8J02
 
 | | Human KCNQ2(F104A)-CaM-PIP2-CBD complex in state II | | 分子名称: | Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 2, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, ... | | 著者 | Ma, D, Li, X, Guo, J. | | 登録日 | 2023-04-09 | | 公開日 | 2023-12-13 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Ligand activation mechanisms of human KCNQ2 channel.
Nat Commun, 14, 2023
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8J01
 | | Human KCNQ2-CaM in complex with CBD and PIP2 | | 分子名称: | Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 2, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, ... | | 著者 | Ma, D, Li, X, Guo, J. | | 登録日 | 2023-04-09 | | 公開日 | 2023-12-13 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Ligand activation mechanisms of human KCNQ2 channel.
Nat Commun, 14, 2023
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8YWY
 | | Crystal structure of SARS-Cov-2 main protease E166N mutant in complex with Bofutrelvir | | 分子名称: | 3C-like proteinase nsp5, ~{N}-[(2~{S})-3-cyclohexyl-1-oxidanylidene-1-[[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]propan-2-yl]-1~{H}-indole-2-carboxamide | | 著者 | Zhou, X.L, Wang, W.W, Zhang, J, Li, J. | | 登録日 | 2024-04-01 | | 公開日 | 2025-04-09 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Inhibitory efficacy and structural insights of Bofutrelvir against SARS-CoV-2 M pro mutants and MERS-CoV M pro.
Commun Biol, 8, 2025
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8YKJ
 | | Crystal structure of SARS-Cov-2 main protease in complex with X77 | | 分子名称: | N-(4-tert-butylphenyl)-N-[(1R)-2-(cyclohexylamino)-2-oxo-1-(pyridin-3-yl)ethyl]-1H-imidazole-4-carboxamide, Non-structural protein 11 | | 著者 | Zhou, X.L, Lin, C, Li, W.W, Zhang, J, Li, J. | | 登録日 | 2024-03-05 | | 公開日 | 2024-11-27 | | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | | 主引用文献 | Crystal structures of coronaviral main proteases in complex with the non-covalent inhibitor X77.
Int.J.Biol.Macromol., 276, 2024
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8YKL
 | | Crystal structure of MERS main protease in complex with X77 | | 分子名称: | N-(4-tert-butylphenyl)-N-[(1R)-2-(cyclohexylamino)-2-oxo-1-(pyridin-3-yl)ethyl]-1H-imidazole-4-carboxamide, ORF1a | | 著者 | Zhou, X.L, Lin, C, Zhang, J, Li, J. | | 登録日 | 2024-03-05 | | 公開日 | 2024-11-27 | | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | | 主引用文献 | Crystal structures of coronaviral main proteases in complex with the non-covalent inhibitor X77.
Int.J.Biol.Macromol., 276, 2024
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8YKK
 | | Crystal structure of SARS main protease in complex with X77 | | 分子名称: | 3C-like proteinase nsp5, N-(4-tert-butylphenyl)-N-[(1R)-2-(cyclohexylamino)-2-oxo-1-(pyridin-3-yl)ethyl]-1H-imidazole-4-carboxamide | | 著者 | Zhou, X.L, Lin, C, Zhang, J, Li, J. | | 登録日 | 2024-03-05 | | 公開日 | 2024-11-27 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal structures of coronaviral main proteases in complex with the non-covalent inhibitor X77.
Int.J.Biol.Macromol., 276, 2024
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8J03
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7VVP
 | | Crystal structure of SARS-Cov-2 main protease in complex with PF07304814 | | 分子名称: | 3C-like proteinase, [(3~{S})-3-[[(2~{S})-2-[(4-methoxy-1~{H}-indol-2-yl)carbonylamino]-4-methyl-pentanoyl]amino]-2-oxidanylidene-4-[(3~{R})-2-oxidanylidene-3,4-dihydropyrrol-3-yl]butyl] dihydrogen phosphate | | 著者 | Zhou, X.L, Zhong, F.L, Lin, C, Zeng, P, Zhang, J, Li, J. | | 登録日 | 2021-11-07 | | 公開日 | 2022-08-24 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | | 主引用文献 | Structural Basis of Main Proteases of Coronavirus Bound to Drug Candidate PF-07304814
J.Mol.Biol., 434, 2022
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8Y63
 | | Cryo-EM structure of the C20:0 ceramide-bound FPR2-Gi complex | | 分子名称: | Cer(d18:0/20:0), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Sun, J.P, Jiang, C.T, Kong, W, Yu, X, Cai, K, Guo, L.L. | | 登録日 | 2024-02-01 | | 公開日 | 2025-02-05 | | 最終更新日 | 2025-06-18 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Metabolic signaling of ceramides through the FPR2 receptor inhibits adipocyte thermogenesis.
Science, 388, 2025
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8Y62
 | | Cryo-EM structure of the C16:0 ceramide-bound FPR2-Gi complex | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | 著者 | Sun, J.P, Jiang, C.T, Kong, W, Yu, X, Cai, K, Guo, L.L. | | 登録日 | 2024-02-01 | | 公開日 | 2025-02-05 | | 最終更新日 | 2025-06-25 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Metabolic signaling of ceramides through the FPR2 receptor inhibits adipocyte thermogenesis.
Science, 388, 2025
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8JWH
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7WQH
 | | Crystal structure of HCoV-NL63 main protease with PF07304814 | | 分子名称: | 3C-like proteinase, [(3~{S})-3-[[(2~{S})-2-[(4-methoxy-1~{H}-indol-2-yl)carbonylamino]-4-methyl-pentanoyl]amino]-2-oxidanylidene-4-[(3~{R})-2-oxidanylidene-3,4-dihydropyrrol-3-yl]butyl] dihydrogen phosphate | | 著者 | Zhong, F.L, Zhou, X.L, Lin, C, Zeng, P, Li, J, Zhang, J. | | 登録日 | 2022-01-25 | | 公開日 | 2022-08-24 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | | 主引用文献 | Structural Basis of Main Proteases of Coronavirus Bound to Drug Candidate PF-07304814
J.Mol.Biol., 434, 2022
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8K6Q
 | | Crystal structure of HOIL-1L LTM domain | | 分子名称: | RanBP-type and C3HC4-type zinc finger-containing protein 1 | | 著者 | Yan, Z, Pan, L.F. | | 登録日 | 2023-07-25 | | 公開日 | 2024-07-03 | | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | | 主引用文献 | Mechanistic insights into the homo-dimerization of HOIL-1L and SHARPIN.
Biochem.Biophys.Res.Commun., 689, 2023
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8K6P
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7YK1
 | | Structural basis of human PRPS2 filaments | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ... | | 著者 | Lu, G.M, Hu, H.H, Liu, J.L. | | 登録日 | 2022-07-21 | | 公開日 | 2023-08-02 | | 最終更新日 | 2023-09-20 | | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | | 主引用文献 | Structural basis of human PRPS2 filaments.
Cell Biosci, 13, 2023
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7VFB
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7VFA
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8X8A
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8X8K
 | | Crystal structure of STBD1 CBM20 domain in complex with maltotetraose | | 分子名称: | GLYCEROL, Starch-binding domain-containing protein 1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | | 著者 | Zhang, Y.C, Pan, L.F. | | 登録日 | 2023-11-27 | | 公開日 | 2024-09-18 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Decoding the molecular mechanism of selective autophagy of glycogen mediated by autophagy receptor STBD1.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8WUR
 | | Crystal structure of SARS-Cov-2 main protease D48N mutant in complex with shikonin | | 分子名称: | 2-[(1R)-4-methyl-1-oxidanyl-pent-3-enyl]-5,8-bis(oxidanyl)naphthalene-1,4-dione, 3C-like proteinase nsp5 | | 著者 | Zhao, Z.Y, Li, W.W, Zhang, J, Li, J. | | 登録日 | 2023-10-21 | | 公開日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | | 主引用文献 | Structural Basis for the Inhibition of SARS-CoV-2 M pro D48N Mutant by Shikonin and PF-07321332.
Viruses, 16, 2023
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8UTE
 | | Structure of SARS-Cov2 3CLPro in complex with Compound 27 | | 分子名称: | 1,2-ETHANEDIOL, 3C-like proteinase nsp5, methyl {(2S)-1-[(1S,3aR,6aS)-1-{[(2R,3S)-6,6-difluoro-2-hydroxy-1-(methylamino)-1-oxoheptan-3-yl]carbamoyl}hexahydrocyclopenta[c]pyrrol-2(1H)-yl]-3,3-dimethyl-1-oxobutan-2-yl}carbamate | | 著者 | Krishnamurthy, H, Zhuang, N, Qiang, D, Wu, Y, Klein, D.J. | | 登録日 | 2023-10-31 | | 公開日 | 2024-03-06 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Invention of MK-7845, a SARS-CoV-2 3CL Protease Inhibitor Employing a Novel Difluorinated Glutamine Mimic.
J.Med.Chem., 67, 2024
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6A4C
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7CVQ
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7CVO
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7V6Y
 | | Cryo-EM structure of Patched in lipid nanodisc - the wildtype, 3.5 angstrom (re-processed with dataset of 7dzq) | | 分子名称: | (2S)-2-azanyl-3-[[(2S)-3-butanoyloxy-2-dec-9-enoyloxy-propoxy]-oxidanyl-phosphoryl]oxy-propanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Luo, Y, Zhao, Y, Qu, Q, Li, D. | | 登録日 | 2021-08-20 | | 公開日 | 2021-09-22 | | 最終更新日 | 2025-03-19 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Cryo-EM study of patched in lipid nanodisc suggests a structural basis for its clustering in caveolae.
Structure, 29, 2021
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