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Cryo-EM structure of an activated Cholecystokinin A receptor (CCKAR)-Gs complex
分子名称:	Chimera of Guanine nucleotide-binding protein G(i) subunit alpha-1 and Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Cholecystokinin receptor type A, Cholecystokinin-8, ...
著者	Liu, Q.F, Yang, D.H, Zhuang, Y.W, Croll, T.I, Cai, X.Q, Duan, J, Dai, A.T, Yin, W.C, Ye, C.Y, Zhou, F.L, Wu, B.L, Zhao, Q, Xu, H.E, Wang, M.W, Jiang, Y.
登録日	2021-06-01
公開日	2021-08-25
最終更新日	2024-11-06
実験手法	ELECTRON MICROSCOPY (3.1 Å)
主引用文献	Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor Nat.Chem.Biol., 17, 2021

5WPV

Cryo-EM structure of mammalian endolysosomal TRPML1 channel in nanodiscs at 3.59 Angstrom resolution
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Mucolipin-1, SODIUM ION
著者	Chen, Q, She, J, Guo, J, Bai, X, Jiang, Y.
登録日	2017-08-07
公開日	2017-10-18
最終更新日	2024-11-13
実験手法	ELECTRON MICROSCOPY (3.59 Å)
主引用文献	Structure of mammalian endolysosomal TRPML1 channel in nanodiscs. Nature, 550, 2017

7W19

Crystal Structure of Acinetobacter baumannii MPH-E
分子名称:	CALCIUM ION, MAGNESIUM ION, Macrolide 2'-phosphotransferase
著者	Qi, Q, Kuang, L, Jiang, Y.
登録日	2021-11-19
公開日	2022-12-07
最終更新日	2023-11-29
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Crystal Structure of the Acinetobacter baumannii Macrolide Phosphotransferases E Reveal the Novel Catalysis Mechanism To Be Published

7YJE

Crystal structure of the P450 BM3 heme domain mutant F87G/T268V/A184V/A328V in complex with N-imidazolyl-hexanoyl-L-phenylalanine and acetate ion
分子名称:	(2S)-2-(6-imidazol-1-ylhexanoylamino)-3-phenyl-propanoic acid, ACETATE ION, Bifunctional cytochrome P450/NADPH--P450 reductase, ...
著者	Dong, S, Chen, J, Jiang, Y, Cong, Z, Feng, Y.
登録日	2022-07-20
公開日	2023-05-24
最終更新日	2023-11-29
実験手法	X-RAY DIFFRACTION (1.85 Å)
主引用文献	Regiodivergent and Enantioselective Hydroxylation of C-H bonds by Synergistic Use of Protein Engineering and Exogenous Dual-Functional Small Molecules. Angew.Chem.Int.Ed.Engl., 62, 2023

7YJG

Crystal structure of the P450 BM3 heme domain mutant F87A/T268V/A82C/L181M in complex with N-imidazolyl-pentanoyl-L-phenylalanine and hydroxylamine
分子名称:	(2~{S})-2-(5-imidazol-1-ylpentanoylamino)-3-phenyl-propanoic acid, Bifunctional cytochrome P450/NADPH--P450 reductase, HYDROXYAMINE, ...
著者	Dong, S, Chen, J, Jiang, Y, Cong, Z, Feng, Y.
登録日	2022-07-20
公開日	2023-05-24
最終更新日	2023-11-29
実験手法	X-RAY DIFFRACTION (1.684 Å)
主引用文献	Regiodivergent and Enantioselective Hydroxylation of C-H bonds by Synergistic Use of Protein Engineering and Exogenous Dual-Functional Small Molecules. Angew.Chem.Int.Ed.Engl., 62, 2023

7YJH

Crystal structure of the P450 BM3 heme domain mutant F87V/T268I in complex with N-imidazolyl-pentanoyl-L-phenylalanine and hydroxylamine
分子名称:	(2~{S})-2-(5-imidazol-1-ylpentanoylamino)-3-phenyl-propanoic acid, Bifunctional cytochrome P450/NADPH--P450 reductase, HYDROXYAMINE, ...
著者	Dong, S, Chen, J, Jiang, Y, Cong, Z, Feng, Y.
登録日	2022-07-20
公開日	2023-05-24
最終更新日	2023-11-29
実験手法	X-RAY DIFFRACTION (1.792 Å)
主引用文献	Regiodivergent and Enantioselective Hydroxylation of C-H bonds by Synergistic Use of Protein Engineering and Exogenous Dual-Functional Small Molecules. Angew.Chem.Int.Ed.Engl., 62, 2023

7YJF

Crystal structure of the P450 BM3 heme domain mutant F87A/T268P/V78I in complex with N-imidazolyl-pentanoyl-L-phenylalanine and hydroxylamine
分子名称:	(2~{S})-2-(5-imidazol-1-ylpentanoylamino)-3-phenyl-propanoic acid, HYDROXYAMINE, P450 BM3 heme domain mutant F87A/T268P/V78I, ...
著者	Dong, S, Chen, J, Jiang, Y, Cong, Z, Feng, Y.
登録日	2022-07-20
公開日	2023-05-24
最終更新日	2023-11-29
実験手法	X-RAY DIFFRACTION (1.515 Å)
主引用文献	Regiodivergent and Enantioselective Hydroxylation of C-H bonds by Synergistic Use of Protein Engineering and Exogenous Dual-Functional Small Molecules. Angew.Chem.Int.Ed.Engl., 62, 2023

7F2O

Cryo-EM structure of the type 2 bradykinin receptor in complex with the bradykinin and an Gq protein
分子名称:	ARG-PRO-PRO-GLY-PHE-SER-PRO-PHE-ARG, B2 bradykinin receptor, G subunit q (Gi1-Gq chimeric), ...
著者	Yin, Y, Jiang, Y.
登録日	2021-06-11
公開日	2021-10-13
最終更新日	2024-10-16
実験手法	ELECTRON MICROSCOPY (2.9 Å)
主引用文献	Molecular basis for kinin selectivity and activation of the human bradykinin receptors. Nat.Struct.Mol.Biol., 28, 2021

5VRE

Crystal structure of a lysosomal potassium-selective channel TMEM175 homolog from Chamaesiphon Minutus
分子名称:	Putative integral membrane protein
著者	Lee, C, Guo, J, Jiang, Y.
登録日	2017-05-10
公開日	2017-07-19
最終更新日	2024-03-13
実験手法	X-RAY DIFFRACTION (3.299 Å)
主引用文献	The lysosomal potassium channel TMEM175 adopts a novel tetrameric architecture. Nature, 547, 2017

7WBJ

Cryo-EM structure of N-terminal modified human vasoactive intestinal polypeptide receptor 2 (VIP2R) in complex with PACAP27 and Gs
分子名称:	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
著者	Xu, Y.N, Feng, W.B, Zhou, Q.T, Liang, A.Y, Li, J, Dai, A.T, Zhao, F.H, Yan, J.H, Chen, C.W, Li, H, Zhao, L.H, Xia, T, Jiang, Y, Xu, H.E, Yang, D.H, Wang, M.W.
登録日	2021-12-16
公開日	2022-05-18
最終更新日	2024-11-13
実験手法	ELECTRON MICROSCOPY (3.42 Å)
主引用文献	A distinctive ligand recognition mechanism by the human vasoactive intestinal polypeptide receptor 2. Nat Commun, 13, 2022

7W56

Cryo-EM structure of the neuromedin S-bound neuromedin U receptor 1-Gq protein complex
分子名称:	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha, ...
著者	You, C, Xu, H.E, Jiang, Y.
登録日	2021-11-29
公開日	2022-04-20
最終更新日	2024-10-23
実験手法	ELECTRON MICROSCOPY (2.9 Å)
主引用文献	Structural insights into the peptide selectivity and activation of human neuromedin U receptors. Nat Commun, 13, 2022

7W57

Cryo-EM structure of the neuromedin S-bound neuromedin U receptor 2-Gq protein complex
分子名称:	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha, ...
著者	You, C, Xu, H.E, Jiang, Y.
登録日	2021-11-29
公開日	2022-04-20
最終更新日	2024-11-13
実験手法	ELECTRON MICROSCOPY (3.2 Å)
主引用文献	Structural insights into the peptide selectivity and activation of human neuromedin U receptors. Nat Commun, 13, 2022

7W55

Cryo-EM structure of the neuromedin U-bound neuromedin U receptor 2-Gq protein complex
分子名称:	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha, ...
著者	You, C, Xu, H.E, Jiang, Y.
登録日	2021-11-29
公開日	2022-04-20
最終更新日	2022-06-15
実験手法	ELECTRON MICROSCOPY (2.8 Å)
主引用文献	Structural insights into the peptide selectivity and activation of human neuromedin U receptors. Nat Commun, 13, 2022

7W53

Cryo-EM structure of the neuromedin U-bound neuromedin U receptor 1-Gq protein complex
分子名称:	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha, ...
著者	You, C, Xu, H.E, Jiang, Y.
登録日	2021-11-29
公開日	2022-04-20
最終更新日	2024-11-13
実験手法	ELECTRON MICROSCOPY (3.2 Å)
主引用文献	Structural insights into the peptide selectivity and activation of human neuromedin U receptors. Nat Commun, 13, 2022

7DW9

Cryo-EM structure of human V2 vasopressin receptor in complex with an Gs protein
分子名称:	CHOLESTEROL, CYS-TYR-PHE-GLN-ASN-CYS-PRO-ARG-GLY-NH2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者	Zhou, F, Jiang, Y.
登録日	2021-01-15
公開日	2021-07-21
最終更新日	2024-10-23
実験手法	ELECTRON MICROSCOPY (2.6 Å)
主引用文献	Molecular basis of ligand recognition and activation of human V2 vasopressin receptor. Cell Res., 31, 2021

7FHO

Structure of AtTPC1 D240A/D454A/E528A mutant with 50 mM Ca2+
分子名称:	CALCIUM ION, Two pore calcium channel protein 1,GFP
著者	Ye, F, Xu, L, Li, X, Jiang, Y, Guo, J.
登録日	2021-07-29
公開日	2021-12-01
最終更新日	2024-11-13
実験手法	ELECTRON MICROSCOPY (2.8 Å)
主引用文献	Voltage-gating and cytosolic Ca 2+ activation mechanisms of Arabidopsis two-pore channel AtTPC1. Proc.Natl.Acad.Sci.USA, 118, 2021

7FHN

Structure of AtTPC1 D240A/D454A/E528A mutant with 1 mM Ca2+
分子名称:	CALCIUM ION, Two pore calcium channel protein 1,GFP
著者	Ye, F, Xu, L, Li, X, Jiang, Y, Guo, J.
登録日	2021-07-29
公開日	2021-12-01
最終更新日	2024-10-16
実験手法	ELECTRON MICROSCOPY (3.3 Å)
主引用文献	Voltage-gating and cytosolic Ca 2+ activation mechanisms of Arabidopsis two-pore channel AtTPC1. Proc.Natl.Acad.Sci.USA, 118, 2021

7FHL

Structure of AtTPC1 with 50 mM Ca2+
分子名称:	AtTPC1-Cter, CALCIUM ION, Two pore calcium channel protein 1,GFP
著者	Ye, F, Xu, L, Li, X, Jiang, Y, Guo, J.
登録日	2021-07-29
公開日	2021-12-01
最終更新日	2024-10-30
実験手法	ELECTRON MICROSCOPY (3.1 Å)
主引用文献	Voltage-gating and cytosolic Ca 2+ activation mechanisms of Arabidopsis two-pore channel AtTPC1. Proc.Natl.Acad.Sci.USA, 118, 2021

7FHK

Structure of AtTPC1 with 1 mM Ca2+
分子名称:	AtTPC1-Cter, CALCIUM ION, Two pore calcium channel protein 1,GFP
著者	Ye, F, Xu, L, Li, X, Jiang, Y, Guo, J.
登録日	2021-07-29
公開日	2021-12-01
最終更新日	2024-06-12
実験手法	ELECTRON MICROSCOPY (3.3 Å)
主引用文献	Voltage-gating and cytosolic Ca 2+ activation mechanisms of Arabidopsis two-pore channel AtTPC1. Proc.Natl.Acad.Sci.USA, 118, 2021

4KTC

NS3/NS4A protease with inhibitor
分子名称:	(2R,6S,13aR,14aR,16aS)-6-{[(cyclopentyloxy)carbonyl]amino}-14a-[(cyclopropylsulfonyl)carbamoyl]-5,16-dioxooctadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl 3,4-dihydroisoquinoline-2(1H)-carboxylate, NS4A peptide, Serine protease NS3, ...
著者	Zhang, H, Ballard, J, Vigers, G.P.A, Brandhuber, B.J.
登録日	2013-05-20
公開日	2013-08-07
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Discovery of Danoprevir (ITMN-191/R7227), a Highly Selective and Potent Inhibitor of Hepatitis C Virus (HCV) NS3/4A Protease. J.Med.Chem., 57, 2014

5ZQ8

Crystal structure of spRlmCD with U747 stemloop RNA
分子名称:	NICKEL (II) ION, RNA (5'-R(CPCPGPUP(MUM)PGPAPAPAPAPGPG)-3'), S-ADENOSYL-L-HOMOCYSTEINE, ...
著者	Jiang, Y.Y, Yu, H.L.
登録日	2018-04-17
公開日	2018-10-24
最終更新日	2024-11-13
実験手法	X-RAY DIFFRACTION (2.18 Å)
主引用文献	Unveiling the structural features that determine the dual methyltransferase activities of Streptococcus pneumoniae RlmCD PLoS Pathog., 14, 2018

5ZTH

Crystal structure of spRlmCD with U1939loop RNA at 3.24 angstrom
分子名称:	RNA (5'-R(PAPAPAP(MUM)PUPCPCPU)-3'), S-ADENOSYL-L-HOMOCYSTEINE, Uncharacterized RNA methyltransferase SP_1029
著者	Jiang, Y.Y, Yu, H.L.
登録日	2018-05-03
公開日	2018-10-24
最終更新日	2024-10-23
実験手法	X-RAY DIFFRACTION (3.24 Å)
主引用文献	Unveiling the structural features that determine the dual methyltransferase activities of Streptococcus pneumoniae RlmCD PLoS Pathog., 14, 2018

5ZQ1

Crystal structure of spRlmCD with U1939loop RNA at 3.10 angstrom
分子名称:	RNA (5'-R(APAPAP(MUM)PUPCPCPU)-3'), S-ADENOSYL-L-HOMOCYSTEINE, Uncharacterized RNA methyltransferase SP_1029
著者	Yu, H.L, Jiang, Y.Y.
登録日	2018-04-17
公開日	2018-10-24
最終更新日	2024-11-06
実験手法	X-RAY DIFFRACTION (3.1 Å)
主引用文献	Unveiling the structural features that determine the dual methyltransferase activities of Streptococcus pneumoniae RlmCD PLoS Pathog., 14, 2018

5ZQ0

Crystal structure of spRlmCD with U747loop RNA
分子名称:	RNA (5'-R(GPUP(MUM)PGPAPAPAPA)-3'), S-ADENOSYL-L-HOMOCYSTEINE, Uncharacterized RNA methyltransferase SP_1029
著者	Jiang, Y.Y, Yu, H.L.
登録日	2018-04-17
公開日	2018-10-24
最終更新日	2023-11-22
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Unveiling the structural features that determine the dual methyltransferase activities of Streptococcus pneumoniae RlmCD PLoS Pathog., 14, 2018

6L5Z

Crystal strucutre of AF9 YEATS domain in complex with a cyclopeptide inhibitor
分子名称:	Protein AF-9, SC0-ALO-ALA-SC3-SC4-NH2
著者	Li, Y, Chen, G, Li, H.
登録日	2019-10-25
公開日	2020-10-28
最終更新日	2023-11-22
実験手法	X-RAY DIFFRACTION (3.05 Å)
主引用文献	Selective Targeting of AF9 YEATS Domain by Cyclopeptide Inhibitors with Preorganized Conformation. J.Am.Chem.Soc., 142, 2020

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全ヒット件数:	654
表示件数:	25
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