2BFF
 
 | | Reactivity modulation of human branched-chain alpha-ketoacid dehydrogenase by an internal molecular switch | | 分子名称: | 2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT, 2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT, 2-{3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-4-METHYL-2-OXO-2,3-DIHYDRO-1,3-THIAZOL-5-YL}ETHYL TRIHYDROGEN DIPHOSPHATE, ... | | 著者 | Machius, M, Wynn, R.M, Chuang, J.L, Tomchick, D.R, Brautigam, C.A, Chuang, D.T. | | 登録日 | 2004-12-06 | | 公開日 | 2006-02-16 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | | 主引用文献 | A Versatile Conformational Switch Regulates Reactivity in Human Branched-Chain Alpha-Ketoacid Dehydrogenase.
Structure, 14, 2006
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1T0W
 | | 25 NMR structures of Truncated Hevein of 32 aa (Hevein-32) complex with N,N,N-triacetylglucosamina | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hevein | | 著者 | Aboitiz, N, Vila-Perello, M, Groves, P, Asensio, J.L, Andreu, D, Canada, F.J, Jimenez-Barbero, J. | | 登録日 | 2004-04-13 | | 公開日 | 2004-09-28 | | 最終更新日 | 2020-07-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | NMR and modeling studies of protein-carbohydrate interactions: synthesis, three-dimensional structure, and recognition properties of a minimum hevein domain with binding affinity for chitooligosaccharides
Chembiochem, 5, 2004
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1T9O
 | | Crystal Structure of V44G Cp Rubredoxin | | 分子名称: | FE (III) ION, Rubredoxin | | 著者 | Park, I.Y, Eidsness, M.K, Lin, I.J, Gebel, E.B, Youn, B, Harley, J.L, Machonkin, T.E, Frederick, R.O, Markley, J.L, Smith, E.T, Ichiye, T, Kang, C. | | 登録日 | 2004-05-18 | | 公開日 | 2004-10-05 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystallographic studies of V44 mutants of Clostridium pasteurianum rubredoxin: Effects of side-chain size on reduction potential.
Proteins, 57, 2004
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3OSL
 | | Structure of bovine thrombin-activatable fibrinolysis inhibitor in complex with tick carboxypeptidase inhibitor | | 分子名称: | Carboxypeptidase B2, Carboxypeptidase inhibitor, ZINC ION | | 著者 | Valnickova, Z, Sanglas, L, Arolas, J.L, Petersen, S.V, Schar, C, Otzen, D, Aviles, F.X, Gomis-Ruth, F.X, Enghild, J.J. | | 登録日 | 2010-09-09 | | 公開日 | 2010-09-29 | | 最終更新日 | 2017-11-08 | | 実験手法 | X-RAY DIFFRACTION (6 Å) | | 主引用文献 | Flexibility of the Thrombin-activatable Fibrinolysis Inhibitor Pro-domain Enables Productive Binding of Protein Substrates.
J.Biol.Chem., 285, 2010
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1T9P
 | | Crystal Structure of V44A, G45P Cp Rubredoxin | | 分子名称: | FE (III) ION, Rubredoxin | | 著者 | Park, I.Y, Eidsness, M.K, Lin, I.J, Gebel, E.B, Youn, B, Harley, J.L, Machonkin, T.E, Frederick, R.O, Markley, J.L, Smith, E.T, Ichiye, T, Kang, C. | | 登録日 | 2004-05-18 | | 公開日 | 2004-10-05 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Crystallographic studies of V44 mutants of Clostridium pasteurianum rubredoxin: Effects of side-chain size on reduction potential.
Proteins, 57, 2004
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1T9Q
 | | Crystal Structure of V44L Cp Rubredoxin | | 分子名称: | FE (III) ION, Rubredoxin | | 著者 | Park, I.Y, Eidsness, M.K, Lin, I.J, Gebel, E.B, Youn, B, Harley, J.L, Machonkin, T.E, Frederick, R.O, Markley, J.L, Smith, E.T, Ichiye, T, Kang, C. | | 登録日 | 2004-05-18 | | 公開日 | 2004-10-05 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystallographic studies of V44 mutants of Clostridium pasteurianum rubredoxin: Effects of side-chain size on reduction potential.
Proteins, 57, 2004
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7UZJ
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7UZH
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7UZI
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7UZF
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7UZK
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7WXG
 | | GPR domain closed form of Drosophila P5CS filament with glutamate, ATP, and NADPH | | 分子名称: | Delta-1-pyrroline-5-carboxylate synthase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Liu, J.L, Zhong, J, Guo, C.J, Zhou, X. | | 登録日 | 2022-02-14 | | 公開日 | 2022-03-30 | | 最終更新日 | 2022-04-06 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Structural basis of dynamic P5CS filaments.
Elife, 11, 2022
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7WXF
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7WXI
 | | GPR domain of Drosophila P5CS filament with glutamate and ATPgammaS | | 分子名称: | Delta-1-pyrroline-5-carboxylate synthase, GAMMA-GLUTAMYL PHOSPHATE | | 著者 | Liu, J.L, Zhong, J, Guo, C.J, Zhou, X. | | 登録日 | 2022-02-14 | | 公開日 | 2022-03-30 | | 最終更新日 | 2022-04-06 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Structural basis of dynamic P5CS filaments.
Elife, 11, 2022
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7WXH
 | | GPR domain open form of Drosophila P5CS filament with glutamate, ATP, and NADPH | | 分子名称: | Delta-1-pyrroline-5-carboxylate synthase | | 著者 | Liu, J.L, Zhong, J, Guo, C.J, Zhou, X. | | 登録日 | 2022-02-14 | | 公開日 | 2022-03-30 | | 最終更新日 | 2022-04-06 | | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | | 主引用文献 | Structural basis of dynamic P5CS filaments.
Elife, 11, 2022
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7WX4
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7WX3
 | | GK domain of Drosophila P5CS filament with glutamate, ATP, and NADPH | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Delta-1-pyrroline-5-carboxylate synthase, GAMMA-GLUTAMYL PHOSPHATE, ... | | 著者 | Liu, J.L, Zhong, J, Guo, C.J, Zhou, X. | | 登録日 | 2022-02-14 | | 公開日 | 2022-04-06 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural basis of dynamic P5CS filaments.
Elife, 11, 2022
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7XMU
 | | E.coli phosphoribosylpyrophosphate (PRPP) synthetase type A filament bound with ADP, Pi and R5P | | 分子名称: | 5-O-phosphono-alpha-D-ribofuranose, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Hu, H.H, Lu, G.M, Chang, C.C, Liu, J.L. | | 登録日 | 2022-04-26 | | 公開日 | 2022-06-29 | | 最終更新日 | 2022-07-06 | | 実験手法 | ELECTRON MICROSCOPY (2.3 Å) | | 主引用文献 | Filamentation modulates allosteric regulation of PRPS.
Elife, 11, 2022
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7XN3
 | | E.coli phosphoribosylpyrophosphate (PRPP) synthetase type B filament bound with Pi | | 分子名称: | PHOSPHATE ION, Ribose-phosphate pyrophosphokinase | | 著者 | Hu, H.H, Lu, G.M, Chang, C.C, Liu, J.L. | | 登録日 | 2022-04-27 | | 公開日 | 2022-06-29 | | 最終更新日 | 2022-07-06 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Filamentation modulates allosteric regulation of PRPS.
Elife, 11, 2022
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7XMV
 | | E.coli phosphoribosylpyrophosphate (PRPP) synthetase type A(AMP/ADP) filament bound with ADP, AMP and R5P | | 分子名称: | 5-O-phosphono-alpha-D-ribofuranose, ADENOSINE MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, ... | | 著者 | Hu, H.H, Lu, G.M, Chang, C.C, Liu, J.L. | | 登録日 | 2022-04-27 | | 公開日 | 2022-06-29 | | 最終更新日 | 2022-07-06 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Filamentation modulates allosteric regulation of PRPS.
Elife, 11, 2022
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7UK8
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7UBT
 | | Stat5a Core in complex with Compound 18 | | 分子名称: | GLYCEROL, N-{5-[difluoro(phosphono)methyl]-1-benzothiophene-2-carbonyl}-3-methyl-L-valyl-L-prolyl-N~3~-(1,3-benzothiazol-5-yl)-N,N-dimethyl-beta-alaninamide, Signal transducer and activator of transcription 5A | | 著者 | Meagher, J.L, Stuckey, J.A. | | 登録日 | 2022-03-15 | | 公開日 | 2023-02-15 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.352 Å) | | 主引用文献 | Discovery of a Potent and Selective STAT5 PROTAC Degrader with Strong Antitumor Activity In Vivo in Acute Myeloid Leukemia.
J.Med.Chem., 66, 2023
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7UK7
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7UKA
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7UC6
 | | Stat5a Core in complex with Compound 12 | | 分子名称: | N-{5-[difluoro(phosphono)methyl]-1-benzothiophene-2-carbonyl}-3-methyl-L-valyl-L-prolyl-N~3~-(4-bromophenyl)-N,N-dimethyl-beta-alaninamide, Signal transducer and activator of transcription 5A | | 著者 | Meagher, J.L, Stuckey, J.A. | | 登録日 | 2022-03-16 | | 公開日 | 2023-02-15 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (3.101 Å) | | 主引用文献 | Discovery of a Potent and Selective STAT5 PROTAC Degrader with Strong Antitumor Activity In Vivo in Acute Myeloid Leukemia.
J.Med.Chem., 66, 2023
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