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8PO1
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BU of 8po1 by Molmil
Discovery and Optimisation of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. Compound 22 bound to EGFRinsNPG [V948R]
Descriptor: 2-methyl-5-[[3-[1-[(3~{S},5~{R})-5-methyl-1-propanoyl-pyrrolidin-3-yl]-4-pyridin-4-yl-pyrazol-3-yl]phenoxy]methyl]-3~{H}-isoindol-1-one, Epidermal growth factor receptor, IODIDE ION
Authors:Hargreaves, D.
Deposit date:2023-07-03
Release date:2024-06-05
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations.
J.Med.Chem., 67, 2024
5KBR
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BU of 5kbr by Molmil
Pak1 in complex with 7-azaindole inhibitor
Descriptor: (4-chlorophenyl)-[5-(1-piperidin-4-ylpyrazol-4-yl)-1~{H}-pyrrolo[2,3-b]pyridin-3-yl]methanone, Serine/threonine-protein kinase PAK 1
Authors:Ferguson, A.
Deposit date:2016-06-03
Release date:2016-09-28
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Optimization of Highly Kinase Selective Bis-anilino Pyrimidine PAK1 Inhibitors.
ACS Med Chem Lett, 7, 2016
5KBQ
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BU of 5kbq by Molmil
Pak1 in complex with bis-anilino pyrimidine inhibitor
Descriptor: Serine/threonine-protein kinase PAK 1, [4-methyl-3-[methyl-[2-[(3-methylsulfonyl-5-morpholin-4-yl-phenyl)amino]pyrimidin-4-yl]amino]phenyl]methanol
Authors:Ferguson, A.
Deposit date:2016-06-03
Release date:2016-09-28
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Optimization of Highly Kinase Selective Bis-anilino Pyrimidine PAK1 Inhibitors.
ACS Med Chem Lett, 7, 2016
3L11
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BU of 3l11 by Molmil
Crystal Structure of the Ring Domain of RNF168
Descriptor: E3 ubiquitin-protein ligase RNF168, MALONATE ION, ZINC ION
Authors:Neculai, D, Yermekbayeva, L, Crombet, L, Weigelt, J, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
Deposit date:2009-12-10
Release date:2010-01-19
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Molecular insights into the function of RING finger (RNF)-containing proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent ubiquitylation.
J.Biol.Chem., 287, 2012
2F9J
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BU of 2f9j by Molmil
3.0 angstrom resolution structure of a Y22M mutant of the spliceosomal protein p14 bound to a region of SF3b155
Descriptor: Pre-mRNA branch site protein p14, Splicing factor 3B subunit 1
Authors:Schellenberg, M.J, MacMillan, A.M.
Deposit date:2005-12-06
Release date:2006-01-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of a core spliceosomal protein interface
Proc.Natl.Acad.Sci.Usa, 103, 2006
4DR9
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BU of 4dr9 by Molmil
Crystal structure of a peptide deformylase from synechococcus elongatus in complex with actinonin
Descriptor: ACTINONIN, BROMIDE ION, Peptide deformylase, ...
Authors:Lorimer, D, Abendroth, J, Craig, T, Burgin, A, Segall, A, Rohwler, F.
Deposit date:2012-02-17
Release date:2013-01-16
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure and function of a cyanophage-encoded peptide deformylase.
ISME J, 7, 2013
4DR8
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BU of 4dr8 by Molmil
Crystal structure of a peptide deformylase from Synechococcus elongatus
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, FORMIC ACID, ...
Authors:Lorimer, D, Abendroth, J, Craig, T, Burgin, A, Segall, A, Rohwer, F.
Deposit date:2012-02-17
Release date:2013-03-06
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structure and function of a cyanophage-encoded peptide deformylase.
ISME J, 7, 2013
3MW6
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BU of 3mw6 by Molmil
Crystal structure of NMB1681 from Neisseria meningitidis MC58, a FinO-like RNA chaperone
Descriptor: GLYCEROL, uncharacterized protein NMB1681
Authors:Tan, K, Zhou, M, Duggan, E, Abdullah, J, Joachimiak, A, Midwest Center for Structural Genomics (MCSG)
Deposit date:2010-05-05
Release date:2010-06-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.209 Å)
Cite:N. meningitidis 1681 is a member of the FinO family of RNA chaperones.
Rna Biol., 7, 2010
3UWB
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BU of 3uwb by Molmil
Crystal structure of a probable peptide deformylase from strucynechococcus phage S-SSM7 in complex with actinonin
Descriptor: 1,2-ETHANEDIOL, ACTINONIN, CHLORIDE ION, ...
Authors:Lorimer, D, Abendroth, J, Edwards, T.E, Burgin, A, Segall, A, Rohwer, F.
Deposit date:2011-12-01
Release date:2013-01-09
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure and function of a cyanophage-encoded peptide deformylase.
ISME J, 7, 2013
3UWA
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BU of 3uwa by Molmil
Crystal structure of a probable peptide deformylase from synechococcus phage S-SSM7
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, RIIA-RIIB membrane-associated protein, ZINC ION
Authors:Lorimer, D, Abendroth, J, Edwards, T.E, Burgin, A, Segall, A, Rohwer, F.
Deposit date:2011-12-01
Release date:2013-01-09
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure and function of a cyanophage-encoded peptide deformylase.
ISME J, 7, 2013
4NRG
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BU of 4nrg by Molmil
Crystal Structure of a human Mms2/Ubc13 D118G mutant
Descriptor: Ubiquitin-conjugating enzyme E2 N, Ubiquitin-conjugating enzyme E2 variant 2
Authors:Hodge, C.D, Edwards, R.A, Glover, J.N.M.
Deposit date:2013-11-26
Release date:2014-12-10
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Stochastic gate dynamics regulate the catalytic activity of ubiquitination enzymes.
J.Am.Chem.Soc., 136, 2014
4NR3
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BU of 4nr3 by Molmil
Crystal Structure of a human Mms2/Ubc13 L121G mutant
Descriptor: Ubiquitin-conjugating enzyme E2 N, Ubiquitin-conjugating enzyme E2 variant 2
Authors:Hodge, C.D, Edwards, R.A, Glover, J.N.M.
Deposit date:2013-11-26
Release date:2014-12-10
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.802 Å)
Cite:Stochastic gate dynamics regulate the catalytic activity of ubiquitination enzymes.
J.Am.Chem.Soc., 136, 2014
4NRI
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BU of 4nri by Molmil
Crystal Structure of a human Mms2/Ubc13 A122G mutant
Descriptor: GLYCEROL, Ubiquitin-conjugating enzyme E2 N, Ubiquitin-conjugating enzyme E2 variant 2
Authors:Hodge, C.D, Edwards, R.A, Glover, J.N.M.
Deposit date:2013-11-26
Release date:2014-12-10
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Stochastic gate dynamics regulate the catalytic activity of ubiquitination enzymes.
J.Am.Chem.Soc., 136, 2014
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