6HA8
 
 | | Cryo-EM structure of the ABCF protein VmlR bound to the Bacillus subtilis ribosome | | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | | Authors: | Crowe-McAuliffe, C, Graf, M, Huter, P, Abdelshahid, M, Novacek, J, Wilson, D.N. | | Deposit date: | 2018-08-07 | | Release date: | 2018-08-29 | | Last modified: | 2021-01-27 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structural basis for antibiotic resistance mediated by theBacillus subtilisABCF ATPase VmlR.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6HA1
 | | Cryo-EM structure of a 70S Bacillus subtilis ribosome translating the ErmD leader peptide in complex with telithromycin | | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | Authors: | Crowe-McAuliffe, C, Graf, M, Huter, P, Abdelshahid, M, Novacek, J, Wilson, D.N. | | Deposit date: | 2018-08-07 | | Release date: | 2018-08-29 | | Last modified: | 2021-01-27 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural basis for antibiotic resistance mediated by theBacillus subtilisABCF ATPase VmlR.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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8CEP
 | | Kasugamycin bound to the 30S body | | Descriptor: | (1S,2R,3S,4R,5S,6S)-2,3,4,5,6-PENTAHYDROXYCYCLOHEXYL 2-AMINO-4-{[CARBOXY(IMINO)METHYL]AMINO}-2,3,4,6-TETRADEOXY-ALPHA-D-ARABINO-HEXOPYRANOSIDE, 16S rRNA, 23S rRNA, ... | | Authors: | Paternoga, H, Beckert, B, Wilson, D.N. | | Deposit date: | 2023-02-02 | | Release date: | 2023-07-19 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (2.04 Å) | | Cite: | Structural conservation of antibiotic interaction with ribosomes.
Nat.Struct.Mol.Biol., 30, 2023
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8CGK
 | | Lincomycin and Avilamycin bound to the 50S subunit | | Descriptor: | (2R,3S,4R,6S)-4-hydroxy-6-{[(2R,3aR,4R,4'R,5'S,6S,6'R,7aR)-4'-hydroxy-6-{[(2S,3R,4R,5S,6R)-3-hydroxy-2-{[(2R,3S,4S,5S,6S)-4-hydroxy-6-({(2R,3aS,3a'R,6S,6'R,7R,7'R,7aR,7a'R)-7'-hydroxy-7'-[(1S)-1-hydroxyethyl]-6'-methyl-7-[(2-methylpropanoyl)oxy]octahydro-4H-2,4'-spirobi[[1,3]dioxolo[4,5-c]pyran]-6-yl}oxy)-5-methoxy-2-(methoxymethyl)tetrahydro-2H-pyran-3-yl]oxy}-5-methoxy-6-methyltetrahydro-2H-pyran-4-yl]oxy}-4,6',7a-trimethyloctahydro-4H-spiro[1,3-dioxolo[4,5-c]pyran-2,2'-pyran]-5'-yl]oxy}-2-methyltetrahydro-2H-pyran-3-yl 3,5-dichloro-4-hydroxy-2-methoxy-6-methylbenzoate (non-preferred name), 23S rRNA, 50S ribosomal protein L15, ... | | Authors: | Paternoga, H, Crowe-McAuliffe, C, Beckert, B, Wilson, D.N. | | Deposit date: | 2023-02-05 | | Release date: | 2023-07-19 | | Last modified: | 2023-11-15 | | Method: | ELECTRON MICROSCOPY (1.64 Å) | | Cite: | Structural conservation of antibiotic interaction with ribosomes.
Nat.Struct.Mol.Biol., 30, 2023
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8CGR
 | | Apramycin bound to the 30S body | | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S16, ... | | Authors: | Paternoga, H, Koller, T.O, Beckert, B, Wilson, D.N. | | Deposit date: | 2023-02-06 | | Release date: | 2023-07-26 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (2.12 Å) | | Cite: | Structural conservation of antibiotic interaction with ribosomes.
Nat.Struct.Mol.Biol., 30, 2023
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8CGJ
 | | Streptomycin bound to the 30S body | | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S16, ... | | Authors: | Paternoga, H, Crowe-McAuliffe, C, Beckert, B, Wilson, D.N. | | Deposit date: | 2023-02-05 | | Release date: | 2023-07-26 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (1.79 Å) | | Cite: | Structural conservation of antibiotic interaction with ribosomes.
Nat.Struct.Mol.Biol., 30, 2023
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8CAI
 | | Streptomycin and Hygromycin B bound to the 30S body | | Descriptor: | 16S rRNA, 30S ribosomal protein S16, 30S ribosomal protein S2, ... | | Authors: | Paternoga, H, Crowe-McAuliffe, C, Novacek, J, Wilson, D.N. | | Deposit date: | 2023-01-24 | | Release date: | 2023-07-26 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (2.08 Å) | | Cite: | Structural conservation of antibiotic interaction with ribosomes.
Nat.Struct.Mol.Biol., 30, 2023
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8CGI
 | | Pentacycline TP038 bound to the 30S head | | Descriptor: | 16S rRNA, 30S ribosomal protein S7, Large ribosomal subunit protein bL31A, ... | | Authors: | Paternoga, H, Crowe-McAuliffe, C, Novacek, J, Wilson, D.N. | | Deposit date: | 2023-02-04 | | Release date: | 2023-07-26 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (1.89 Å) | | Cite: | Structural conservation of antibiotic interaction with ribosomes.
Nat.Struct.Mol.Biol., 30, 2023
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8CAZ
 | | empty 30S head | | Descriptor: | 16S rRNA, 30S ribosomal protein S2, 30S ribosomal protein S7, ... | | Authors: | Paternoga, H, Beckert, B, Wilson, D.N. | | Deposit date: | 2023-01-24 | | Release date: | 2023-07-26 | | Last modified: | 2023-09-20 | | Method: | ELECTRON MICROSCOPY (2.11 Å) | | Cite: | Structural conservation of antibiotic interaction with ribosomes.
Nat.Struct.Mol.Biol., 30, 2023
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8CF1
 | | Tetracycline bound to the 30S head | | Descriptor: | 16S rRNA, 30S ribosomal protein S2, 30S ribosomal protein S7, ... | | Authors: | Paternoga, H, Crowe-McAuliffe, C, Beckert, B, Wilson, D.N. | | Deposit date: | 2023-02-02 | | Release date: | 2023-07-26 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (1.82 Å) | | Cite: | Structural conservation of antibiotic interaction with ribosomes.
Nat.Struct.Mol.Biol., 30, 2023
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8CGU
 | | Gentamicin bound to the 30S body | | Descriptor: | (2R,3R,4R,5R)-2-((1S,2S,3R,4S,6R)-4,6-DIAMINO-3-((2R,3R,6S)-3-AMINO-6-(AMINOMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-2-HYDR OXYCYCLOHEXYLOXY)-5-METHYL-4-(METHYLAMINO)-TETRAHYDRO-2H-PYRAN-3,5-DIOL, 16S rRNA, 23S rRNA, ... | | Authors: | Paternoga, H, Crowe-McAuliffe, C, Novacek, J, Wilson, D.N. | | Deposit date: | 2023-02-06 | | Release date: | 2023-07-26 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (1.89 Å) | | Cite: | Structural conservation of antibiotic interaction with ribosomes.
Nat.Struct.Mol.Biol., 30, 2023
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8CGD
 | | Clindamycin bound to the 50S subunit | | Descriptor: | 23S rRNA, 50S ribosomal protein L15, 50S ribosomal protein L25, ... | | Authors: | Paternoga, H, Koller, T.O, Beckert, B, Wilson, D.N. | | Deposit date: | 2023-02-03 | | Release date: | 2023-07-26 | | Last modified: | 2023-11-15 | | Method: | ELECTRON MICROSCOPY (1.98 Å) | | Cite: | Structural conservation of antibiotic interaction with ribosomes.
Nat.Struct.Mol.Biol., 30, 2023
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8CAM
 | | Evernimicin bound to the 50S subunit | | Descriptor: | 23S rRNA, 50S ribosomal protein L15, 50S ribosomal protein L25, ... | | Authors: | Paternoga, H, Crowe-McAuliffe, C, Novacek, J, Wilson, D.N. | | Deposit date: | 2023-01-24 | | Release date: | 2023-07-26 | | Last modified: | 2023-11-15 | | Method: | ELECTRON MICROSCOPY (1.86 Å) | | Cite: | Structural conservation of antibiotic interaction with ribosomes.
Nat.Struct.Mol.Biol., 30, 2023
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8CF8
 | | Eravacycline bound to the 30S head | | Descriptor: | 16S rRNA, 30S ribosomal protein S2, 30S ribosomal protein S7, ... | | Authors: | Paternoga, H, Koller, T.O, Beckert, B, Wilson, D.N. | | Deposit date: | 2023-02-03 | | Release date: | 2023-08-02 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (2.2 Å) | | Cite: | Structural conservation of antibiotic interaction with ribosomes.
Nat.Struct.Mol.Biol., 30, 2023
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8CEU
 | | Retapamulin and Capreomycin bound to the 50S subunit | | Descriptor: | 23S rRNA, 50S ribosomal protein L15, 50S ribosomal protein L25, ... | | Authors: | Paternoga, H, Beckert, B, Wilson, D.N. | | Deposit date: | 2023-02-02 | | Release date: | 2023-07-26 | | Last modified: | 2023-11-15 | | Method: | ELECTRON MICROSCOPY (1.83 Å) | | Cite: | Structural conservation of antibiotic interaction with ribosomes.
Nat.Struct.Mol.Biol., 30, 2023
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8CGV
 | | Tiamulin bound to the 50S subunit | | Descriptor: | 23S rRNA, 50S ribosomal protein L15, 50S ribosomal protein L25, ... | | Authors: | Paternoga, H, Crowe-McAuliffe, C, Novacek, J, Wilson, D.N. | | Deposit date: | 2023-02-06 | | Release date: | 2023-08-02 | | Last modified: | 2023-11-15 | | Method: | ELECTRON MICROSCOPY (1.66 Å) | | Cite: | Structural conservation of antibiotic interaction with ribosomes.
Nat.Struct.Mol.Biol., 30, 2023
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8CA7
 | | Omadacycline and spectinomycin bound to the 30S ribosomal subunit head | | Descriptor: | 16S rRNA, 30S ribosomal protein S7, MAGNESIUM ION, ... | | Authors: | Paternoga, H, Crowe-McAuliffe, C, Wilson, D.N. | | Deposit date: | 2023-01-24 | | Release date: | 2023-08-02 | | Last modified: | 2023-09-20 | | Method: | ELECTRON MICROSCOPY (2.06 Å) | | Cite: | Structural conservation of antibiotic interaction with ribosomes.
Nat.Struct.Mol.Biol., 30, 2023
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8CED
 | | Rnase R bound to a 30S degradation intermediate (State I - head-turning) | | Descriptor: | 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | | Authors: | Paternoga, H, Dimitrova-Paternoga, L, Wilson, D.N. | | Deposit date: | 2023-02-01 | | Release date: | 2023-12-20 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (4.15 Å) | | Cite: | Structural basis of ribosomal 30S subunit degradation by RNase R.
Nature, 626, 2024
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8CEC
 | | Rnase R bound to a 30S degradation intermediate (State I - head-turning) | | Descriptor: | 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | | Authors: | Paternoga, H, Dimitrova-Paternoga, L, Wilson, D.N. | | Deposit date: | 2023-02-01 | | Release date: | 2023-12-20 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.57 Å) | | Cite: | Structural basis of ribosomal 30S subunit degradation by RNase R.
Nature, 626, 2024
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8CDV
 | | Rnase R bound to a 30S degradation intermediate (state II) | | Descriptor: | 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | | Authors: | Paternoga, H, Dimitrova-Paternoga, L, Wilson, D.N. | | Deposit date: | 2023-02-01 | | Release date: | 2023-12-20 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (4.73 Å) | | Cite: | Structural basis of ribosomal 30S subunit degradation by RNase R.
Nature, 626, 2024
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8CEE
 | | Rnase R bound to a 30S degradation intermediate (State I - head-turning) | | Descriptor: | 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | | Authors: | Paternoga, H, Dimitrova-Paternoga, L, Wilson, D.N. | | Deposit date: | 2023-02-01 | | Release date: | 2023-12-20 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Structural basis of ribosomal 30S subunit degradation by RNase R.
Nature, 626, 2024
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8CDU
 | | Rnase R bound to a 30S degradation intermediate (main state) | | Descriptor: | 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | | Authors: | Paternoga, H, Dimitrova-Paternoga, L, Wilson, D.N. | | Deposit date: | 2023-02-01 | | Release date: | 2023-12-20 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural basis of ribosomal 30S subunit degradation by RNase R.
Nature, 626, 2024
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4PSL
 | | Crystal structure of pfuThermo-DBP-RP1 (crystal form I) | | Descriptor: | SULFATE ION, ssDNA binding protein | | Authors: | Gahlei, H, von Moeller, H, Eppers, D, Sohmen, D, Wilson, D.N, Loll, B, Wahl, M.C. | | Deposit date: | 2014-03-07 | | Release date: | 2014-04-30 | | Last modified: | 2014-06-25 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Entrapment of DNA in an intersubunit tunnel system of a single-stranded DNA-binding protein.
Nucleic Acids Res., 42, 2014
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5DOX
 | | Crystal structure of the Thermus thermophilus 70S ribosome in complex with Hygromycin-A at 3.1A resolution | | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | | Authors: | Polikanov, Y.S, Starosta, A.L, Juette, M.F, Altman, R.B, Terry, D.S, Lu, W, Burnett, B.J, Dinos, G, Reynolds, K, Blanchard, S.C, Steitz, T.A, Wilson, D.N. | | Deposit date: | 2015-09-11 | | Release date: | 2015-12-30 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A.
Mol.Cell, 58, 2015
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5DOY
 | | Crystal structure of the Thermus thermophilus 70S ribosome in complex with antibiotic Hygromycin A, mRNA and three tRNAs in the A, P and E sites at 2.6A resolution | | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S10, ... | | Authors: | Polikanov, Y.S, Starosta, A.L, Juette, M.F, Altman, R.B, Terry, D.S, Lu, W, Burnett, B.J, Dinos, G, Reynolds, K, Blanchard, S.C, Steitz, T.A, Wilson, D.N. | | Deposit date: | 2015-09-11 | | Release date: | 2015-12-30 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A.
Mol.Cell, 58, 2015
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