5LEA
| Crystal structure of DARPin-DARPin rigid fusion, variant DD_Off7_12_3G124 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, DD_Off7_12_3G124 | Authors: | Batyuk, A, Wu, Y, Mittl, P.R, Plueckthun, A. | Deposit date: | 2016-06-29 | Release date: | 2017-08-02 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Rigidly connected multispecific artificial binders with adjustable geometries. Sci Rep, 7, 2017
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5LED
| Crystal structure of DARPin-DARPin rigid fusion, variant DDD_D12_12_D12_12_D12 | Descriptor: | DDD_D12_12_D12_12_D12 | Authors: | Batyuk, A, Wu, Y, Mittl, P.R, Plueckthun, A. | Deposit date: | 2016-06-29 | Release date: | 2017-08-02 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Rigidly connected multispecific artificial binders with adjustable geometries. Sci Rep, 7, 2017
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5LEM
| Crystal structure of DARPin-DARPin rigid fusion, variant DD_Off7_11_3G124 in complex with Maltose-binding Protein and Green Fluorescent Protein | Descriptor: | DD_Off7_11_3G124, Green fluorescent protein, Maltose-binding periplasmic protein | Authors: | Batyuk, A, Wu, Y, Mittl, P.R, Plueckthun, A. | Deposit date: | 2016-06-30 | Release date: | 2017-08-02 | Last modified: | 2019-10-16 | Method: | X-RAY DIFFRACTION (2.98 Å) | Cite: | Rigidly connected multispecific artificial binders with adjustable geometries. Sci Rep, 7, 2017
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5LW1
| Crystal structure of DARPin-DARPin rigid fusion, variant DD_232_11_D12 in complex JNK1a1 and JIP1 peptide | Descriptor: | ADENOSINE, C-Jun-amino-terminal kinase-interacting protein 1, DD_232_11_D12, ... | Authors: | Wu, Y, Batyuk, A, Mittl, P.R, Honegger, A, Plueckthun, A. | Deposit date: | 2016-09-15 | Release date: | 2017-12-13 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural Basis for the Selective Inhibition of c-Jun N-Terminal Kinase 1 Determined by Rigid DARPin-DARPin Fusions. J.Mol.Biol., 430, 2018
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5LE6
| Crystal structure of DARPin-DARPin rigid fusion, variant DD_D12_09_D12 | Descriptor: | DD_D12_09_D12, GLYCEROL, SULFATE ION | Authors: | Batyuk, A, Wu, Y, Mittl, P.R, Plueckthun, A. | Deposit date: | 2016-06-29 | Release date: | 2017-08-02 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Rigidly connected multispecific artificial binders with adjustable geometries. Sci Rep, 7, 2017
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8QBC
| Reactive amide intermediate in sperm whale myoglobin mutant H64V V68A | Descriptor: | ACETATE ION, Myoglobin, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Tinzl, M, Mittl, P.R.E, Hilvert, D. | Deposit date: | 2023-08-24 | Release date: | 2023-12-13 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.23 Å) | Cite: | Myoglobin-Catalyzed Azide Reduction Proceeds via an Anionic Metal Amide Intermediate. J.Am.Chem.Soc., 146, 2024
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8QBA
| Sperm whale myoblogin mutant H64V V68A in complex with glycine ethyl ester | Descriptor: | ACETATE ION, Myoglobin, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Tinzl, M, Mittl, P.R.E, Hilvert, D. | Deposit date: | 2023-08-24 | Release date: | 2023-12-13 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.39 Å) | Cite: | Myoglobin-Catalyzed Azide Reduction Proceeds via an Anionic Metal Amide Intermediate. J.Am.Chem.Soc., 146, 2024
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2CJX
| Extended substrate recognition in caspase-3 revealed by high resolution X-ray structure analysis | Descriptor: | CASPASE-3, PHQ-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE | Authors: | Ganesan, R, Mittl, P.R.E, Jelakovic, S, Grutter, M.G. | Deposit date: | 2006-04-09 | Release date: | 2006-06-27 | Last modified: | 2017-06-28 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Extended Substrate Recognition in Caspase-3 Revealed by High Resolution X-Ray Structure Analysis J.Mol.Biol., 359, 2006
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2CJY
| Extended substrate recognition in caspase-3 revealed by high resolution X-ray structure analysis | Descriptor: | CASPASE-3, PHQ-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE | Authors: | Ganesan, R, Mittl, P.R.E, Jelakovic, S, Grutter, M.G. | Deposit date: | 2006-04-09 | Release date: | 2006-06-27 | Last modified: | 2017-06-28 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | Extended Substrate Recognition in Caspase-3 Revealed by High Resolution X-Ray Structure Analysis J.Mol.Biol., 359, 2006
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7QNP
| Designed Armadillo repeat protein N(A4)M4C(AII) co-crystallized with hen egg white lysozyme | Descriptor: | 1,2-ETHANEDIOL, 1,4-DIETHYLENE DIOXIDE, Designed Armadillo Repeat Protein N(A4)M4C(AII), ... | Authors: | Michel, E, Mittl, P.R.E, Plueckthun, A. | Deposit date: | 2021-12-21 | Release date: | 2022-06-08 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.586 Å) | Cite: | Improved Repeat Protein Stability by Combined Consensus and Computational Protein Design. Biochemistry, 62, 2023
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5OD9
| Structure of the engineered metalloesterase MID1sc9 | Descriptor: | (2~{S})-2-phenylpropanoic acid, 1,2-ETHANEDIOL, CHLORIDE ION, ... | Authors: | Studer, S, Mittl, P.R.E, Hilvert, D. | Deposit date: | 2017-07-05 | Release date: | 2018-12-12 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.13 Å) | Cite: | Evolution of a highly active and enantiospecific metalloenzyme from short peptides. Science, 362, 2018
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6QEP
| EngBF DARPin Fusion 4b H14 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, MANGANESE (II) ION, ... | Authors: | Ernst, P, Pluckthun, A, Mittl, P.R.E. | Deposit date: | 2019-01-08 | Release date: | 2019-11-06 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural analysis of biological targets by host:guest crystal lattice engineering. Sci Rep, 9, 2019
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6QFO
| EngBF DARPin Fusion 9b 3G124 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, MANGANESE (II) ION, ... | Authors: | Ernst, P, Pluckthun, A, Mittl, P.R.E. | Deposit date: | 2019-01-10 | Release date: | 2019-11-06 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural analysis of biological targets by host:guest crystal lattice engineering. Sci Rep, 9, 2019
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6QEV
| EngBF DARPin Fusion 4b B6 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, MANGANESE (II) ION, PEGA domain-containing protein,PEGA domain-containing protein,EngBF DARPin fusion B6 complex, ... | Authors: | Ernst, P, Pluckthun, A, Mittl, P.R.E. | Deposit date: | 2019-01-08 | Release date: | 2019-11-06 | Last modified: | 2020-04-22 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural analysis of biological targets by host:guest crystal lattice engineering. Sci Rep, 9, 2019
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6QFK
| EngBF DARPin Fusion 4b G10 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... | Authors: | Ernst, P, Pluckthun, A, Mittl, P.R.E. | Deposit date: | 2019-01-10 | Release date: | 2019-11-06 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural analysis of biological targets by host:guest crystal lattice engineering. Sci Rep, 9, 2019
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6SA7
| DARPin-Armadillo fusion C8long83 | Descriptor: | DARPin-Armadillo fusion C8long83 | Authors: | Ernst, P, Honegger, A, van der Valk, F, Ewald, C, Mittl, P.R.E, Plucktun, A. | Deposit date: | 2019-07-16 | Release date: | 2019-11-20 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Rigid fusions of designed helical repeat binding proteins efficiently protect a binding surface from crystal contacts. Sci Rep, 9, 2019
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6SA8
| ring-like DARPin-Armadillo fusion H83_D01 | Descriptor: | 1,2-ETHANEDIOL, LYS-ARG-LYS-ARG-LYS-ARG-LYS-ARG-LYS-ARG, ring-like DARPin-Armadillo fusion H83_D01 | Authors: | Ernst, P, Honegger, A, van der Valk, F, Ewald, C, Mittl, P.R.E, Plucktun, A. | Deposit date: | 2019-07-16 | Release date: | 2019-11-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Rigid fusions of designed helical repeat binding proteins efficiently protect a binding surface from crystal contacts. Sci Rep, 9, 2019
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6SH9
| EngBF DARPin Fusion 4b D12 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Endo-alpha-N-acetylgalactosaminidase,DARPin 4b D12, ... | Authors: | Ernst, P, Pluckthun, A, Mittl, P.R.E. | Deposit date: | 2019-08-06 | Release date: | 2019-11-06 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural analysis of biological targets by host:guest crystal lattice engineering. Sci Rep, 9, 2019
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6SA6
| DARPin-Armadillo fusion A5 | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, DARPin-Armadillo fusion A5 | Authors: | Ernst, P, Honegger, A, van der Valk, F, Ewald, C, Mittl, P.R.E, Pluckthun, A. | Deposit date: | 2019-07-16 | Release date: | 2019-11-20 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Rigid fusions of designed helical repeat binding proteins efficiently protect a binding surface from crystal contacts. Sci Rep, 9, 2019
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6Z4R
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6Z4T
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7AQH
| Cell wall binding domain of the Staphylococcal phage 2638A endolysin | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ORF007 | Authors: | Dunne, M, Sobieraj, A, Ernst, P, Mittl, P.R.E, Pluckthun, A, Loessner, M.J. | Deposit date: | 2020-10-21 | Release date: | 2020-12-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Cell wall binding domain of the Staphylococcal phage 2638A endolysin To Be Published
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4BS0
| Crystal Structure of Kemp Eliminase HG3.17 E47N,N300D Complexed with Transition State Analog 6-Nitrobenzotriazole | Descriptor: | 6-NITROBENZOTRIAZOLE, KEMP ELIMINASE HG3.17, SULFATE ION | Authors: | Blomberg, R, Kries, H, Pinkas, D.M, Mittl, P.R.E, Gruetter, M.G, Privett, H.K, Mayo, S, Hilvert, D. | Deposit date: | 2013-06-06 | Release date: | 2013-10-16 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.09 Å) | Cite: | Precision is Essential for Efficient Catalysis in an Evolved Kemp Eliminase Nature, 503, 2013
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4CG4
| Crystal structure of the CHS-B30.2 domains of TRIM20 | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-ETHANETHIOL, PYRIN, ... | Authors: | Weinert, C, Morger, D, Djekic, A, Mittl, P.R.E, Gruetter, M.G. | Deposit date: | 2013-11-20 | Release date: | 2015-04-29 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal Structure of Trim20 C-Terminal Coiled-Coil/B30.2 Fragment: Implications for the Recognition of Higher Order Oligomers Sci.Rep., 5, 2015
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4D49
| Crystal structure of computationally designed armadillo repeat proteins for modular peptide recognition. | Descriptor: | ARGININE, ARMADILLO REPEAT PROTEIN ARM00027, POLY ARG DECAPEPTIDE | Authors: | Reichen, C, Forzani, C, Zhou, T, Parmeggiani, F, Fleishman, S.J, Mittl, P.R.E, Madhurantakam, C, Honegger, A, Ewald, C, Zerbe, O, Baker, D, Caflisch, A, Pluckthun, A. | Deposit date: | 2014-10-27 | Release date: | 2016-01-13 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | Computationally Designed Armadillo Repeat Proteins for Modular Peptide Recognition. J.Mol.Biol., 428, 2016
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