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2B4G
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dihydroorotate dehydrogenase
分子名称: BROMIDE ION, FLAVIN MONONUCLEOTIDE, GLYCEROL, ...
著者Arakaki, T.L, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
登録日2005-09-23
公開日2005-10-11
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies
Mol.Microbiol., 68, 2008
4ENN
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BU of 4enn by Molmil
Crystal structure of S. pombe Atl1 in complex with damaged DNA containing O6-carboxymethylguanine
分子名称: Alkyltransferase-like protein 1, RNA (5'-R(*GP*CP*CP*AP*TP*GP*(C6G)P*CP*TP*AP*GP*TP*A)-3')
著者Tubbs, J.L, Arvai, A.S, Tainer, J.A.
登録日2012-04-13
公開日2012-06-20
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.8448 Å)
主引用文献Atl1 Regulates Choice between Global Genome and Transcription-Coupled Repair of O(6)-Alkylguanines.
Mol.Cell, 47, 2012
4HDV
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Crystal structure of S. pombe ATL1 in complex with damaged DNA containing 2,6-diaminopurine
分子名称: 5'-D(*CP*TP*AP*CP*TP*AP*GP*CP*CP*AP*TP*GP*G)-3', 5'-D(*GP*CP*CP*AP*TP*GP*(1AP)P*CP*TP*AP*GP*TP*A)-3', Alkyltransferase-like protein 1
著者Tubbs, J.L, Tainer, J.A.
登録日2012-10-02
公開日2012-12-26
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.702 Å)
主引用文献Alkyltransferase-like protein (Atl1) distinguishes alkylated guanines for DNA repair using cation-{pi} interactions.
Proc.Natl.Acad.Sci.USA, 109, 2012
4ENM
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Crystal structure of S. pombe Atl1 in complex with damaged DNA containing O6-benzylguanine
分子名称: Alkyltransferase-like protein 1, DNA (5'-D(*CP*TP*AP*CP*TP*AP*GP*CP*CP*AP*TP*GP*G)-3'), DNA (5'-D(*GP*CP*CP*AP*TP*GP*(BZG)P*CP*TP*AP*GP*TP*A)-3')
著者Tubbs, J.L, Arvai, A.S, Tainer, J.A.
登録日2012-04-13
公開日2012-06-20
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.8402 Å)
主引用文献Atl1 Regulates Choice between Global Genome and Transcription-Coupled Repair of O(6)-Alkylguanines.
Mol.Cell, 47, 2012
4ENK
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Crystal structure of S. pombe Atl1 in complex with damaged DNA containing O6-propylguanine
分子名称: Alkyltransferase-like protein 1, DNA (5'-D(*CP*TP*AP*CP*TP*AP*GP*CP*CP*AP*TP*GP*G)-3'), DNA (5'-D(*GP*CP*CP*AP*TP*GP*(6PO)P*CP*TP*AP*GP*TP*A)-3')
著者Tubbs, J.L, Arvai, A.S, Tainer, J.A.
登録日2012-04-13
公開日2012-06-20
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3.0445 Å)
主引用文献Atl1 Regulates Choice between Global Genome and Transcription-Coupled Repair of O(6)-Alkylguanines.
Mol.Cell, 47, 2012
4ENJ
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Crystal structure of S. pombe Atl1 in complex with damaged DNA containing O6-hydroxyethylguanine
分子名称: Alkyltransferase-like protein 1, DNA (5'-D(*CP*TP*AP*CP*TP*AP*GP*CP*CP*AP*TP*GP*G)-3'), DNA (5'-D(*GP*CP*CP*AP*TP*GP*(EHG)P*CP*TP*AP*GP*TP*A)-3')
著者Tubbs, J.L, Arvai, A.S, Tainer, J.A.
登録日2012-04-13
公開日2012-06-20
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3.0989 Å)
主引用文献Atl1 Regulates Choice between Global Genome and Transcription-Coupled Repair of O(6)-Alkylguanines.
Mol.Cell, 47, 2012
4HDU
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Crystal structure of S. pombe ATL1 in complex with damaged DNA containing 2-aminopurine
分子名称: 5'-D(*CP*TP*AP*CP*TP*AP*GP*CP*CP*AP*TP*GP*G)-3', 5'-D(*GP*CP*CP*AP*TP*GP*(2PR)P*CP*TP*AP*GP*TP*A)-3', Alkyltransferase-like protein 1
著者Tubbs, J.L, Tainer, J.A.
登録日2012-10-02
公開日2012-12-26
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.848 Å)
主引用文献Alkyltransferase-like protein (Atl1) distinguishes alkylated guanines for DNA repair using cation-{pi} interactions.
Proc.Natl.Acad.Sci.USA, 109, 2012
4GGN
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Malaria invasion machinery protein complex
分子名称: Myosin A tail domain interacting protein MTIP, Myosin-A
著者Khamrui, S, Turley, S, Bergman, L.W, Hol, W.G.J.
登録日2012-08-06
公開日2013-07-03
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.29 Å)
主引用文献The structure of the D3 domain of Plasmodium falciparum myosin tail interacting protein MTIP in complex with a nanobody.
Mol.Biochem.Parasitol., 190, 2013
1GYQ
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BU of 1gyq by Molmil
CRYSTAL STRUCTURE OF GLYCOSOMAL GLYCERALDEHYDE FROM LEISHMANIA MEXICANA IN COMPLEX WITH N6-BENZYL-NAD
分子名称: N6-BENZYL-NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PROTEIN (GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE)
著者Suresh, S, Hol, W.
登録日1999-03-05
公開日1999-03-16
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Structure-based design of submicromolar, biologically active inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase.
Proc.Natl.Acad.Sci.USA, 96, 1999
2TDX
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BU of 2tdx by Molmil
DIPHTHERIA TOX REPRESSOR (C102D MUTANT) COMPLEXED WITH NICKEL
分子名称: DIPHTHERIA TOX REPRESSOR, NICKEL (II) ION
著者White, A, Ding, X, Zheng, H, Schiering, N, Ringe, D, Murphy, J.R.
登録日1998-06-22
公開日1998-10-14
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structure of the metal-ion-activated diphtheria toxin repressor/tox operator complex.
Nature, 394, 1998
4MX9
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CDPK1 from Neospora caninum in complex with inhibitor UW1294
分子名称: 3-(6-ethoxynaphthalen-2-yl)-1-[(1-methylpiperidin-4-yl)methyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-like domain protein kinase isoenzyme gamma, related
著者Merritt, E.A.
登録日2013-09-26
公開日2013-10-09
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Neospora caninum Calcium-Dependent Protein Kinase 1 Is an Effective Drug Target for Neosporosis Therapy.
Plos One, 9, 2014
1JQY
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BU of 1jqy by Molmil
HEAT-LABILE ENTEROTOXIN B-PENTAMER WITH LIGAND BMSC-0010
分子名称: (3-NITRO-5-(3-MORPHOLIN-4-YL-PROPYLAMINOCARBONYL)PHENYL)-GALACTOPYRANOSIDE, HEAT-LABILE ENTEROTOXIN B CHAIN
著者Merritt, E.A, Hol, W.G.J.
登録日2001-08-09
公開日2002-05-08
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (2.14 Å)
主引用文献Anchor-based design of improved cholera toxin and E. coli heat-labile enterotoxin receptor binding antagonists that display multiple binding modes.
Chem.Biol., 9, 2002
1JR0
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BU of 1jr0 by Molmil
CHOLERA TOXIN B-PENTAMER WITH LIGAND BMSC-0011
分子名称: (3-NITRO-5-(2-MORPHOLIN-4-YL-ETHYLAMINOCARBONYL)PHENYL)-GALACTOPYRANOSIDE, cholera toxin B subunit
著者Merritt, E.A, Hol, W.G.J.
登録日2001-08-09
公開日2002-05-08
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Anchor-based design of improved cholera toxin and E. coli heat-labile enterotoxin receptor binding antagonists that display multiple binding modes.
Chem.Biol., 9, 2002
4M97
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BU of 4m97 by Molmil
Calcium-Dependent Protein Kinase 1 from Neospora caninum
分子名称: Calmodulin-like domain protein kinase isoenzyme gamma, related
著者Merritt, E.A.
登録日2013-08-14
公開日2013-10-02
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Neospora caninum Calcium-Dependent Protein Kinase 1 Is an Effective Drug Target for Neosporosis Therapy.
Plos One, 9, 2014
1BI2
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BU of 1bi2 by Molmil
STRUCTURE OF APO-AND HOLO-DIPHTHERIA TOXIN REPRESSOR
分子名称: DIPHTHERIA TOXIN REPRESSOR
著者Pohl, E, Hol, W.G.J.
登録日1998-06-21
公開日1999-06-22
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Motion of the DNA-binding domain with respect to the core of the diphtheria toxin repressor (DtxR) revealed in the crystal structures of apo- and holo-DtxR.
J.Biol.Chem., 273, 1998
1BI0
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STRUCTURE OF APO-AND HOLO-DIPHTHERIA TOXIN REPRESSOR
分子名称: DIPHTHERIA TOXIN REPRESSOR, SULFATE ION, ZINC ION
著者Pohl, E, Hol, W.G.
登録日1998-06-21
公開日1999-07-22
最終更新日2022-12-21
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Motion of the DNA-binding domain with respect to the core of the diphtheria toxin repressor (DtxR) revealed in the crystal structures of apo- and holo-DtxR.
J.Biol.Chem., 273, 1998
1BI1
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BU of 1bi1 by Molmil
STRUCTURE OF APO-AND HOLO-DIPHTHERIA TOXIN REPRESSOR
分子名称: DIPHTHERIA TOXIN REPRESSOR
著者Pohl, E, Hol, W.G.J.
登録日1998-06-21
公開日1999-06-22
最終更新日2022-12-21
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Motion of the DNA-binding domain with respect to the core of the diphtheria toxin repressor (DtxR) revealed in the crystal structures of apo- and holo-DtxR.
J.Biol.Chem., 273, 1998
1BI3
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BU of 1bi3 by Molmil
STRUCTURE OF APO-AND HOLO-DIPHTHERIA TOXIN REPRESSOR
分子名称: DIPHTHERIA TOXIN REPRESSOR, SULFATE ION, ZINC ION
著者Pohl, E, Hol, W.G.J.
登録日1998-06-21
公開日1999-06-22
最終更新日2022-12-21
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Motion of the DNA-binding domain with respect to the core of the diphtheria toxin repressor (DtxR) revealed in the crystal structures of apo- and holo-DtxR.
J.Biol.Chem., 273, 1998
6E8Z
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Binary complex of Human glycerol 3-phosphate dehydrogenase with NAD
分子名称: 1,2-ETHANEDIOL, Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic, ...
著者Mydy, L.S, Gulick, A.M.
登録日2018-07-31
公開日2019-01-30
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Human Glycerol 3-Phosphate Dehydrogenase: X-ray Crystal Structures That Guide the Interpretation of Mutagenesis Studies.
Biochemistry, 58, 2019
4UFP
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BU of 4ufp by Molmil
Laboratory evolved variant R-C1B1D33 of potato epoxide hydrolase StEH1
分子名称: EPOXIDE HYDROLASE
著者Carlsson, A.J, Bauer, P, Nilsson, M, Dobritzsch, D, Kamerlin, S.C.L, Widersten, M.
登録日2015-03-17
公開日2016-04-13
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献Laboratory Evolved Enzymes Provide Snapshots of the Development of Enantioconvergence in Enzyme-Catalyzed Epoxide Hydrolysis.
Chembiochem, 17, 2016
4UFO
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BU of 4ufo by Molmil
Laboratory evolved variant R-C1B1D33E6 of potato epoxide hydrolase StEH1
分子名称: EPOXIDE HYDROLASE
著者Carlsson, A.J, Bauer, P, Nilsson, M, Dobritzsch, D, Kamerlin, S.C.L, Widersten, M.
登録日2015-03-17
公開日2016-04-13
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献Laboratory Evolved Enzymes Provide Snapshots of the Development of Enantioconvergence in Enzyme-Catalyzed Epoxide Hydrolysis.
Chembiochem, 17, 2016
4YSJ
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BU of 4ysj by Molmil
Calcium-Dependent Protein Kinase from Eimeria tenella in complex with ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Calmodulin-like domain protein kinase, ...
著者Merritt, E.A.
登録日2015-03-17
公開日2016-04-06
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献CDPK is a druggable target in the apicomplexan parasite Eimeria
to be published
4YJN
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BU of 4yjn by Molmil
Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1639
分子名称: 5-amino-1-tert-butyl-3-[2-(cyclobutyloxy)quinolin-6-yl]-1H-pyrazole-4-carboxamide, Calmodulin-domain protein kinase 1
著者Merritt, E.A.
登録日2015-03-03
公開日2015-11-25
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1.
Acs Med.Chem.Lett., 6, 2015
6XEA
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BU of 6xea by Molmil
Crystal Structure of the PTP1B YopH WPD loop Chimera 3 bound to vanadate
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BENZAMIDINE, MAGNESIUM ION, ...
著者Olsen, K.J, Shen, R, Johnson, S.J, Hengge, A.C.
登録日2020-06-12
公開日2021-12-15
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.549 Å)
主引用文献Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases.
Chem Sci, 13, 2022
6XEE
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BU of 6xee by Molmil
Crystal Structure of the PTP1B YopH WPD loop Chimera 4 apo form
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BENZAMIDINE, DI(HYDROXYETHYL)ETHER, ...
著者Olsen, K.J, Shen, R, Johnson, S.J, Hengge, A.C.
登録日2020-06-12
公開日2021-12-15
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.501 Å)
主引用文献Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases.
Chem Sci, 13, 2022

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