8TAC
| Designed DNA binding protein | Descriptor: | DBP48, DNA (5'-D(*AP*CP*CP*TP*GP*AP*CP*GP*CP*GP*A)-3'), DNA (5'-D(*TP*TP*CP*GP*CP*GP*TP*CP*AP*GP*GP)-3') | Authors: | Doyle, L, Stoddard, B.L, Glasscock, C.J, McHugh, R.P, Pecoraro, R.J. | Deposit date: | 2023-06-27 | Release date: | 2024-08-28 | Method: | X-RAY DIFFRACTION (2.34 Å) | Cite: | Designed DNA binding protein To Be Published
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4YXX
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4YXY
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4YXZ
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5BYO
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6MGD
| Thermosulfurimonas dismutans KpsC, beta Kdo 2,7 transferase | Descriptor: | Capsular polysaccharide export system protein KpsC | Authors: | Doyle, L, Mallette, E, Kimber, M.S, Whitfield, C. | Deposit date: | 2018-09-13 | Release date: | 2019-03-27 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Biosynthesis of a conserved glycolipid anchor for Gram-negative bacterial capsules. Nat.Chem.Biol., 15, 2019
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6MGB
| Thermosulfurimonas dismutans KpsC, beta Kdo 2,4 transferase | Descriptor: | CHLORIDE ION, CYTIDINE-5'-MONOPHOSPHATE, Capsular polysaccharide export system protein KpsC, ... | Authors: | Doyle, L, Mallette, E, Kimber, M.S, Whitfield, C. | Deposit date: | 2018-09-13 | Release date: | 2019-03-27 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Biosynthesis of a conserved glycolipid anchor for Gram-negative bacterial capsules. Nat.Chem.Biol., 15, 2019
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6MGC
| Escherichia coli KpsC, N-terminal domain | Descriptor: | CHLORIDE ION, CYTIDINE-5'-MONOPHOSPHATE, Capsule polysaccharide export protein KpsC, ... | Authors: | Doyle, L, Mallette, E, Kimber, M.S. | Deposit date: | 2018-09-13 | Release date: | 2019-03-27 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Biosynthesis of a conserved glycolipid anchor for Gram-negative bacterial capsules. Nat.Chem.Biol., 15, 2019
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8FUW
| KpsC D160N Kdo adduct | Descriptor: | 3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid, CHLORIDE ION, CYTIDINE-5'-MONOPHOSPHATE, ... | Authors: | Kimber, M.S, Doyle, L, Whitfield, C. | Deposit date: | 2023-01-18 | Release date: | 2023-03-08 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Mechanism and linkage specificities of the dual retaining beta-Kdo glycosyltransferase modules of KpsC from bacterial capsule biosynthesis. J.Biol.Chem., 299, 2023
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8FUX
| KpsC D160C ternary complex | Descriptor: | 3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid, 3-deoxy-beta-D-manno-oct-2-ulopyranosonic acid, CHLORIDE ION, ... | Authors: | Kimber, M.S, Doyle, L, Whitfield, C. | Deposit date: | 2023-01-18 | Release date: | 2023-03-08 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Mechanism and linkage specificities of the dual retaining beta-Kdo glycosyltransferase modules of KpsC from bacterial capsule biosynthesis. J.Biol.Chem., 299, 2023
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5CW9
| Crystal structure of De novo designed ferredoxin-ferredoxin domain insertion protein | Descriptor: | De novo designed ferredoxin-ferredoxin domain insertion protein | Authors: | DiMaio, F, King, I.C, Gleixner, J, Doyle, L, Stoddard, B, Baker, D. | Deposit date: | 2015-07-28 | Release date: | 2015-09-23 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (3.108 Å) | Cite: | Precise assembly of complex beta sheet topologies from de novo designed building blocks. Elife, 4, 2015
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4YY2
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4YY5
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7T8L
| BrxR from Acinetobacter BREX type I phage restriction system | Descriptor: | 1,2-ETHANEDIOL, BrxR, CHLORIDE ION | Authors: | Doyle, L, Kaiser, B, Stoddard, B. | Deposit date: | 2021-12-16 | Release date: | 2022-05-18 | Last modified: | 2022-06-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Identification and characterization of the WYL BrxR protein and its gene as separable regulatory elements of a BREX phage restriction system. Nucleic Acids Res., 50, 2022
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7T8K
| BrxR from Acinetobacter BREX type I phage restriction system bound to DNA | Descriptor: | 1,2-ETHANEDIOL, BrxR, CHLORIDE ION, ... | Authors: | Doyle, L, Kaiser, B, Stoddard, B. | Deposit date: | 2021-12-16 | Release date: | 2022-05-18 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Identification and characterization of the WYL BrxR protein and its gene as separable regulatory elements of a BREX phage restriction system. Nucleic Acids Res., 50, 2022
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3HOJ
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5IEN
| Structure of CDL2.2, a computationally designed Vitamin-D3 binder | Descriptor: | 3-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANOL, CDL2.2, GLYCEROL | Authors: | Stoddard, B.L, Doyle, L.A. | Deposit date: | 2016-02-25 | Release date: | 2017-03-01 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.089 Å) | Cite: | Unintended specificity of an engineered ligand-binding protein facilitated by unpredicted plasticity of the protein fold. Protein Eng.Des.Sel., 31, 2018
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3B5L
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5D9L
| Rsk2 N-terminal Kinase in Complex with bis-phenol pyrazole | Descriptor: | 4,4'-(1H-pyrazole-3,4-diyl)diphenol, GLYCEROL, Ribosomal protein S6 kinase alpha-3 | Authors: | Appleton, B.A. | Deposit date: | 2015-08-18 | Release date: | 2015-09-02 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Discovery of Potent and Selective RSK Inhibitors as Biological Probes. J.Med.Chem., 58, 2015
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5D9K
| Rsk2 N-terminal Kinase in Complex with BI-D1870 | Descriptor: | (7R)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5H)-one, GLYCEROL, Ribosomal protein S6 kinase alpha-3 | Authors: | Appleton, B.A. | Deposit date: | 2015-08-18 | Release date: | 2015-09-02 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Discovery of Potent and Selective RSK Inhibitors as Biological Probes. J.Med.Chem., 58, 2015
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4J9A
| Engineered Digoxigenin binder DIG10.3 | Descriptor: | DIGOXIGENIN, Engineered Digoxigenin binder protein DIG10.3 | Authors: | Stoddard, B.L, Doyle, L.A. | Deposit date: | 2013-02-15 | Release date: | 2013-06-26 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Computational design of ligand-binding proteins with high affinity and selectivity. Nature, 501, 2013
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4J8T
| Engineered Digoxigenin binder DIG10.2 | Descriptor: | DIGOXIGENIN, Engineered Digoxigenin binder protein DIG10.2 | Authors: | Stoddard, B.L, Doyle, L.A. | Deposit date: | 2013-02-14 | Release date: | 2013-06-26 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Computational design of ligand-binding proteins with high affinity and selectivity. Nature, 501, 2013
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5IF6
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5IER
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5IEP
| Structure of CDL2.3b, a computationally designed Vitamin-D3 binder | Descriptor: | 3-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANOL, CDL2.3b | Authors: | Stoddard, B.L, Doyle, L.A. | Deposit date: | 2016-02-25 | Release date: | 2017-03-01 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.893 Å) | Cite: | Unintended specificity of an engineered ligand-binding protein facilitated by unpredicted plasticity of the protein fold. Protein Eng.Des.Sel., 31, 2018
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