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4BYI
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BU of 4byi by Molmil
Aurora A kinase bound to a highly selective imidazopyridine inhibitor
Descriptor: (S)-N-((1-(6-chloro-2-(1,3-dimethyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl)pyrrolidin-3-yl)methyl)acetamide, AURORA KINASE A
Authors:Joshi, A, Kosmopoulou, M, Bayliss, R.
Deposit date:2013-07-19
Release date:2013-11-20
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Aurora Isoform Selectivity: Design and Synthesis of Imidazo[4,5-B]Pyridine Derivatives as Highly Selective Inhibitors of Aurora-A Kinase in Cells.
J.Med.Chem., 56, 2013
4BN1
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BU of 4bn1 by Molmil
Crystal structure of V174M mutant of Aurora-A kinase
Descriptor: ADENOSINE-5'-DIPHOSPHATE, AURORA KINASE A, CALCIUM ION
Authors:Bibby, R.A, Bayliss, R.
Deposit date:2013-05-13
Release date:2014-03-26
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.499 Å)
Cite:Insights Into Aurora-A Kinase Activation Using Unnatural Amino Acids Incorporated by Chemical Modification.
Acs Chem.Biol., 8, 2013
5HNB
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BU of 5hnb by Molmil
CDK8-CYCC IN COMPLEX WITH [6-Hydroxy-3-(3-methyl-benzyl)-1H-indazol-5-yl]-((S)-3-hydroxy-pyrrolidin-1-yl)-methanone
Descriptor: 1,2-ETHANEDIOL, Cyclin-C, Cyclin-dependent kinase 8, ...
Authors:Musil, D, Blagg, J, Schiemann, K.
Deposit date:2016-01-18
Release date:2016-04-27
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:CDK8-CYCC IN COMPLEX WITH [6-Hydroxy-3-(3-methyl-benzyl)-1H-indazol-5-yl]-((S)-3-hydroxy-pyrrolidin-1-yl)-methanone
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