7XJW

Crystal structure of canine coronavirus main protease in complex with GC376

Summary for 7XJW

• Entry DOI: 10.2210/pdb7xjw/pdb
• Descriptor: ORF1a polyprotein, (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid (3 entities in total)
• Functional Keywords: 3c-like proteinase, viral protein-inhibitor complex, viral protein/inhibitor
• Biological source: Canine coronavirus
• Total number of polymer chains: 8
• Total formula weight: 268471.82

Authors

Wang, Y.C.,Yang, C.S.,Hou, M.H.,Tsai, C.L.,Chiu, Y.F.,Chen, Y. (deposition date: 2022-04-18, release date: 2023-05-31, Last modification date: 2023-11-29)

• Primary citation: Ho, C.Y.,Yu, J.X.,Wang, Y.C.,Lin, Y.C.,Chiu, Y.F.,Gao, J.Y.,Lai, S.J.,Chen, M.J.,Huang, W.C.,Tien, N.,Chen, Y.; A Structural Comparison of SARS-CoV-2 Main Protease and Animal Coronaviral Main Protease Reveals Species-Specific Ligand Binding and Dimerization Mechanism.; Int J Mol Sci, 23:-, 2022; PubMed: 35628479; DOI: 10.3390/ijms23105669

Experimental method

X-RAY DIFFRACTION (2.75 Å)