5JIH
 
 | | Crystal structure of HER2 binding IgG1-Fc (Fcab STAB19) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-1 chain C region | | 著者 | Humm, A, Lobner, E, Mlynek, G, Obinger, C, Djinovic-Carugo, K. | | 登録日 | 2016-04-22 | | 公開日 | 2017-04-12 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.663 Å) | | 主引用文献 | Fcab-HER2 Interaction: a Menage a Trois. Lessons from X-Ray and Solution Studies.
Structure, 25, 2017
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5J9Y
 | | EGFR-T790M in complex with pyrazolopyrimidine inhibitor 1b | | 分子名称: | (R)-1-(3-(4-amino-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one, Epidermal growth factor receptor | | 著者 | Becker, C, Engel, J, Rauh, D. | | 登録日 | 2016-04-11 | | 公開日 | 2016-08-17 | | 最終更新日 | 2016-09-07 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Insight into the Inhibition of Drug-Resistant Mutants of the Receptor Tyrosine Kinase EGFR.
Angew.Chem.Int.Ed.Engl., 55, 2016
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4F7U
 | | The 6S snRNP assembly intermediate | | 分子名称: | HEXAETHYLENE GLYCOL, Methylosome subunit pICln, Small nuclear ribonucleoprotein E, ... | | 著者 | Grimm, C, Pelz, J.P. | | 登録日 | 2012-05-16 | | 公開日 | 2013-01-30 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.898 Å) | | 主引用文献 | Structural Basis of Assembly Chaperone- Mediated snRNP Formation.
Mol.Cell, 49, 2013
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4F7O
 | | Crystal structure of CSN5 | | 分子名称: | COP9 signalosome complex subunit 5, THIOCYANATE ION, ZINC ION | | 著者 | Echalier, A, Birol, M, Hoh, F, Dumas, C. | | 登録日 | 2012-05-16 | | 公開日 | 2013-01-23 | | 最終更新日 | 2013-02-06 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Insights into the regulation of the human COP9 signalosome catalytic subunit, CSN5/Jab1.
Proc.Natl.Acad.Sci.USA, 110, 2013
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8VBZ
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8VEQ
 | | Crystal structure of transpeptidase domain of PBP2 from Neisseria gonorrhoeae cephalosporin-resistant strain H041 in complex with azlocillin | | 分子名称: | (2R,4S)-5,5-dimethyl-2-[(1R)-2-oxo-1-{[(2R)-2-{[(2-oxoimidazolidin-1-yl)carbonyl]amino}-2-phenylacetyl]amino}ethyl]-1,3-thiazolidine-4-carboxylic acid, Probable peptidoglycan D,D-transpeptidase PenA | | 著者 | Stratton, C, Bala, S, Davies, C. | | 登録日 | 2023-12-20 | | 公開日 | 2024-03-20 | | 最終更新日 | 2024-04-24 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Ureidopenicillins Are Potent Inhibitors of Penicillin-Binding Protein 2 from Multidrug-Resistant Neisseria gonorrhoeae H041.
Acs Infect Dis., 10, 2024
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4FBM
 | | LipS and LipT, two metagenome-derived lipolytic enzymes increase the diversity of known lipase and esterase families | | 分子名称: | BROMIDE ION, LipS lipolytic enzyme | | 著者 | Chow, J, Krauss, U, Dall Antonia, Y, Fersini, F, Schmeisser, C, Schmidt, M, Menyes, I, Bornscheuer, U, Lauinger, B, Bongen, P, Pietruszka, J, Eckstein, M, Thum, O, Liese, A, Mueller-Dieckmann, J, Jaeger, K.-E, Kovavic, F, Streit, W.R, Structural Proteomics in Europe (SPINE) | | 登録日 | 2012-05-23 | | 公開日 | 2012-10-10 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | The Metagenome-Derived Enzymes LipS and LipT Increase the Diversity of Known Lipases.
Plos One, 7, 2012
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8VEN
 | | Crystal structure of transpeptidase domain of PBP2 from Neisseria gonorrhoeae cephalosporin-resistant strain H041 in complex with cefoperazone | | 分子名称: | (2R,4R)-2-[(1R)-1-{[(2R)-2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-2-(4-hydroxyphenyl)acetyl]amino}-2-oxoethyl]-5-methylidene-1,3-thiazinane-4-carboxylic acid, Probable peptidoglycan D,D-transpeptidase PenA | | 著者 | Stratton, C, Bala, S, Davies, C. | | 登録日 | 2023-12-20 | | 公開日 | 2024-03-20 | | 最終更新日 | 2024-04-24 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Ureidopenicillins Are Potent Inhibitors of Penicillin-Binding Protein 2 from Multidrug-Resistant Neisseria gonorrhoeae H041.
Acs Infect Dis., 10, 2024
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4FBL
 | | LipS and LipT, two metagenome-derived lipolytic enzymes increase the diversity of known lipase and esterase families | | 分子名称: | CHLORIDE ION, LipS lipolytic enzyme, SPERMIDINE | | 著者 | Chow, J, Krauss, U, Dall Antonia, Y, Fersini, F, Schmeisser, C, Schmidt, M, Menyes, I, Bornscheuer, U, Lauinger, B, Bongen, P, Pietruszka, J, Eckstein, M, Thum, O, Liese, A, Mueller-Dieckmann, J, Jaeger, K.-E, Kovacic, F, Streit, W.R, Structural Proteomics in Europe (SPINE) | | 登録日 | 2012-05-23 | | 公開日 | 2012-10-10 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | | 主引用文献 | The Metagenome-Derived Enzymes LipS and LipT Increase the Diversity of Known Lipases.
Plos One, 7, 2012
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1F27
 | | CRYSTAL STRUCTURE OF A BIOTIN-BINDING RNA PSEUDOKNOT | | 分子名称: | BIOTIN, MAGNESIUM ION, RNA (5'-R(*AP*AP*AP*AP*AP*GP*UP*CP*CP*UP*C)-3'), ... | | 著者 | Nix, J, Sussman, D, Wilson, C. | | 登録日 | 2000-05-23 | | 公開日 | 2000-06-12 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | The 1.3 A crystal structure of a biotin-binding pseudoknot and the basis for RNA molecular recognition.
J.Mol.Biol., 296, 2000
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1F4L
 | | CRYSTAL STRUCTURE OF THE E.COLI METHIONYL-TRNA SYNTHETASE COMPLEXED WITH METHIONINE | | 分子名称: | METHIONINE, METHIONYL-TRNA SYNTHETASE, ZINC ION | | 著者 | Serre, L, Verdon, G, Chonowski, T, Hervouet, N, Zelwer, C. | | 登録日 | 2000-06-08 | | 公開日 | 2001-03-21 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | How methionyl-tRNA synthetase creates its amino acid recognition pocket upon L-methionine binding.
J.Mol.Biol., 306, 2001
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1F3V
 | | Crystal structure of the complex between the N-terminal domain of TRADD and the TRAF domain of TRAF2 | | 分子名称: | TUMOR NECROSIS FACTOR RECEPTOR TYPE 1 ASSOCIATED DEATH DOMAIN PROTEIN, TUMOR NECROSIS FACTOR RECEPTOR-ASSOCIATED PROTEIN | | 著者 | Park, Y.C, Ye, H, Hsia, C, Segal, D, Rich, R, Liou, H.-C, Myszka, D, Wu, H. | | 登録日 | 2000-06-06 | | 公開日 | 2000-09-06 | | 最終更新日 | 2017-10-04 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction.
Cell(Cambridge,Mass.), 101, 2000
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1F0X
 | | CRYSTAL STRUCTURE OF D-LACTATE DEHYDROGENASE, A PERIPHERAL MEMBRANE RESPIRATORY ENZYME. | | 分子名称: | D-LACTATE DEHYDROGENASE, FLAVIN-ADENINE DINUCLEOTIDE | | 著者 | Dym, O, Pratt, E.A, Ho, C, Eisenberg, D. | | 登録日 | 2000-05-17 | | 公開日 | 2000-08-23 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The crystal structure of D-lactate dehydrogenase, a peripheral membrane respiratory enzyme.
Proc.Natl.Acad.Sci.USA, 97, 2000
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1F42
 | | THE P40 DOMAIN OF HUMAN INTERLEUKIN-12 | | 分子名称: | 5-MERCAPTO-2-NITRO-BENZOIC ACID, INTERLEUKIN-12 BETA CHAIN, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Yoon, C, Johnston, S.C, Tang, J, Tobin, J.F, Somers, W.S. | | 登録日 | 2000-06-07 | | 公開日 | 2001-06-13 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12.
EMBO J., 19, 2000
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1F0Z
 | | SOLUTION STRUCTURE OF THIS, THE SULFUR CARRIER PROTEIN IN E.COLI THIAMIN BIOSYNTHESIS | | 分子名称: | THIS PROTEIN | | 著者 | Wang, C, Xi, J, Begley, T.P, Nicholson, L.K. | | 登録日 | 2000-05-17 | | 公開日 | 2001-01-10 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of ThiS and implications for the evolutionary roots of ubiquitin.
Nat.Struct.Biol., 8, 2001
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3L16
 | | Discovery of (thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer | | 分子名称: | 5-(6-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)pyridin-2-amine, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | | 著者 | Murray, J.M, Wiesmann, C. | | 登録日 | 2009-12-10 | | 公開日 | 2010-02-16 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Discovery of (Thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer.
J.Med.Chem., 53, 2010
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3KMS
 | | G62S mutant of foot-and-mouth disease virus RNA-polymerase in complex with a template- primer RNA trigonal structure | | 分子名称: | 3D polymerase, MAGNESIUM ION, RNA (5'-R(*AP*UP*GP*GP*GP*CP*C)-3'), ... | | 著者 | Ferrer-Orta, C, Verdaguer, N, Perez-Luque, R. | | 登録日 | 2009-11-11 | | 公開日 | 2010-07-07 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structure of foot-and-mouth disease virus mutant polymerases with reduced sensitivity to ribavirin
J.Virol., 84, 2010
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1F6T
 | | STRUCTURE OF THE NUCLEOSIDE DIPHOSPHATE KINASE/ALPHA-BORANO(RP)-TDP.MG COMPLEX | | 分子名称: | 2*-DEOXY-THYMIDINE-5*-ALPHA BORANO DIPHOSPHATE (ISOMER RP), MAGNESIUM ION, PROTEIN (NUCLEOSIDE DIPHOSPHATE KINASE) | | 著者 | Guerreiro, C, Boretto, J, Janin, J, Veron, M, Canard, B, Schneider, B, Sarfati, S, Deville-Bonne, D. | | 登録日 | 2000-06-23 | | 公開日 | 2000-09-13 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | | 主引用文献 | Structural basis for activation of alpha-boranophosphate nucleotide analogues targeting drug-resistant reverse transcriptase.
EMBO J., 19, 2000
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1FG2
 | | CRYSTAL STRUCTURE OF THE LCMV PEPTIDIC EPITOPE GP33 IN COMPLEX WITH THE MURINE CLASS I MHC MOLECULE H-2DB | | 分子名称: | BETA-2 MICROGLOBULIN, H-2 CLASS I HISTOCOMPATIBILITY ANTIGEN, D-B ALPHA CHAIN, ... | | 著者 | Tissot, A.C, Ciatto, C, Mittl, P.R.E, Gruetter, M.G, Plueckthun, A. | | 登録日 | 2000-07-27 | | 公開日 | 2000-10-04 | | 最終更新日 | 2022-12-21 | | 実験手法 | X-RAY DIFFRACTION (2.754 Å) | | 主引用文献 | Viral escape at the molecular level explained by quantitative T-cell receptor/peptide/MHC interactions and the crystal structure of a peptide/MHC complex.
J.Mol.Biol., 302, 2000
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1FJJ
 | | CRYSTAL STRUCTURE OF E.COLI YBHB PROTEIN, A NEW MEMBER OF THE MAMMALIAN PEBP FAMILY | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, HYPOTHETICAL 17.1 KDA PROTEIN IN MODC-BIOA INTERGENIC REGION | | 著者 | Serre, L, Pereira de Jesus, K, Benedetti, H, Bureaud, N, Schoentgen, F, Zelwer, C. | | 登録日 | 2000-08-08 | | 公開日 | 2001-07-18 | | 最終更新日 | 2017-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | | 主引用文献 | Crystal structures of YBHB and YBCL from Escherichia coli, two bacterial homologues to a Raf kinase inhibitor protein.
J.Mol.Biol., 310, 2001
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1FNL
 | | CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF A HUMAN FCGRIII | | 分子名称: | LOW AFFINITY IMMUNOGLOBULIN GAMMA FC REGION RECEPTOR III-B, MERCURY (II) ION | | 著者 | Zhang, Y, Boesen, C.C, Radaev, S, Brooks, A.G, Fridman, W.H, Sautes-Fridman, C, Sun, P.D. | | 登録日 | 2000-08-22 | | 公開日 | 2000-11-22 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal structure of the extracellular domain of a human Fc gamma RIII.
Immunity, 13, 2000
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1F7Y
 | | THE CRYSTAL STRUCTURE OF TWO UUCG LOOPS HIGHLIGHTS THE ROLE PLAYED BY 2'-HYDROXYL GROUPS IN ITS UNUSUAL STABILITY | | 分子名称: | 16S RIBOSOMAL RNA FRAGMENT, 30S RIBOSOMAL PROTEIN S15, MAGNESIUM ION, ... | | 著者 | Ennifar, E, Nikouline, A, Serganov, A, Tishchenko, S, Nevskaya, N, Garber, M, Ehresmann, B, Ehresmann, C, Nikonov, S, Dumas, P. | | 登録日 | 2000-06-28 | | 公開日 | 2000-11-22 | | 最終更新日 | 2021-11-03 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | The crystal structure of UUCG tetraloop.
J.Mol.Biol., 304, 2000
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5FA6
 | | wild type human CYPOR | | 分子名称: | FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | 著者 | Xia, C, Marohnic, C, Panda, S, Masters, B.S, Kim, J.J.K. | | 登録日 | 2015-12-11 | | 公開日 | 2016-08-17 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Instability of the Human Cytochrome P450 Reductase A287P Variant Is the Major Contributor to Its Antley-Bixler Syndrome-like Phenotype.
J.Biol.Chem., 291, 2016
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1FT7
 | | AAP COMPLEXED WITH L-LEUCINEPHOSPHONIC ACID | | 分子名称: | BACTERIAL LEUCYL AMINOPEPTIDASE, LEUCINE PHOSPHONIC ACID, POTASSIUM ION, ... | | 著者 | Stamper, C, Bennett, B, Holz, R, Petsko, G, Ringe, D. | | 登録日 | 2000-09-11 | | 公開日 | 2000-10-04 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Inhibition of the aminopeptidase from Aeromonas proteolytica by L-leucinephosphonic acid. Spectroscopic and crystallographic characterization of the transition state of peptide hydrolysis.
Biochemistry, 40, 2001
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1F9X
 | | AVERAGE NMR SOLUTION STRUCTURE OF THE BIR-3 DOMAIN OF XIAP | | 分子名称: | INHIBITOR OF APOPTOSIS PROTEIN XIAP, ZINC ION | | 著者 | Sun, C, Cai, M, Meadows, R.P, Fesik, S.W. | | 登録日 | 2000-07-11 | | 公開日 | 2001-07-11 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | NMR structure and mutagenesis of the third Bir domain of the inhibitor of apoptosis protein XIAP.
J.Biol.Chem., 275, 2000
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