7Z93
| Crystal structure of YTHDF2 with compound YLI_DF_022 | 分子名称: | 5-azanyl-6-ethyl-1H-pyrimidine-2,4-dione, CHLORIDE ION, SULFATE ION, ... | 著者 | Nai, F, Li, Y, Caflisch, A. | 登録日 | 2022-03-19 | 公開日 | 2022-03-30 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Fragment Ligands of the m 6 A-RNA Reader YTHDF2. Acs Med.Chem.Lett., 13, 2022
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7Z8X
| Crystal structure of YTHDF2 with compound YLI_DC1_017 | 分子名称: | 6-methoxy-1H-pyrimidine-2,4-dione, SULFATE ION, YTH domain-containing family protein 2 | 著者 | Nachawati, R, Nai, F, Li, Y, Caflisch, A. | 登録日 | 2022-03-18 | 公開日 | 2022-04-06 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Fragment Ligands of the m 6 A-RNA Reader YTHDF2. Acs Med.Chem.Lett., 13, 2022
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7ZG4
| Crystal structure of YTHDF2 with compound YLI_DF_042 | 分子名称: | GLYCEROL, N-methylpyrimidine-2-carboximidamide, SULFATE ION, ... | 著者 | Nai, F, Li, Y, Caflisch, A. | 登録日 | 2022-04-01 | 公開日 | 2022-04-20 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Fragment Ligands of the m 6 A-RNA Reader YTHDF2. Acs Med.Chem.Lett., 13, 2022
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7Z54
| Crystal structure of YTHDF2 with compound YLI_DC1_006 | 分子名称: | 9-cyclopropyl-~{N}-methyl-purin-6-amine, CHLORIDE ION, GLYCEROL, ... | 著者 | Nai, F, Li, Y, Dolbois, A, Caflisch, A. | 登録日 | 2022-03-07 | 公開日 | 2022-06-22 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | Fragment Ligands of the m 6 A-RNA Reader YTHDF2. Acs Med.Chem.Lett., 13, 2022
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7Z5M
| Crystal structure of YTHDF2 with compound YLI_DC1_008 | 分子名称: | CHLORIDE ION, GLYCEROL, SULFATE ION, ... | 著者 | Nai, F, Li, Y, Caflisch, A. | 登録日 | 2022-03-09 | 公開日 | 2022-06-22 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Fragment Ligands of the m 6 A-RNA Reader YTHDF2. Acs Med.Chem.Lett., 13, 2022
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7Z7B
| Crystal structure of YTHDF2 with compound YLI_DC1_003 | 分子名称: | CHLORIDE ION, GLYCEROL, SULFATE ION, ... | 著者 | Nai, F, Li, Y, Dolbois, A, Caflisch, A. | 登録日 | 2022-03-15 | 公開日 | 2022-06-22 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Fragment Ligands of the m 6 A-RNA Reader YTHDF2. Acs Med.Chem.Lett., 13, 2022
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8WA3
| Cryo-EM structure of peptide free and Gs-coupled GIPR | 分子名称: | Gastric inhibitory polypeptide receptor,Fusion protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1,O-antigen polymerase, ... | 著者 | Cong, Z.T, Zhao, F.H, Li, Y, Luo, G, Zhou, Q.T, Yang, D.H, Wang, M.W. | 登録日 | 2023-09-06 | 公開日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (2.86 Å) | 主引用文献 | Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with G s proteins. Cell Discov, 10, 2024
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8WG7
| Cryo-EM structures of peptide free and Gs-coupled GLP-1R | 分子名称: | Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Cong, Z.T, Zhao, F.H, Li, Y, Luo, G, Zhou, Q.T, Yang, D.H, Wang, M.W. | 登録日 | 2023-09-20 | 公開日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (2.54 Å) | 主引用文献 | Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with G s proteins. Cell Discov, 10, 2024
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8WG8
| Cryo-EM structures of peptide free and Gs-coupled GCGR | 分子名称: | Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Cong, Z.T, Zhao, F.H, Li, Y, Luo, G, Zhou, Q.T, Yang, D.H, Wang, M.W. | 登録日 | 2023-09-20 | 公開日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (2.71 Å) | 主引用文献 | Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with G s proteins. Cell Discov, 10, 2024
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5X29
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5XI4
| BRD4 bound with compound Bdi4 | 分子名称: | (3~{S})-4-cyclopropyl-1,3-dimethyl-6-[[(1~{S})-1-(4-methylphenyl)ethyl]amino]-3~{H}-quinoxalin-2-one, Bromodomain-containing protein 4 | 著者 | Xiong, B, Cao, D, Li, Y. | 登録日 | 2017-04-25 | 公開日 | 2018-05-02 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.486 Å) | 主引用文献 | BRD4 bound with compound Bdi4 To Be Published
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5XI3
| BRD4 bound with compound Bdi3 | 分子名称: | (3~{R})-4-cyclopropyl-1,3-dimethyl-6-[[(1~{R})-1-phenylethyl]amino]-3~{H}-quinoxalin-2-one, Bromodomain-containing protein 4 | 著者 | Xiong, B, Cao, D, Li, Y. | 登録日 | 2017-04-25 | 公開日 | 2018-05-02 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.674 Å) | 主引用文献 | BRD4 bound with compound Bdi3 To Be Published
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7T39
| Co-crystal structure of human PRMT9 in complex with MT221 inhibitor | 分子名称: | 7-[5-S-(4-{[(2-ethylpyridin-3-yl)methyl]amino}butyl)-5-thio-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Protein arginine N-methyltransferase 9 | 著者 | Zeng, H, Dong, A, Hutchinson, A, Seitova, A, Li, Y, Gao, Y.D, Schneider, S, Siliphaivanh, P, Sloman, D, Nicholson, B, Fischer, C, Hicks, J, Brown, P.J, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | 登録日 | 2021-12-07 | 公開日 | 2021-12-22 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | 主引用文献 | Co-crystal structure of human PRMT9 in complex with MT221 inhibitor To Be Published
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8Y6P
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8Z1E
| A homotrimeric GPCR architecture of the human cytomegalovirus (UL78) revealed by cryo-EM | 分子名称: | Uncharacterized protein UL78 | 著者 | Chen, Y, Li, Y, Zhou, Q, Cong, Z, Lin, S, Yan, J, Chen, X, Yang, D, Ying, T, Wang, M.-W. | 登録日 | 2024-04-11 | 公開日 | 2024-05-15 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.12 Å) | 主引用文献 | A homotrimeric GPCR architecture of the human cytomegalovirus revealed by cryo-EM. Cell Discov, 10, 2024
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8VIS
| Human TMPRSS11D complexed with a disulfide-linked autoinhibitory DDDDK peptide | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, MAGNESIUM ION, ... | 著者 | Fraser, B.J, Dong, A, Ilyassov, O, Kenney, T, Li, Y.Y, Seitova, A, Li, Y, Hejazi, Z, Edwards, A, Benard, F, Arrowsmith, C. | 登録日 | 2024-01-05 | 公開日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | 主引用文献 | Human TMPRSS11D complexed with a disulfide-linked autoinhibitory DDDDK peptide To Be Published
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4RXX
| Crystal Structure of the N-terminal Domain of Human Ubiquitin Specific Protease 38 | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, UNKNOWN ATOM OR ION, ... | 著者 | Dong, A, Shen, L, Hu, J, Li, Y, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Tong, Y, Structural Genomics Consortium (SGC) | 登録日 | 2014-12-12 | 公開日 | 2015-01-21 | 最終更新日 | 2017-11-22 | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | 主引用文献 | Crystal Structure of the N-terminal Domain of Human Ubiquitin Specific Protease 38 to be published
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4TVR
| Tandem Tudor and PHD domains of UHRF2 | 分子名称: | E3 ubiquitin-protein ligase UHRF2, UNKNOWN ATOM OR ION, ZINC ION | 著者 | Walker, J.R, Dong, A, Zhang, Q, Ong, M, Duan, S, Li, Y, Bountra, C, Weigelt, J, Edwards, A.M, Arrowsmith, C.H, Tong, Y, Structural Genomics Consortium (SGC) | 登録日 | 2014-06-27 | 公開日 | 2015-06-24 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | 主引用文献 | Structure of the Tandem Tudor and PHD domains of UHRF2 To be published
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7V1N
| Structure of the Clade 2 C. difficile TcdB in complex with its receptor TFPI | 分子名称: | Isoform Beta of Tissue factor pathway inhibitor, Toxin B | 著者 | Luo, J, Yang, Q, Zhang, X, Zhang, Y, Wan, L, Li, Y, Tao, L. | 登録日 | 2021-08-05 | 公開日 | 2022-02-23 | 最終更新日 | 2022-03-30 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | TFPI is a colonic crypt receptor for TcdB from hypervirulent clade 2 C. difficile. Cell, 185, 2022
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5JWH
| Apo structure | 分子名称: | 1,2-ETHANEDIOL, NS3 helicase | 著者 | Cao, X, Li, Y, Jin, T. | 登録日 | 2016-05-12 | 公開日 | 2016-11-09 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Molecular mechanism of divalent-metal-induced activation of NS3 helicase and insights into Zika virus inhibitor design. Nucleic Acids Res., 44, 2016
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5K8L
| Crystal structure of ZIKV NS3 helicase in complex with GTP-gammar S | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ... | 著者 | Cao, X, Li, Y, Jin, T. | 登録日 | 2016-05-30 | 公開日 | 2016-11-09 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.751 Å) | 主引用文献 | Molecular mechanism of divalent-metal-induced activation of NS3 helicase and insights into Zika virus inhibitor design. Nucleic Acids Res., 44, 2016
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5K8U
| Crystal structure of ZIKV NS3 helicase in complex with ADP and Mn2+ | 分子名称: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ... | 著者 | Cao, X, Li, Y, Jin, T. | 登録日 | 2016-05-31 | 公開日 | 2016-11-09 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.601 Å) | 主引用文献 | Molecular mechanism of divalent-metal-induced activation of NS3 helicase and insights into Zika virus inhibitor design. Nucleic Acids Res., 44, 2016
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5K8I
| Crystal structure of ZIKV NS3 helicase in complex with ATP and Mn2+ | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, MANGANESE (II) ION, ... | 著者 | Cao, X, Li, Y, Jin, T. | 登録日 | 2016-05-30 | 公開日 | 2016-11-09 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.694 Å) | 主引用文献 | Molecular mechanism of divalent-metal-induced activation of NS3 helicase and insights into Zika virus inhibitor design. Nucleic Acids Res., 44, 2016
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5K8T
| Crystal structure of ZIKV NS3 helicase in complex with GTP-gammar S and an magnesium ion | 分子名称: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Cao, X, Li, Y, Jin, T. | 登録日 | 2016-05-31 | 公開日 | 2016-11-09 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.848 Å) | 主引用文献 | Molecular mechanism of divalent-metal-induced activation of NS3 helicase and insights into Zika virus inhibitor design. Nucleic Acids Res., 44, 2016
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5MSZ
| Lytic Polysaccharide Monooxygenase AA15 from Thermobia domestica in the Cu(I) State | 分子名称: | 1,2-ETHANEDIOL, COPPER (I) ION, Thermobia domestica domestica AA15 | 著者 | Hemsworth, G.R, Sabbadin, F, Ciano, L, Henrissat, B, Dupree, P, Tryfona, T, Besser, K, Elias, L, Pesante, G, Li, Y, Dowle, A, Bates, R, Gomez, L, Hallam, R, Davies, G.J, Walton, P.H, Bruce, N.C, McQueen-Mason, S. | 登録日 | 2017-01-06 | 公開日 | 2018-02-28 | 最終更新日 | 2018-03-07 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | An ancient family of lytic polysaccharide monooxygenases with roles in arthropod development and biomass digestion. Nat Commun, 9, 2018
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