7F0I
| phosphodiesterase-9A in complex with inhibitor 4b | 分子名称: | 1-cyclopentyl-6-[[(2R)-1-(6-fluoranyl-2-azaspiro[3.3]heptan-2-yl)-1-oxidanylidene-propan-2-yl]amino]-5H-pyrazolo[3,4-d]pyrimidin-4-one, Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, MAGNESIUM ION, ... | 著者 | Wu, Y, Huang, Y.Y, Luo, H.B. | 登録日 | 2021-06-04 | 公開日 | 2022-04-13 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.70000887 Å) | 主引用文献 | Discovery of Potent Phosphodiesterase-9 Inhibitors for the Treatment of Hepatic Fibrosis J.Med.Chem., 64, 2021
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7F1E
| Structure of METTL6 bound with SAM | 分子名称: | S-ADENOSYLMETHIONINE, tRNA N(3)-methylcytidine methyltransferase METTL6 | 著者 | Li, S, Liao, S, Xu, C. | 登録日 | 2021-06-09 | 公開日 | 2022-01-12 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.589 Å) | 主引用文献 | Structural basis for METTL6-mediated m3C RNA methylation. Biochem.Biophys.Res.Commun., 589, 2021
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7D2Y
| complex of two RRM domains | 分子名称: | Embryonic developmental protein tofu-6, RRM2, SULFATE ION | 著者 | Wang, X, Liao, S, Xu, C. | 登録日 | 2020-09-17 | 公開日 | 2021-08-25 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | 主引用文献 | Molecular basis for PICS-mediated piRNA biogenesis and cell division. Nat Commun, 12, 2021
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7CNG
| Structure of CDK5R1 bound FEM1B | 分子名称: | Protein fem-1 homolog B,Peptide from Cyclin-dependent kinase 5 activator 1, SULFATE ION | 著者 | Chen, X, Liao, S, Xu, C. | 登録日 | 2020-07-31 | 公開日 | 2020-10-21 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.49 Å) | 主引用文献 | Molecular basis for arginine C-terminal degron recognition by Cul2 FEM1 E3 ligase. Nat.Chem.Biol., 17, 2021
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7EJS
| Structure of ERH-2 bound to PICS-1 | 分子名称: | Enhancer of rudimentary homolog 2,Protein pid-3 | 著者 | Wang, X, Xu, C. | 登録日 | 2021-04-02 | 公開日 | 2021-08-25 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.387 Å) | 主引用文献 | Molecular basis for PICS-mediated piRNA biogenesis and cell division. Nat Commun, 12, 2021
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7EJO
| Structure of ERH-2 bound to TOST-1 | 分子名称: | Enhancer of rudimentary homolog 2, Enhancer of rudimentary homolog 2,Protein tost-1 | 著者 | Wang, X, Xu, C. | 登録日 | 2021-04-02 | 公開日 | 2021-08-25 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.191 Å) | 主引用文献 | Molecular basis for PICS-mediated piRNA biogenesis and cell division. Nat Commun, 12, 2021
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7FAW
| Structure of LW domain from Yeast | 分子名称: | Transcription elongation factor S-II | 著者 | Liao, S, Gao, J, Tu, X. | 登録日 | 2021-07-07 | 公開日 | 2022-07-13 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.438 Å) | 主引用文献 | Structural basis for evolutionarily conserved interactions between TFIIS and Paf1C. Int.J.Biol.Macromol., 253, 2023
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7VP9
| Crystal structure of human ClpP in complex with ZG111 | 分子名称: | (6S,9aS)-N-[(4-bromophenyl)methyl]-6-[(2S)-butan-2-yl]-8-(naphthalen-1-ylmethyl)-4,7-bis(oxidanylidene)-3,6,9,9a-tetrahydro-2H-pyrazino[1,2-a]pyrimidine-1-carboxamide, ATP-dependent Clp protease proteolytic subunit, mitochondrial, ... | 著者 | Wang, P.Y, Gan, J.H, Yang, C.-G. | 登録日 | 2021-10-15 | 公開日 | 2022-06-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.552 Å) | 主引用文献 | Aberrant human ClpP activation disturbs mitochondrial proteome homeostasis to suppress pancreatic ductal adenocarcinoma. Cell Chem Biol, 29, 2022
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7XQ5
| Crystal structure of ScIno2p-ScIno4p bound promoter DNA | 分子名称: | DNA (5'-D(*GP*AP*TP*TP*TP*TP*CP*AP*CP*AP*TP*GP*CP*AP*G)-3'), DNA (5'-D(P*CP*CP*TP*GP*CP*AP*TP*GP*TP*GP*AP*AP*AP*AP*T)-3'), HEXANE-1,6-DIOL, ... | 著者 | Khan, M.H, Lu, X. | 登録日 | 2022-05-06 | 公開日 | 2022-07-20 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Structural Analysis of Ino2p/Ino4p Mutual Interactions and Their Binding Interface with Promoter DNA. Int J Mol Sci, 23, 2022
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7X39
| Structure of CIZ1 bound ERH | 分子名称: | Enhancer of rudimentary homolog,Cip1-interacting zinc finger protein | 著者 | Wang, X, Xu, C. | 登録日 | 2022-02-28 | 公開日 | 2022-08-31 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Molecular basis for the recognition of CIZ1 by ERH. Febs J., 290, 2023
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7V5Y
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7V5Z
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7V6W
| Crystal structure of heterohexameric Sa2YoeB-Sa2YefM complex bound to 26bp-DNA | 分子名称: | Antitoxin, DNA (25-MER), DNA (26-MER), ... | 著者 | Xue, L, Khan, M.H, Yue, J. | 登録日 | 2021-08-20 | 公開日 | 2021-12-15 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | The two paralogous copies of the YoeB-YefM toxin-antitoxin module in Staphylococcus aureus differ in DNA binding and recognition patterns. J.Biol.Chem., 298, 2022
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7XGW
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7YCV
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7YCU
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7YCW
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7YCS
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7YF2
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7Y9C
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7YF4
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7YF3
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2GVF
| HCV NS3-4A protease domain complexed with a macrocyclic ketoamide inhibitor, SCH419021 | 分子名称: | (6R,8S,11S)-11-CYCLOHEXYL-N-(1-{[(2-{[(1S)-2-(DIMETHYLAMINO)-2-OXO-1-PHENYLETHYL]AMINO}-2-OXOETHYL)AMINO](OXO)ACETYL}BUTYL)-10,13-DIOXO-2,5-DIOXA-9,12-DIAZATRICYCLO[14.3.1.1~6,9~]HENICOSA-1(20),16,18-TRIENE-8-CARBOXAMIDE, Polyprotein, ZINC ION, ... | 著者 | Arasappan, A, Njoroge, F.G, Chen, K.X, Venkatraman, S, Parekh, T.N, Gu, H, Pichardo, J, Butkiewicz, N, Prongay, A, Madison, V, Girijavallabhan, V. | 登録日 | 2006-05-02 | 公開日 | 2007-01-23 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | P2-P4 macrocyclic inhibitors of hepatitis C virus NS3-4A serine protease. Bioorg.Med.Chem.Lett., 16, 2006
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