7HAU
 
 | | PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr13098 | | Descriptor: | Heat shock protein HSP 90-alpha, [2-(4-methylpiperazin-1-yl)phenyl]methanol | | Authors: | Huang, L, Wang, W, Zhu, Z, Li, Q, Li, M, Zhou, H, Xu, Q, Wen, W, Wang, Q, Yu, F. | | Deposit date: | 2024-07-10 | | Release date: | 2025-03-26 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Novel starting points for fragment-based drug design against human heat-shock protein 90 identified using crystallographic fragment screening.
Iucrj, 12, 2025
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7HB8
 | | PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr13480 | | Descriptor: | Heat shock protein HSP 90-alpha, N-[(1R,2R,4S)-bicyclo[2.2.1]hept-5-en-2-yl]-N-methylthiophene-2-carboxamide | | Authors: | Huang, L, Wang, W, Zhu, Z, Li, Q, Li, M, Zhou, H, Xu, Q, Wen, W, Wang, Q, Yu, F. | | Deposit date: | 2024-07-10 | | Release date: | 2025-03-26 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Novel starting points for fragment-based drug design against human heat-shock protein 90 identified using crystallographic fragment screening.
Iucrj, 12, 2025
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7HAK
 | | PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with PS-6793 | | Descriptor: | 8-fluoro-2-methylquinolin-4-ol, Heat shock protein HSP 90-alpha | | Authors: | Huang, L, Wang, W, Zhu, Z, Li, Q, Li, M, Zhou, H, Xu, Q, Wen, W, Wang, Q, Yu, F. | | Deposit date: | 2024-07-10 | | Release date: | 2025-03-26 | | Method: | X-RAY DIFFRACTION (1.72 Å) | | Cite: | Novel starting points for fragment-based drug design against human heat-shock protein 90 identified using crystallographic fragment screening.
Iucrj, 12, 2025
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7HAG
 | | PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr14186 | | Descriptor: | (3M)-3-(1H-imidazol-1-yl)benzonitrile, Heat shock protein HSP 90-alpha | | Authors: | Huang, L, Wang, W, Zhu, Z, Li, Q, Li, M, Zhou, H, Xu, Q, Wen, W, Wang, Q, Yu, F. | | Deposit date: | 2024-07-10 | | Release date: | 2025-03-26 | | Method: | X-RAY DIFFRACTION (1.53 Å) | | Cite: | Novel starting points for fragment-based drug design against human heat-shock protein 90 identified using crystallographic fragment screening.
Iucrj, 12, 2025
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7HBC
 | | PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr13229 | | Descriptor: | 2-oxo-2,3-dihydro-1,3-benzoxazole-6-sulfonamide, Heat shock protein HSP 90-alpha | | Authors: | Huang, L, Wang, W, Zhu, Z, Li, Q, Li, M, Zhou, H, Xu, Q, Wen, W, Wang, Q, Yu, F. | | Deposit date: | 2024-07-10 | | Release date: | 2025-03-26 | | Method: | X-RAY DIFFRACTION (1.86 Å) | | Cite: | Novel starting points for fragment-based drug design against human heat-shock protein 90 identified using crystallographic fragment screening.
Iucrj, 12, 2025
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7HBO
 | | PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr13368 | | Descriptor: | Heat shock protein HSP 90-alpha, N-[(1S,2S,4S)-bicyclo[2.2.1]hept-5-en-2-yl]-N'-butyl-N-methylurea | | Authors: | Huang, L, Wang, W, Zhu, Z, Li, Q, Li, M, Zhou, H, Xu, Q, Wen, W, Wang, Q, Yu, F. | | Deposit date: | 2024-07-10 | | Release date: | 2025-03-26 | | Method: | X-RAY DIFFRACTION (2.07 Å) | | Cite: | Novel starting points for fragment-based drug design against human heat-shock protein 90 identified using crystallographic fragment screening.
Iucrj, 12, 2025
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7HC0
 | | PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with 4W-0801 | | Descriptor: | 3-(3-bromothiophen-2-yl)-1H-pyrazole, Heat shock protein HSP 90-alpha | | Authors: | Huang, L, Wang, W, Zhu, Z, Li, Q, Li, M, Zhou, H, Xu, Q, Wen, W, Wang, Q, Yu, F. | | Deposit date: | 2024-07-10 | | Release date: | 2025-03-26 | | Method: | X-RAY DIFFRACTION (1.66 Å) | | Cite: | Novel starting points for fragment-based drug design against human heat-shock protein 90 identified using crystallographic fragment screening.
Iucrj, 12, 2025
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7HAV
 | | PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr12879 | | Descriptor: | 3-amino-5-tert-butylthiophene-2-carboxamide, Heat shock protein HSP 90-alpha | | Authors: | Huang, L, Wang, W, Zhu, Z, Li, Q, Li, M, Zhou, H, Xu, Q, Wen, W, Wang, Q, Yu, F. | | Deposit date: | 2024-07-10 | | Release date: | 2025-03-26 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Novel starting points for fragment-based drug design against human heat-shock protein 90 identified using crystallographic fragment screening.
Iucrj, 12, 2025
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7HB2
 | | PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with FL0184 | | Descriptor: | 2-methoxy-7,7-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one, Heat shock protein HSP 90-alpha | | Authors: | Huang, L, Wang, W, Zhu, Z, Li, Q, Li, M, Zhou, H, Xu, Q, Wen, W, Wang, Q, Yu, F. | | Deposit date: | 2024-07-10 | | Release date: | 2025-03-26 | | Method: | X-RAY DIFFRACTION (1.67 Å) | | Cite: | Novel starting points for fragment-based drug design against human heat-shock protein 90 identified using crystallographic fragment screening.
Iucrj, 12, 2025
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7HAT
 | | PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr12860 | | Descriptor: | (furan-2-yl)(thiomorpholin-4-yl)methanone, Heat shock protein HSP 90-alpha | | Authors: | Huang, L, Wang, W, Zhu, Z, Li, Q, Li, M, Zhou, H, Xu, Q, Wen, W, Wang, Q, Yu, F. | | Deposit date: | 2024-07-10 | | Release date: | 2025-03-26 | | Method: | X-RAY DIFFRACTION (2.04 Å) | | Cite: | Novel starting points for fragment-based drug design against human heat-shock protein 90 identified using crystallographic fragment screening.
Iucrj, 12, 2025
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7HB9
 | | PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr13464 | | Descriptor: | 2,5-dichlorothiophene-3-sulfonamide, Heat shock protein HSP 90-alpha | | Authors: | Huang, L, Wang, W, Zhu, Z, Li, Q, Li, M, Zhou, H, Xu, Q, Wen, W, Wang, Q, Yu, F. | | Deposit date: | 2024-07-10 | | Release date: | 2025-03-26 | | Method: | X-RAY DIFFRACTION (1.89 Å) | | Cite: | Novel starting points for fragment-based drug design against human heat-shock protein 90 identified using crystallographic fragment screening.
Iucrj, 12, 2025
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7HBG
 | | PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr13237 | | Descriptor: | Heat shock protein HSP 90-alpha, N-methyl-1-{4-[(pyridin-2-yl)oxy]phenyl}methanamine | | Authors: | Huang, L, Wang, W, Zhu, Z, Li, Q, Li, M, Zhou, H, Xu, Q, Wen, W, Wang, Q, Yu, F. | | Deposit date: | 2024-07-10 | | Release date: | 2025-03-26 | | Method: | X-RAY DIFFRACTION (1.69 Å) | | Cite: | Novel starting points for fragment-based drug design against human heat-shock protein 90 identified using crystallographic fragment screening.
Iucrj, 12, 2025
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7HBD
 | | PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr12810 | | Descriptor: | Heat shock protein HSP 90-alpha, N-(3-chlorophenyl)-2-cyanoacetamide | | Authors: | Huang, L, Wang, W, Zhu, Z, Li, Q, Li, M, Zhou, H, Xu, Q, Wen, W, Wang, Q, Yu, F. | | Deposit date: | 2024-07-10 | | Release date: | 2025-03-26 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Novel starting points for fragment-based drug design against human heat-shock protein 90 identified using crystallographic fragment screening.
Iucrj, 12, 2025
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7HBB
 | | PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr13430 | | Descriptor: | 3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazole-6-sulfonamide, Heat shock protein HSP 90-alpha | | Authors: | Huang, L, Wang, W, Zhu, Z, Li, Q, Li, M, Zhou, H, Xu, Q, Wen, W, Wang, Q, Yu, F. | | Deposit date: | 2024-07-10 | | Release date: | 2025-03-26 | | Method: | X-RAY DIFFRACTION (1.84 Å) | | Cite: | Novel starting points for fragment-based drug design against human heat-shock protein 90 identified using crystallographic fragment screening.
Iucrj, 12, 2025
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7HBL
 | | PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr12214 | | Descriptor: | 3-chloranyl-4-fluoranyl-benzamide, Heat shock protein HSP 90-alpha | | Authors: | Huang, L, Wang, W, Zhu, Z, Li, Q, Li, M, Zhou, H, Xu, Q, Wen, W, Wang, Q, Yu, F. | | Deposit date: | 2024-07-10 | | Release date: | 2025-03-26 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Novel starting points for fragment-based drug design against human heat-shock protein 90 identified using crystallographic fragment screening.
Iucrj, 12, 2025
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7HAH
 | | PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with PS-5160 | | Descriptor: | Heat shock protein HSP 90-alpha, [4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]methanol | | Authors: | Huang, L, Wang, W, Zhu, Z, Li, Q, Li, M, Zhou, H, Xu, Q, Wen, W, Wang, Q, Yu, F. | | Deposit date: | 2024-07-10 | | Release date: | 2025-03-26 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Novel starting points for fragment-based drug design against human heat-shock protein 90 identified using crystallographic fragment screening.
Iucrj, 12, 2025
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7HBQ
 | | PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with FS-2731 | | Descriptor: | 5-bromo-2-(1H-pyrazol-1-yl)pyrimidine, Heat shock protein HSP 90-alpha | | Authors: | Huang, L, Wang, W, Zhu, Z, Li, Q, Li, M, Zhou, H, Xu, Q, Wen, W, Wang, Q, Yu, F. | | Deposit date: | 2024-07-10 | | Release date: | 2025-03-26 | | Method: | X-RAY DIFFRACTION (2.73 Å) | | Cite: | Novel starting points for fragment-based drug design against human heat-shock protein 90 identified using crystallographic fragment screening.
Iucrj, 12, 2025
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7HBU
 | | PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with CC-0741 | | Descriptor: | 1~{H}-indole-7-carboxylic acid, Heat shock protein HSP 90-alpha | | Authors: | Huang, L, Wang, W, Zhu, Z, Li, Q, Li, M, Zhou, H, Xu, Q, Wen, W, Wang, Q, Yu, F. | | Deposit date: | 2024-07-10 | | Release date: | 2025-03-26 | | Method: | X-RAY DIFFRACTION (1.44 Å) | | Cite: | Novel starting points for fragment-based drug design against human heat-shock protein 90 identified using crystallographic fragment screening.
Iucrj, 12, 2025
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7HAP
 | | PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr13088 | | Descriptor: | Heat shock protein HSP 90-alpha, [1-(4-fluorophenyl)-5-methyl-1H-pyrazol-4-yl]methanol | | Authors: | Huang, L, Wang, W, Zhu, Z, Li, Q, Li, M, Zhou, H, Xu, Q, Wen, W, Wang, Q, Yu, F. | | Deposit date: | 2024-07-10 | | Release date: | 2025-03-26 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Novel starting points for fragment-based drug design against human heat-shock protein 90 identified using crystallographic fragment screening.
Iucrj, 12, 2025
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7HBE
 | | PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr12771 | | Descriptor: | 5-methyl-2-(trifluoromethyl)furan-3-carboxamide, Heat shock protein HSP 90-alpha | | Authors: | Huang, L, Wang, W, Zhu, Z, Li, Q, Li, M, Zhou, H, Xu, Q, Wen, W, Wang, Q, Yu, F. | | Deposit date: | 2024-07-10 | | Release date: | 2025-03-26 | | Method: | X-RAY DIFFRACTION (1.79 Å) | | Cite: | Novel starting points for fragment-based drug design against human heat-shock protein 90 identified using crystallographic fragment screening.
Iucrj, 12, 2025
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7HBV
 | | PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with PS-4833 | | Descriptor: | 7-methoxy-1H-pyrrolo[2,3-c]pyridine, Heat shock protein HSP 90-alpha | | Authors: | Huang, L, Wang, W, Zhu, Z, Li, Q, Li, M, Zhou, H, Xu, Q, Wen, W, Wang, Q, Yu, F. | | Deposit date: | 2024-07-10 | | Release date: | 2025-03-26 | | Method: | X-RAY DIFFRACTION (1.56 Å) | | Cite: | Novel starting points for fragment-based drug design against human heat-shock protein 90 identified using crystallographic fragment screening.
Iucrj, 12, 2025
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7HBW
 | | PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with PS-4774 | | Descriptor: | 3-bromo-1H-pyrazolo[3,4-c]pyridine, Heat shock protein HSP 90-alpha | | Authors: | Huang, L, Wang, W, Zhu, Z, Li, Q, Li, M, Zhou, H, Xu, Q, Wen, W, Wang, Q, Yu, F. | | Deposit date: | 2024-07-10 | | Release date: | 2025-03-26 | | Method: | X-RAY DIFFRACTION (1.91 Å) | | Cite: | Novel starting points for fragment-based drug design against human heat-shock protein 90 identified using crystallographic fragment screening.
Iucrj, 12, 2025
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7HBX
 | | PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with AS-5591 | | Descriptor: | (3-methyl-5-phenyl-1,2-oxazol-4-yl)methanol, Heat shock protein HSP 90-alpha | | Authors: | Huang, L, Wang, W, Zhu, Z, Li, Q, Li, M, Zhou, H, Xu, Q, Wen, W, Wang, Q, Yu, F. | | Deposit date: | 2024-07-10 | | Release date: | 2025-03-26 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Novel starting points for fragment-based drug design against human heat-shock protein 90 identified using crystallographic fragment screening.
Iucrj, 12, 2025
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7HB7
 | | PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr12696 | | Descriptor: | 2,2-dimethyl-2,3-dihydro-1-benzofuran-7-carboxamide, Heat shock protein HSP 90-alpha | | Authors: | Huang, L, Wang, W, Zhu, Z, Li, Q, Li, M, Zhou, H, Xu, Q, Wen, W, Wang, Q, Yu, F. | | Deposit date: | 2024-07-10 | | Release date: | 2025-03-26 | | Method: | X-RAY DIFFRACTION (2.98 Å) | | Cite: | Novel starting points for fragment-based drug design against human heat-shock protein 90 identified using crystallographic fragment screening.
Iucrj, 12, 2025
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6M71
 | | SARS-Cov-2 RNA-dependent RNA polymerase in complex with cofactors | | Descriptor: | Non-structural protein 7, Non-structural protein 8, RNA-directed RNA polymerase | | Authors: | Gao, Y, Yan, L, Huang, Y, Liu, F, Cao, L, Wang, T, Wang, Q, Lou, Z, Rao, Z. | | Deposit date: | 2020-03-16 | | Release date: | 2020-04-01 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structure of the RNA-dependent RNA polymerase from COVID-19 virus.
Science, 368, 2020
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