4EPK
| Evidence for a Dual Role of an Active Site Histidine in alpha-Amino-beta-Carboxymuconate-epsilon-Semialdehyde Decarboxylase | 分子名称: | 2-amino-3-carboxymuconate 6-semialdehyde decarboxylase, MAGNESIUM ION, ZINC ION | 著者 | Huo, L, Fielding, A.J, Chen, Y, Li, T, Iwaki, H, Hosler, J.P, Chen, L, Hasegawa, Y, Que Jr, L, Liu, A. | 登録日 | 2012-04-17 | 公開日 | 2012-08-22 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.6009 Å) | 主引用文献 | Evidence for a Dual Role of an Active Site Histidine in alpha-Amino-beta-Carboxymuconate-epsilon-Semialdehyde Decarboxylase Biochemistry, 51, 2012
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8D4L
| Crystal Structure of SARS-CoV-2 Main Protease (Mpro) S144A Mutant | 分子名称: | 3C-like proteinase nsp5 | 著者 | Lewandowski, E.M, Hu, Y, Tan, H, Wang, J, Chen, Y. | 登録日 | 2022-06-02 | 公開日 | 2022-07-13 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Naturally occurring mutations of SARS-CoV-2 main protease confer drug resistance to nirmatrelvir. Biorxiv, 2022
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8D4K
| Crystal Structure of SARS-CoV-2 Main Protease (Mpro) H172Y Mutant in Complex with Inhibitor GC376 | 分子名称: | (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase nsp5 | 著者 | Lewandowski, E.M, Hu, Y, Tan, H, Wang, J, Chen, Y. | 登録日 | 2022-06-02 | 公開日 | 2022-07-13 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Naturally occurring mutations of SARS-CoV-2 main protease confer drug resistance to nirmatrelvir. Biorxiv, 2022
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8D4M
| Crystal Structure of SARS-CoV-2 Main Protease (Mpro) S144A Mutant in Complex with Inhibitor GC376 | 分子名称: | (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase nsp5 | 著者 | Lewandowski, E.M, Hu, Y, Tan, H, Wang, J, Chen, Y. | 登録日 | 2022-06-02 | 公開日 | 2022-07-13 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | 主引用文献 | Naturally occurring mutations of SARS-CoV-2 main protease confer drug resistance to nirmatrelvir. Biorxiv, 2022
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8D4J
| Crystal Structure of SARS-CoV-2 Main Protease (Mpro) H172Y Mutant | 分子名称: | 3C-like proteinase nsp5, GLYCEROL | 著者 | Lewandowski, E.M, Hu, Y, Tan, H, Wang, J, Chen, Y. | 登録日 | 2022-06-02 | 公開日 | 2022-07-13 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | Naturally occurring mutations of SARS-CoV-2 main protease confer drug resistance to nirmatrelvir. Biorxiv, 2022
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8D4N
| Crystal Structure of SARS-CoV-2 Main Protease (Mpro) E166Q Mutant | 分子名称: | 3C-like proteinase nsp5 | 著者 | Lewandowski, E.M, Hu, Y, Tan, H, Wang, J, Chen, Y. | 登録日 | 2022-06-02 | 公開日 | 2022-07-13 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Naturally occurring mutations of SARS-CoV-2 main protease confer drug resistance to nirmatrelvir. Biorxiv, 2022
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1MVO
| Crystal structure of the PhoP receiver domain from Bacillus subtilis | 分子名称: | MANGANESE (II) ION, PhoP response regulator, SODIUM ION | 著者 | Birck, C, Chen, Y, Hulett, F.M, Samama, J.P, Structural Proteomics in Europe (SPINE) | 登録日 | 2002-09-26 | 公開日 | 2002-10-16 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | The Crystal Structure of the Phosphorylation Domain in PhoP Reveals a Functional Tandem Association Mediated by an Asymmetric Interface J.BACTERIOL., 185, 2003
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1IG6
| HUMAN MRF-2 DOMAIN, NMR, 11 STRUCTURES | 分子名称: | MODULATOR RECOGNITION FACTOR 2 | 著者 | Lin, D, Tsui, V, Case, D, Yuan, Y.C, Chen, Y. | 登録日 | 2001-04-17 | 公開日 | 2001-04-25 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | HUMAN MRF-2 DOMAIN, NMR, 11 STRUCTURES To be Published
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4HMP
| Crystal structure of iron uptake ABC transporter substrate-binding protein PiaA from Streptococcus pneumoniae TIGR4 | 分子名称: | 1,2-ETHANEDIOL, CADMIUM ION, GLYCEROL, ... | 著者 | Cheng, W, Li, Q, Jiang, Y.-L, Chen, Y, Zhou, C.-Z. | 登録日 | 2012-10-18 | 公開日 | 2013-09-04 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structures of Streptococcus pneumoniae PiaA and Its Complex with Ferrichrome Reveal Insights into the Substrate Binding and Release of High Affinity Iron Transporters Plos One, 8, 2013
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4HMO
| Crystal structure of streptococcus pneumoniae TIGR4 PiaA in complex with Bis-tris propane | 分子名称: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, Iron-compound ABC transporter, ... | 著者 | Cheng, W, Li, Q, Jiang, Y.-L, Chen, Y, Zhou, C.-Z. | 登録日 | 2012-10-18 | 公開日 | 2013-09-04 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structures of Streptococcus pneumoniae PiaA and Its Complex with Ferrichrome Reveal Insights into the Substrate Binding and Release of High Affinity Iron Transporters Plos One, 8, 2013
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4HMQ
| Crystal structure of streptococcus pneumoniae TIGR4 PiaA in complex with ferrichrome | 分子名称: | 1,2-ETHANEDIOL, CADMIUM ION, CHLORIDE ION, ... | 著者 | Cheng, W, Li, Q, Jiang, Y.-L, Chen, Y, Zhou, C.-Z. | 登録日 | 2012-10-18 | 公開日 | 2013-09-04 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structures of Streptococcus pneumoniae PiaA and Its Complex with Ferrichrome Reveal Insights into the Substrate Binding and Release of High Affinity Iron Transporters Plos One, 8, 2013
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1C76
| STAPHYLOKINASE (SAK) MONOMER | 分子名称: | STAPHYLOKINASE | 著者 | Rao, Z, Jiang, F, Liu, Y, Zhang, X, Chen, Y, Bartlam, M, Song, H, Ding, Y. | 登録日 | 2000-02-01 | 公開日 | 2000-08-01 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Crystal Structure of Staphylokinase Dimer Offers New Clue to Reduction of Immunogenicity To be published
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6KUA
| Crystal structure of the nicotinamidase SaPncA from Staphylococcus aureus | 分子名称: | Cysteine hydrolase, ZINC ION | 著者 | Shang, F, Lan, J, Liu, W, Xu, Y, Chen, Y. | 登録日 | 2019-08-31 | 公開日 | 2019-10-02 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.104 Å) | 主引用文献 | Crystal structure of the nicotinamidase SaPncA from Staphylococcus aureus To Be Published
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4X3Q
| Crystal structure of S-adenosylmethionine-dependent methyltransferase SibL in complex with SAH | 分子名称: | S-ADENOSYL-L-HOMOCYSTEINE, SibL | 著者 | liu, J.S, Chen, S.C, Yang, C.S, Huang, C.H, Chen, Y. | 登録日 | 2014-12-01 | 公開日 | 2015-11-25 | 実験手法 | X-RAY DIFFRACTION (2.586 Å) | 主引用文献 | Crystal structure of S-adenosylmethionine-dependent methyltransferase SibL in complex with SAH To Be Published, 2015
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6L3E
| Crystal structure of Salmonella enterica sugar-binding protein MalE | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, ... | 著者 | Wang, L, Chen, Y, Liu, W, Lan, J, Shang, F, Xu, Y. | 登録日 | 2019-10-10 | 公開日 | 2019-10-23 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | The crystal structure of Salmonella enterica sugar-binding protein MalE To Be Published
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7PKS
| Structural basis of Integrator-mediated transcription regulation | 分子名称: | DNA Template, DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, ... | 著者 | Fianu, I, Chen, Y, Dienemann, C, Cramer, P. | 登録日 | 2021-08-26 | 公開日 | 2021-12-08 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural basis of Integrator-mediated transcription regulation. Science, 374, 2021
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7XJW
| Crystal structure of canine coronavirus main protease in complex with GC376 | 分子名称: | (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, ORF1a polyprotein | 著者 | Wang, Y.C, Yang, C.S, Hou, M.H, Tsai, C.L, Chiu, Y.F, Chen, Y. | 登録日 | 2022-04-18 | 公開日 | 2023-05-31 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | A Structural Comparison of SARS-CoV-2 Main Protease and Animal Coronaviral Main Protease Reveals Species-Specific Ligand Binding and Dimerization Mechanism. Int J Mol Sci, 23, 2022
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6XA4
| Crystal structure of the SARS-CoV-2 (COVID-19) main protease in complex with UAW241 | 分子名称: | 3C-like proteinase, GLYCEROL, inhibitor UAW241 | 著者 | Sacco, M, Ma, C, Wang, J, Chen, Y. | 登録日 | 2020-06-03 | 公開日 | 2020-06-17 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against M pro and cathepsin L. Sci Adv, 6, 2020
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6XBG
| Crystal structure of the SARS-CoV-2 (COVID-19) main protease in complex with inhibitor UAW246 | 分子名称: | 3C-like proteinase, GLYCEROL, SODIUM ION, ... | 著者 | Sacco, M, Ma, C, Wang, J, Chen, Y. | 登録日 | 2020-06-05 | 公開日 | 2020-06-17 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against M pro and cathepsin L. Sci Adv, 6, 2020
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6XFN
| Crystal structure of the SARS-CoV-2 (COVID-19) main protease in complex with UAW243 | 分子名称: | 3C-like proteinase, GLYCEROL, UAW243 | 著者 | Sacco, M, Ma, C, Wang, J, Chen, Y. | 登録日 | 2020-06-15 | 公開日 | 2020-06-24 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against M pro and cathepsin L. Sci Adv, 6, 2020
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6XBI
| Crystal structure of the SARS-CoV-2 (COVID-19) main protease in complex with inhibitor UAW248 | 分子名称: | 3C-like proteinase, DIMETHYL SULFOXIDE, GLYCEROL, ... | 著者 | Sacco, M, Ma, C, Wang, J, Chen, Y. | 登録日 | 2020-06-06 | 公開日 | 2020-06-17 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against M pro and cathepsin L. Sci Adv, 6, 2020
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6XBH
| Crystal structure of the SARS-CoV-2 (COVID-19) main protease in complex with inhibitor UAW247 | 分子名称: | 3C-like proteinase, GLYCEROL, SODIUM ION, ... | 著者 | Sacco, M, Ma, C, Wang, J, Chen, Y. | 登録日 | 2020-06-06 | 公開日 | 2020-06-17 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against M pro and cathepsin L. Sci Adv, 6, 2020
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5F59
| The crystal structure of MLL3 SET domain | 分子名称: | Histone-lysine N-methyltransferase 2C, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION | 著者 | Li, Y, Lei, M, Chen, Y. | 登録日 | 2015-12-04 | 公開日 | 2016-02-24 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.801 Å) | 主引用文献 | Structural basis for activity regulation of MLL family methyltransferases. Nature, 530, 2016
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5F5E
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5F6L
| The crystal structure of MLL1 (N3861I/Q3867L) in complex with RbBP5 and Ash2L | 分子名称: | Histone-lysine N-methyltransferase 2A, Retinoblastoma-binding protein 5, S-ADENOSYL-L-HOMOCYSTEINE, ... | 著者 | Li, Y, Lei, M, Chen, Y. | 登録日 | 2015-12-06 | 公開日 | 2016-02-24 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural basis for activity regulation of MLL family methyltransferases. Nature, 530, 2016
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