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Tetracenomycin ARO/CYC mutant R69A
Descriptor:	Multifunctional cyclase-dehydratase-3-O-methyl transferase tcmN
Authors:	Ames, B.D, Tsai, S.C.
Deposit date:	2007-09-26
Release date:	2008-04-22
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Crystal structure and functional analysis of tetracenomycin ARO/CYC: implications for cyclization specificity of aromatic polyketides. Proc.Natl.Acad.Sci.Usa, 105, 2008

Potent and Selective Inhibitors of PI3K-delta: Obtaining Isoform Selectivity from the Affinity Pocket and Tryptophan Shelf
Descriptor:	2-(1-{[2-(5-fluoro-1H-indol-4-yl)-4-(morpholin-4-yl)pyrido[3,2-d]pyrimidin-6-yl]methyl}piperidin-4-yl)propan-2-ol, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Authors:	Murray, J.M.
Deposit date:	2012-05-02
Release date:	2013-04-17
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (2.67 Å)
Cite:	Potent and selective inhibitors of PI3K-delta: obtaining isoform selectivity from the affinity pocket and tryptophan shelf Bioorg.Med.Chem.Lett., 22, 2012

Potent and Selective Inhibitors of PI3K-delta: Obtaining Isoform Selectivity from the Affinity Pocket and Tryptophan Shelf
Descriptor:	2-(1-{[2-(2H-indazol-4-yl)-4-(morpholin-4-yl)pyrido[3,2-d]pyrimidin-6-yl]methyl}piperidin-4-yl)propan-2-ol, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Authors:	Murray, J.M.
Deposit date:	2012-05-02
Release date:	2013-04-17
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (2.803 Å)
Cite:	Potent and selective inhibitors of PI3K-delta: obtaining isoform selectivity from the affinity pocket and tryptophan shelf Bioorg.Med.Chem.Lett., 22, 2012

Potent and Selective Inhibitors of PI3K-delta: Obtaining Isoform Selectivity from the Affinity Pocket and Tryptophan Shelf
Descriptor:	2-(1-{[2-(2-aminopyrimidin-5-yl)-4-(morpholin-4-yl)pyrido[3,2-d]pyrimidin-6-yl]methyl}piperidin-4-yl)propan-2-ol, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Authors:	Murray, J.M.
Deposit date:	2012-05-02
Release date:	2013-04-17
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (2.94 Å)
Cite:	Potent and selective inhibitors of PI3K-delta: obtaining isoform selectivity from the affinity pocket and tryptophan shelf Bioorg.Med.Chem.Lett., 22, 2012