8PI7
 
 | | DNA binding domain of HNF-1A bound to P2-HNF4A promoter DNA variant (P2 -169C>T) | | Descriptor: | CHLORIDE ION, Chains: E, Chains: F, ... | | Authors: | Kind, L, Myllykoski, M, Raasakka, A, Kursula, P. | | Deposit date: | 2023-06-21 | | Release date: | 2024-06-19 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Molecular mechanism of HNF-1A-mediated HNF4A gene regulation and promoter-driven HNF4A-MODY diabetes.
JCI Insight, 9, 2024
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8PI8
 | | DNA binding domain of HNF-1A bound to P2-HNF4A promoter DNA | | Descriptor: | Chains: E, Chains: F, GLYCEROL, ... | | Authors: | Kind, L, Myllykoski, M, Raasakka, A, Kursula, P. | | Deposit date: | 2023-06-21 | | Release date: | 2024-06-19 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Molecular mechanism of HNF-1A-mediated HNF4A gene regulation and promoter-driven HNF4A-MODY diabetes.
JCI Insight, 9, 2024
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9ETL
 | | Mouse CNPase catalytic domain with nanobody 8D | | Descriptor: | 2',3'-cyclic-nucleotide 3'-phosphodiesterase, Chains: D,C | | Authors: | Schroder, M, Markusson, S, Raasakka, A, Opazo, F, Kursula, P. | | Deposit date: | 2024-03-26 | | Release date: | 2024-12-11 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Mouse CNPase catalytic domain with nanobody 8D
To Be Published
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9ETJ
 | | Mouse CNPase catalytic domain with nanobody 10E | | Descriptor: | 2',3'-cyclic-nucleotide 3'-phosphodiesterase, CALCIUM ION, Chains: C,D,F,H | | Authors: | Markusson, S, Raasakka, A, Opazo, F, Kursula, P. | | Deposit date: | 2024-03-26 | | Release date: | 2024-12-11 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Mouse CNPase catalytic domain with nanobody 10E
To Be Published
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9ERT
 | | Mouse CNPase catalytic domain with nano body 5E | | Descriptor: | 2',3'-cyclic-nucleotide 3'-phosphodiesterase, Chains: B, PHOSPHATE ION | | Authors: | Markusson, S, Raasakka, A, Opazo, F, Kursula, P. | | Deposit date: | 2024-03-25 | | Release date: | 2024-12-11 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Mouse CNPase catalytic domain with nano body 5E
To Be Published
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9ERW
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9ERU
 | | Mouse CNPase catalytic domain with nanobody 7E | | Descriptor: | 2',3'-cyclic-nucleotide 3'-phosphodiesterase, Chains: G,C,E,H | | Authors: | Markusson, S, Raasakka, A, Opazo, F, Kursula, P. | | Deposit date: | 2024-03-25 | | Release date: | 2024-12-25 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Mouse CNPase catalytic domain with nanobody 7E
To Be Published
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8QF5
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8QF3
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8QF4
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7NTP
 | | Human myelin P2 mutant V115A | | Descriptor: | Myelin P2 protein, PALMITIC ACID | | Authors: | Uusitalo, M, Ruskamo, S, Kursula, P. | | Deposit date: | 2021-03-10 | | Release date: | 2021-09-01 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Human myelin protein P2: from crystallography to time-lapse membrane imaging and neuropathy-associated variants.
Febs J., 288, 2021
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7NRW
 | | Human myelin protein P2 mutant M114T | | Descriptor: | CHLORIDE ION, MAGNESIUM ION, Myelin P2 protein, ... | | Authors: | Uusitalo, M, Ruskamo, S, Kursula, P. | | Deposit date: | 2021-03-04 | | Release date: | 2021-09-01 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Human myelin protein P2: from crystallography to time-lapse membrane imaging and neuropathy-associated variants.
Febs J., 288, 2021
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7NSR
 | | Myelin protein P2 I50del | | Descriptor: | CHLORIDE ION, MAGNESIUM ION, Myelin P2 protein, ... | | Authors: | Uusitalo, M, Ruskamo, S, Kursula, P. | | Deposit date: | 2021-03-08 | | Release date: | 2021-09-01 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Human myelin protein P2: from crystallography to time-lapse membrane imaging and neuropathy-associated variants.
Febs J., 288, 2021
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7O60
 | | Crystal structure of human myelin protein P2 at room temperature from joint X-ray and neutron refinement. | | Descriptor: | CITRIC ACID, Myelin P2 protein, PALMITIC ACID | | Authors: | Laulumaa, S, Blakeley, M.P, Kursula, P. | | Deposit date: | 2021-04-09 | | Release date: | 2021-09-01 | | Last modified: | 2024-11-13 | | Method: | NEUTRON DIFFRACTION (2 Å), X-RAY DIFFRACTION | | Cite: | Human myelin protein P2: from crystallography to time-lapse membrane imaging and neuropathy-associated variants.
Febs J., 288, 2021
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2VK3
 | | Crystal structure of rat profilin 2a | | Descriptor: | (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, GLYCEROL, PROFILIN-2, ... | | Authors: | Haikarainen, T, Kursula, P. | | Deposit date: | 2007-12-17 | | Release date: | 2009-02-10 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structure, Modifications and Ligand-Binding Properties of Rat Profilin 2A.
Acta Crystallogr.,Sect.D, 65, 2009
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6TU2
 | | Crystal structure of rat annexin A11 | | Descriptor: | Annexin, CALCIUM ION | | Authors: | Raasakka, A, Lillebostad, P, Vedeler, A, Kursula, P. | | Deposit date: | 2020-01-01 | | Release date: | 2020-05-06 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structure of the ALS Mutation Target Annexin A11 Reveals a Stabilising N-Terminal Segment.
Biomolecules, 10, 2020
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2WUT
 | | Crystal structure of human myelin protein P2 in complex with palmitate | | Descriptor: | CHLORIDE ION, GLYCEROL, MYELIN P2 PROTEIN, ... | | Authors: | Majava, V, Nanekar, R, Kursula, P. | | Deposit date: | 2009-10-09 | | Release date: | 2010-05-12 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structural and Functional Characterization of Human Peripheral Nervous System Myelin Protein P2.
Plos One, 5, 2010
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7Z00
 | | Crystal structure of Vibrio alkaline phosphatase in 1.0 M KBr | | Descriptor: | Alkaline phosphatase, BROMIDE ION, MAGNESIUM ION, ... | | Authors: | Markusson, S, Hjorleifsson, J.G, Kursula, P, Asgeirsson, B. | | Deposit date: | 2022-02-21 | | Release date: | 2022-11-02 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural Characterization of Functionally Important Chloride Binding Sites in the Marine Vibrio Alkaline Phosphatase.
Biochemistry, 61, 2022
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7YZZ
 | | Crystal structure of Vibrio alkaline phosphatase in 0.5 M NaCl | | Descriptor: | 1,2-ETHANEDIOL, Alkaline phosphatase, CHLORIDE ION, ... | | Authors: | Markusson, S, Hjorleifsson, J.G, Kursula, P, Asgeirsson, B. | | Deposit date: | 2022-02-21 | | Release date: | 2022-11-02 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.29 Å) | | Cite: | Structural Characterization of Functionally Important Chloride Binding Sites in the Marine Vibrio Alkaline Phosphatase.
Biochemistry, 61, 2022
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7Q6K
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7Q6J
 | | Crystal structure of the human GDAP1 CMT2 mutant-H123R | | Descriptor: | DI(HYDROXYETHYL)ETHER, Ganglioside-induced differentiation-associated protein 1 | | Authors: | Sutinen, A, Kursula, P. | | Deposit date: | 2021-11-08 | | Release date: | 2022-06-08 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural insights into Charcot-Marie-Tooth disease-linked mutations in human GDAP1.
Febs Open Bio, 12, 2022
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7R24
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7R20
 | | Anti-Arc nanobody E5 | | Descriptor: | Anti-Arc nanobody E5, GLYCEROL, SULFATE ION | | Authors: | Markusson, S, Kursula, P. | | Deposit date: | 2022-02-03 | | Release date: | 2022-06-01 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (1.42 Å) | | Cite: | High-affinity anti-Arc nanobodies provide tools for structural and functional studies.
Plos One, 17, 2022
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7R1Z
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7R23
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