 公開日 | 2024-03-13 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | | 主引用文献 | Structure-Based Discovery of High-Affinity Small Molecule Ligands and Development of Tool Probes to Study the Role of Chitinase-3-Like Protein 1.
J.Med.Chem., 67, 2024
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8AUP
 | | Structure of hARG1 with a novel inhibitor. | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-[(1~{R},3~{R},4~{S})-3-azanyl-3-carboxy-4-[(dimethylamino)methyl]cyclohexyl]ethyl-$l^{3}-oxidanyl-bis(oxidanyl)boron, Arginase-1, ... | | 著者 | Napiorkowska-Gromadzka, A, Nowak, E, Nowotny, M. | | 登録日 | 2022-08-25 | | 公開日 | 2023-03-29 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | | 主引用文献 | Arginase 1/2 Inhibitor OATD-02: From Discovery to First-in-man Setup in Cancer Immunotherapy.
Mol.Cancer Ther., 22, 2023
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6S16
 | | T. thermophilus RuvC in complex with Holliday junction substrate | | 分子名称: | CHLORIDE ION, Crossover junction endodeoxyribonuclease RuvC, DNA (33-MER), ... | | 著者 | Gorecka, K.M, Krepl, M, Szlachcic, A, Poznanski, J, Sponer, J, Nowotny, M. | | 登録日 | 2019-06-18 | | 公開日 | 2019-09-25 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (3.409 Å) | | 主引用文献 | RuvC uses dynamic probing of the Holliday junction to achieve sequence specificity and efficient resolution.
Nat Commun, 10, 2019
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6SEH
 | | Recognition and processing of branched DNA substrates by Slx1-Slx4 nuclease | | 分子名称: | Structure-specific endonuclease subunit SLX1, Structure-specific endonuclease subunit SLX4, ZINC ION | | 著者 | Gaur, V, Zajko, W, Nirwal, S, Szlachcic, A, Gapinska, M, Nowotny, M. | | 登録日 | 2019-07-30 | | 公開日 | 2019-09-25 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | | 主引用文献 | Recognition and processing of branched DNA substrates by Slx1-Slx4 nuclease.
Nucleic Acids Res., 47, 2019
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6SEI
 | | Recognition and processing of branched DNA substrates by Slx1-Slx4 nuclease | | 分子名称: | CALCIUM ION, DNA (32-MER), Structure-specific endonuclease subunit SLX1, ... | | 著者 | Gaur, V, Zajko, W, Nirwal, S, Szlachcic, A, Gapinska, M, Nowotny, M. | | 登録日 | 2019-07-30 | | 公開日 | 2019-09-25 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | | 主引用文献 | Recognition and processing of branched DNA substrates by Slx1-Slx4 nuclease.
Nucleic Acids Res., 47, 2019
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8A8J
 | | Complex of RecF and DNA from Thermus thermophilus. | | 分子名称: | DNA replication and repair protein RecF, MAGNESIUM ION, Oligo1, ... | | 著者 | Nirwal, S, Czarnocki-Cieciura, M, Chaudhary, A, Zajko, W, Skowronek, K, Chamera, S, Figiel, M, Nowotny, M. | | 登録日 | 2022-06-23 | | 公開日 | 2023-04-26 | | 最終更新日 | 2023-05-31 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Mechanism of RecF-RecO-RecR cooperation in bacterial homologous recombination.
Nat.Struct.Mol.Biol., 30, 2023
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8A93
 | | Complex of RecF-RecR-DNA from Thermus thermophilus. | | 分子名称: | DNA replication and repair protein RecF, MAGNESIUM ION, Oligo1, ... | | 著者 | Nirwal, S, Czarnocki-Cieciura, M, Chaudhary, A, Zajko, W, Skowronek, K, Chamera, S, Figiel, M, Nowotny, M. | | 登録日 | 2022-06-27 | | 公開日 | 2023-04-26 | | 最終更新日 | 2023-05-31 | | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | | 主引用文献 | Mechanism of RecF-RecO-RecR cooperation in bacterial homologous recombination.
Nat.Struct.Mol.Biol., 30, 2023
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