4M25
 
 | | Crystal structure of non-heme iron oxygenase OrfP in complex with Fe and alpha-ketoglutaric acid | | Descriptor: | 2-OXOGLUTARIC ACID, FE (III) ION, L-arginine beta-hydroxylase | | Authors: | Chang, C.Y, Liu, Y.C, Lyu, S.Y, Wu, C.C, Li, T.L. | | Deposit date: | 2013-08-05 | | Release date: | 2014-06-25 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.84 Å) | | Cite: | Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms.
Angew.Chem.Int.Ed.Engl., 53, 2014
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4M73
 | | Mutant structure of methyltransferase from Streptomyces hygroscopicus | | Descriptor: | (2R)-2-hydroxy-3-phenylpropanoic acid, (2R,3R)-2-hydroxy-3-methoxy-3-phenylpropanoic acid, CALCIUM ION, ... | | Authors: | Liu, Y.C, Zou, X.W, Chan, H.C, Huang, C.J, Li, T.L. | | Deposit date: | 2013-08-12 | | Release date: | 2014-06-25 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure and mechanism of a nonhaem-iron SAM-dependent C-methyltransferase and its engineering to a hydratase and an O-methyltransferase
Acta Crystallogr.,Sect.D, 70, 2014
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4MFZ
 | | The crystal structure of acyltransferase in complex with decanoyl-CoA | | Descriptor: | Dbv8 protein, SODIUM ION, SULFATE ION, ... | | Authors: | Lyu, S.Y, Liu, Y.C, Chang, C.Y, Huang, C.J, Li, T.L. | | Deposit date: | 2013-08-28 | | Release date: | 2014-09-03 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Multiple complexes of long aliphatic N-acyltransferases lead to synthesis of 2,6-diacylated/2-acyl-substituted glycopeptide antibiotics, effectively killing vancomycin-resistant enterococcus
J.Am.Chem.Soc., 136, 2014
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4KIB
 | | Crystal structure of methyltransferase from Streptomyces hygroscopicus complexed with S-adenosyl-L-homocysteine and methylphenylpyruvic acid | | Descriptor: | (2R)-2-hydroxy-3-phenylpropanoic acid, (3R)-2-oxo-3-phenylbutanoic acid, CALCIUM ION, ... | | Authors: | Liu, Y.C, Zou, X.W, Chan, H.C, Huang, C.J, Li, T.L. | | Deposit date: | 2013-05-02 | | Release date: | 2014-05-07 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure and mechanism of a nonhaem-iron SAM-dependent C-methyltransferase and its engineering to a hydratase and an O-methyltransferase
Acta Crystallogr.,Sect.D, 70, 2014
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4M2I
 | | Crystal structure of non-heme iron oxygenase OrfP in complex with Fe | | Descriptor: | FE (III) ION, L-arginine beta-hydroxylase | | Authors: | Chang, C.Y, Liu, Y.C, Lyu, S.Y, Wu, C.C, Li, T.L. | | Deposit date: | 2013-08-05 | | Release date: | 2014-06-25 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.53 Å) | | Cite: | Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms.
Angew.Chem.Int.Ed.Engl., 53, 2014
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4M23
 | | Crystal structure of non-heme iron oxygenase OrfP | | Descriptor: | L-arginine beta-hydroxylase | | Authors: | Chang, C.Y, Liu, Y.C, Lyu, S.Y, Wu, C.C, Li, T.L. | | Deposit date: | 2013-08-05 | | Release date: | 2014-06-18 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.76 Å) | | Cite: | Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms.
Angew.Chem.Int.Ed.Engl., 53, 2014
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4M2M
 | | Crystal structure of PLP-dependent cyclase OrfR in complex with PLP-L-Arg | | Descriptor: | ARGININE, Aminotransferase, PYRIDOXAL-5'-PHOSPHATE | | Authors: | Chang, C.Y, Liu, Y.C, Lyu, S.Y, Wu, C.C, Li, T.L. | | Deposit date: | 2013-08-05 | | Release date: | 2014-06-18 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.58 Å) | | Cite: | Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms.
Angew.Chem.Int.Ed.Engl., 53, 2014
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7V4N
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7V4M
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7V4P
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4MFJ
 | | The crystal structure of acyltransferase | | Descriptor: | Putative uncharacterized protein tcp24 | | Authors: | Lyu, S.Y, Liu, Y.C, Chang, C.Y, Huang, C.J, Li, T.L. | | Deposit date: | 2013-08-28 | | Release date: | 2014-09-03 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Multiple complexes of long aliphatic N-acyltransferases lead to synthesis of 2,6-diacylated/2-acyl-substituted glycopeptide antibiotics, effectively killing vancomycin-resistant enterococcus
J.Am.Chem.Soc., 136, 2014
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4MFP
 | | The crystal structure of acyltransferase in complex with decanoyl-CoA and Tei pseudoaglycone | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-amino-2-deoxy-beta-D-glucopyranose, COENZYME A, ... | | Authors: | Lyu, S.Y, Liu, Y.C, Chang, C.Y, Huang, C.J, Li, T.L. | | Deposit date: | 2013-08-28 | | Release date: | 2014-09-03 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Multiple complexes of long aliphatic N-acyltransferases lead to synthesis of 2,6-diacylated/2-acyl-substituted glycopeptide antibiotics, effectively killing vancomycin-resistant enterococcus
J.Am.Chem.Soc., 136, 2014
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4M2E
 | | Crystal structure of non-heme iron oxygenase OrfP in complex with Fe and L-homoarginine | | Descriptor: | FE (III) ION, L-HOMOARGININE, L-arginine beta-hydroxylase | | Authors: | Chang, C.Y, Liu, Y.C, Lyu, S.Y, Wu, C.C, Li, T.L. | | Deposit date: | 2013-08-05 | | Release date: | 2014-06-25 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (2.06 Å) | | Cite: | Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms.
Angew.Chem.Int.Ed.Engl., 53, 2014
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4M2J
 | | Crystal structure of PLP-dependent cyclase OrfR in complex with Au | | Descriptor: | Aminotransferase, GOLD ION, PYRIDOXAL-5'-PHOSPHATE | | Authors: | Chang, C.Y, Liu, Y.C, Lyu, S.Y, Wu, C.C, Li, T.L. | | Deposit date: | 2013-08-05 | | Release date: | 2014-06-18 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.95 Å) | | Cite: | Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms.
Angew.Chem.Int.Ed.Engl., 53, 2014
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4KIC
 | | Crystal structure of methyltransferase from Streptomyces hygroscopicus complexed with S-adenosyl-L-methionine and phenylpyruvic acid | | Descriptor: | (2R)-2-hydroxy-3-phenylpropanoic acid, 3-PHENYLPYRUVIC ACID, CALCIUM ION, ... | | Authors: | Liu, Y.C, Zou, X.W, Chan, H.C, Huang, C.J, Li, T.L. | | Deposit date: | 2013-05-02 | | Release date: | 2014-05-07 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.43 Å) | | Cite: | Structure and mechanism of a nonhaem-iron SAM-dependent C-methyltransferase and its engineering to a hydratase and an O-methyltransferase
Acta Crystallogr.,Sect.D, 70, 2014
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7XX0
 | | C281S glycylthricin complex | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCINE, N-formimidoyl fortimicin A synthase, ... | | Authors: | Wang, Y.L, Li, T.L. | | Deposit date: | 2022-05-27 | | Release date: | 2023-05-31 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.199 Å) | | Cite: | N-Formimidoylation/-iminoacetylation modification in aminoglycosides requires FAD-dependent and ligand-protein NOS bridge dual chemistry.
Nat Commun, 14, 2023
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7XYE
 | | The apo structure of Orf1 | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, N-formimidoyl fortimicin A synthase | | Authors: | Wang, Y.L, Li, T.L. | | Deposit date: | 2022-06-01 | | Release date: | 2023-05-31 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.482 Å) | | Cite: | N-Formimidoylation/-iminoacetylation modification in aminoglycosides requires FAD-dependent and ligand-protein NOS bridge dual chemistry.
Nat Commun, 14, 2023
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7XXD
 | | Orf1-sarcosine complex | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, N-formimidoyl fortimicin A synthase, SARCOSINE | | Authors: | Wang, Y.L, Li, T.L. | | Deposit date: | 2022-05-29 | | Release date: | 2023-05-31 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.982 Å) | | Cite: | N-Formimidoylation/-iminoacetylation modification in aminoglycosides requires FAD-dependent and ligand-protein NOS bridge dual chemistry.
Nat Commun, 14, 2023
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7XXM
 | | Orf1-glycine-4-aminobutylthricin complex | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCINE, N-formimidoyl fortimicin A synthase, ... | | Authors: | Wang, Y.L, Li, T.L. | | Deposit date: | 2022-05-30 | | Release date: | 2023-05-31 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.119 Å) | | Cite: | N-Formimidoylation/-iminoacetylation modification in aminoglycosides requires FAD-dependent and ligand-protein NOS bridge dual chemistry.
Nat Commun, 14, 2023
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4MFK
 | | The crystal structure of acyltransferase in complex with decanoyl-CoA | | Descriptor: | Putative uncharacterized protein tcp24, SULFATE ION, decanoyl-CoA | | Authors: | Lyu, S.Y, Liu, Y.C, Chang, C.Y, Huang, C.J, Li, T.L. | | Deposit date: | 2013-08-28 | | Release date: | 2014-09-03 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Multiple complexes of long aliphatic N-acyltransferases lead to synthesis of 2,6-diacylated/2-acyl-substituted glycopeptide antibiotics, effectively killing vancomycin-resistant enterococcus
J.Am.Chem.Soc., 136, 2014
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4M2C
 | | Crystal structure of non-heme iron oxygenase OrfP in complex with Fe and D-Arg | | Descriptor: | D-ARGININE, FE (III) ION, L-arginine beta-hydroxylase | | Authors: | Chang, C.Y, Liu, Y.C, Lyu, S.Y, Wu, C.C, Li, T.L. | | Deposit date: | 2013-08-05 | | Release date: | 2014-06-25 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms.
Angew.Chem.Int.Ed.Engl., 53, 2014
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4M74
 | | Mutant structure of methyltransferase from Streptomyces hygroscopicus | | Descriptor: | (2R)-2-hydroxy-3-phenylpropanoic acid, (2S,3R)-2,3-dihydroxy-3-phenylpropanoic acid, CALCIUM ION, ... | | Authors: | Liu, Y.C, Zou, X.W, Chan, H.C, Huang, C.J, Li, T.L. | | Deposit date: | 2013-08-12 | | Release date: | 2014-06-25 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structure and mechanism of a nonhaem-iron SAM-dependent C-methyltransferase and its engineering to a hydratase and an O-methyltransferase
Acta Crystallogr.,Sect.D, 70, 2014
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7XXC
 | | Orf1-glycine-glycylthricin complex | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCINE, N-formimidoyl fortimicin A synthase, ... | | Authors: | Wang, Y.L, Li, T.L. | | Deposit date: | 2022-05-29 | | Release date: | 2023-05-31 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.989 Å) | | Cite: | N-Formimidoylation/-iminoacetylation modification in aminoglycosides requires FAD-dependent and ligand-protein NOS bridge dual chemistry.
Nat Commun, 14, 2023
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7XXP
 | | F316A-glycine-streptothricin F complex | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCINE, N-formimidoyl fortimicin A synthase, ... | | Authors: | Wang, Y.L, Li, T.L. | | Deposit date: | 2022-05-30 | | Release date: | 2023-05-31 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.052 Å) | | Cite: | N-Formimidoylation/-iminoacetylation modification in aminoglycosides requires FAD-dependent and ligand-protein NOS bridge dual chemistry.
Nat Commun, 14, 2023
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7XYL
 | | E426Q-glycine-glycylthricin complex | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCINE, N-formimidoyl fortimicin A synthase, ... | | Authors: | Wang, Y.L, Li, T.L. | | Deposit date: | 2022-06-01 | | Release date: | 2023-05-31 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.099 Å) | | Cite: | N-Formimidoylation/-iminoacetylation modification in aminoglycosides requires FAD-dependent and ligand-protein NOS bridge dual chemistry.
Nat Commun, 14, 2023
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