5NVA
 
 | | Substrate-bound outward-open state of a Na+-coupled sialic acid symporter reveals a novel Na+-site | | Descriptor: | N-acetyl-beta-neuraminic acid, Putative sodium:solute symporter, SODIUM ION | | Authors: | Wahlgren, W.Y, North, R.A, Dunevall, E, Goyal, P, Grabe, M, Dobson, R, Abramson, J, Ramaswamy, S, Friemann, R. | | Deposit date: | 2017-05-03 | | Release date: | 2018-04-04 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.26 Å) | | Cite: | Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+site.
Nat Commun, 9, 2018
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5NV9
 | | Substrate-bound outward-open state of a Na+-coupled sialic acid symporter reveals a novel Na+-site | | Descriptor: | DODECYL-BETA-D-MALTOSIDE, N-acetyl-beta-neuraminic acid, PHOSPHATE ION, ... | | Authors: | Wahlgren, W.Y, North, R.A, Dunevall, E, Paz, A, Goyal, P, Bisignano, P, Grabe, M, Dobson, R, Abramson, J, Ramaswamy, S, Friemann, R. | | Deposit date: | 2017-05-03 | | Release date: | 2018-04-04 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+site.
Nat Commun, 9, 2018
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2XQ2
 | | Structure of the K294A mutant of vSGLT | | Descriptor: | DI(HYDROXYETHYL)ETHER, SODIUM/GLUCOSE COTRANSPORTER | | Authors: | Watanabe, A, Choe, S, Chaptal, V, Rosenberg, J.M, Wright, E.M, Grabe, M, Abramson, J. | | Deposit date: | 2010-09-01 | | Release date: | 2010-12-08 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.73 Å) | | Cite: | The Mechanism of Sodium and Substrate Release from the Binding Pocket of Vsglt
Nature, 468, 2010
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3RQ7
 | | Polo-like kinase 1 Polo box domain in complex with a C6H5(CH2)8-derivatized peptide inhibitor | | Descriptor: | C6H5(CH2)8-derivatized peptide inhibitor, Serine/threonine-protein kinase PLK1 | | Authors: | Liu, F, Park, J.-E, Qian, W.-J, Lim, D.C, Graber, M, Berg, T, Yaffe, M.B, Lee, K.S, Burke Jr, T.R. | | Deposit date: | 2011-04-27 | | Release date: | 2011-07-20 | | Last modified: | 2012-12-12 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel.
Nat.Chem.Biol., 7, 2011
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3TC5
 | | Selective targeting of disease-relevant protein binding domains by O-phosphorylated natural product derivatives | | Descriptor: | (11alpha,16alpha)-9-fluoro-11,17-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl dihydrogen phosphate, HEXAETHYLENE GLYCOL, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | | Authors: | Graeber, M, Janczyk, W, Sperl, B, Elumalai, N, Kozany, C, Hausch, F, Holak, T.A, Berg, T. | | Deposit date: | 2011-08-08 | | Release date: | 2011-08-31 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Selective targeting of disease-relevant protein binding domains by o-phosphorylated natural product derivatives.
Acs Chem.Biol., 6, 2011
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7JH6
 | | De novo designed two-domain di-Zn(II) and porphyrin-binding protein | | Descriptor: | NONAETHYLENE GLYCOL, Two-domain di-Zn(II) and porphyrin-binding protein, ZINC ION, ... | | Authors: | Schmidt, N, Liu, L, DeGrado, W.F. | | Deposit date: | 2020-07-20 | | Release date: | 2020-12-09 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Allosteric cooperation in a de novo-designed two-domain protein.
Proc.Natl.Acad.Sci.USA, 117, 2020
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2MUZ
 | | ssNMR structure of a designed rocker protein | | Descriptor: | designed rocker protein | | Authors: | Wang, T, Joh, N, Wu, Y, DeGrado, W.F, Hong, M. | | Deposit date: | 2014-09-18 | | Release date: | 2014-12-24 | | Last modified: | 2015-01-14 | | Method: | SOLUTION NMR | | Cite: | De novo design of a transmembrane Zn2+-transporting four-helix bundle.
Science, 346, 2014
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4MTH
 | | Crystal structure of mature human RegIIIalpha | | Descriptor: | Regenerating islet-derived protein 3-alpha 15 kDa form, ZINC ION | | Authors: | Derebe, M.G. | | Deposit date: | 2013-09-19 | | Release date: | 2013-11-27 | | Last modified: | 2017-11-15 | | Method: | X-RAY DIFFRACTION (1.47 Å) | | Cite: | Antibacterial membrane attack by a pore-forming intestinal C-type lectin.
Nature, 505, 2013
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4C69
 | | ATP binding to murine voltage-dependent anion channel 1 (mVDAC1). | | Descriptor: | 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, ADENOSINE-5'-TRIPHOSPHATE, LAURYL DIMETHYLAMINE-N-OXIDE, ... | | Authors: | Paz, A, Colletier, J.P, Abramson, J. | | Deposit date: | 2013-09-17 | | Release date: | 2014-06-04 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.277 Å) | | Cite: | Structure-Guided Simulations Illuminate the Mechanism of ATP Transport Through Vdac1.
Nat.Struct.Mol.Biol., 21, 2014
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4P6L
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4P6J
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4P6K
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7PGB
 | | NaV_Ae1/Sp1CTD_pore-SAT09 complex | | Descriptor: | 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, 4-NITROBENZOIC ACID, ... | | Authors: | Lolicato, M, Arrigoni, C. | | Deposit date: | 2021-08-13 | | Release date: | 2022-06-08 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (3.6 Å) | | Cite: | Quaternary structure independent folding of voltage-gated ion channel pore domain subunits.
Nat.Struct.Mol.Biol., 29, 2022
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7PG8
 | | NaV_Ae1/Sp1CTD_pore-ANT05 complex | | Descriptor: | ANT05 H12 fab fragment, heavy chain, light chain, ... | | Authors: | Lolicato, M, Arrigoni, C. | | Deposit date: | 2021-08-13 | | Release date: | 2022-06-08 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (4.5 Å) | | Cite: | Quaternary structure independent folding of voltage-gated ion channel pore domain subunits.
Nat.Struct.Mol.Biol., 29, 2022
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7PGF
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7PGI
 | | NaVAb1p (bicelles) | | Descriptor: | ACETATE ION, Ion transport protein, MAGNESIUM ION, ... | | Authors: | Lolicato, M, Arrigoni, C. | | Deposit date: | 2021-08-14 | | Release date: | 2022-06-08 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (3.638 Å) | | Cite: | Quaternary structure independent folding of voltage-gated ion channel pore domain subunits.
Nat.Struct.Mol.Biol., 29, 2022
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7PGH
 | | NaVAe1/Sp1CTDp (DDM) | | Descriptor: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, DODECAETHYLENE GLYCOL, DODECANE, ... | | Authors: | Lolicato, M, Arrigoni, C. | | Deposit date: | 2021-08-14 | | Release date: | 2022-06-15 | | Last modified: | 2022-06-29 | | Method: | X-RAY DIFFRACTION (4.194 Å) | | Cite: | Quaternary structure independent folding of voltage-gated ion channel pore domain subunits.
Nat.Struct.Mol.Biol., 29, 2022
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7PGG
 | | NaVAb1p detergent (DM) | | Descriptor: | 2-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}ethyl heptadecanoate, Ion transport protein | | Authors: | Lolicato, M, Arrigoni, C. | | Deposit date: | 2021-08-13 | | Release date: | 2022-06-15 | | Last modified: | 2022-06-29 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | Quaternary structure independent folding of voltage-gated ion channel pore domain subunits.
Nat.Struct.Mol.Biol., 29, 2022
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6W7D
 | | K2P2.1 (TREK-1), 10 mM K+ | | Descriptor: | CADMIUM ION, DODECANE, HEXADECANE, ... | | Authors: | Lolicato, M, Minor, D.L. | | Deposit date: | 2020-03-19 | | Release date: | 2021-01-27 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | K 2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions.
Sci Adv, 6, 2020
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6W7B
 | | K2P2.1 (TREK-1), 0 mM K+ | | Descriptor: | CADMIUM ION, DECANE, DODECANE, ... | | Authors: | Lolicato, M, Minor, D.L. | | Deposit date: | 2020-03-19 | | Release date: | 2021-01-27 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (3.88 Å) | | Cite: | K 2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions.
Sci Adv, 6, 2020
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6W84
 | | K2P2.1 (TREK-1), 200 mM K+ | | Descriptor: | CADMIUM ION, DODECANE, N-OCTANE, ... | | Authors: | Lolicato, M, Minor, D.L. | | Deposit date: | 2020-03-20 | | Release date: | 2021-01-27 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (3.7 Å) | | Cite: | K 2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions.
Sci Adv, 6, 2020
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6W8A
 | | K2P2.1 (TREK-1):ML335 complex, 10 mM K+ | | Descriptor: | CADMIUM ION, DODECANE, HEXADECANE, ... | | Authors: | Lolicato, M, Minor, D.L. | | Deposit date: | 2020-03-20 | | Release date: | 2021-01-27 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (3.002 Å) | | Cite: | K 2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions.
Sci Adv, 6, 2020
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6W8F
 | | K2P2.1 (TREK-1):ML335 complex, 0 mM K+ | | Descriptor: | CADMIUM ION, DODECANE, HEXADECANE, ... | | Authors: | Lolicato, M, Minor, D.L. | | Deposit date: | 2020-03-20 | | Release date: | 2021-01-27 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | K 2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions.
Sci Adv, 6, 2020
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6W82
 | | K2P2.1 (TREK-1), 50 mM K+ | | Descriptor: | CADMIUM ION, DECANE, DODECANE, ... | | Authors: | Lolicato, M, Minor, D.L. | | Deposit date: | 2020-03-20 | | Release date: | 2021-01-27 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (3.6 Å) | | Cite: | K 2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions.
Sci Adv, 6, 2020
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6W86
 | | K2P2.1 (TREK-1):ML335 complex, 100 mM K+ | | Descriptor: | CADMIUM ION, DECANE, DODECANE, ... | | Authors: | Lolicato, M, Minor, D.L. | | Deposit date: | 2020-03-20 | | Release date: | 2021-01-27 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (3.299 Å) | | Cite: | K 2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions.
Sci Adv, 6, 2020
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