3HDA
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![BU of 3hda by Molmil](/molmil-images/mine/3hda) | PrtC methionine mutants: M226A_DESY | Descriptor: | CALCIUM ION, CHLORIDE ION, Secreted protease C, ... | Authors: | Oberholzer, A.E, Bumann, M, Hege, T, Russo, S, Baumann, U. | Deposit date: | 2009-05-07 | Release date: | 2009-06-30 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.131 Å) | Cite: | Metzincin's canonical methionine is responsible for the structural integrity of the zinc-binding site Biol.Chem., 390, 2009
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7NZY
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![BU of 7nzy by Molmil](/molmil-images/mine/7nzy) | Crystal structure of human Casein Kinase I delta in complex with CGS-15943 | Descriptor: | 9-chloranyl-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine, Casein kinase I isoform delta, MALONATE ION, ... | Authors: | Pichlo, C, Baumann, U. | Deposit date: | 2021-03-24 | Release date: | 2022-10-05 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Phenotypic Discovery of Triazolo[1,5- c ]quinazolines as a First-In-Class Bone Morphogenetic Protein Amplifier Chemotype. J.Med.Chem., 65, 2022
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5OKT
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![BU of 5okt by Molmil](/molmil-images/mine/5okt) | Crystal structure of human Casein Kinase I delta in complex with IWP-2 | Descriptor: | ACETATE ION, Casein kinase I isoform delta, GLYCEROL, ... | Authors: | Pichlo, C, Brunstein, E, Baumann, U. | Deposit date: | 2017-07-25 | Release date: | 2018-04-25 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.13 Å) | Cite: | Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) delta / epsilon. J. Med. Chem., 61, 2018
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2BG5
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![BU of 2bg5 by Molmil](/molmil-images/mine/2bg5) | Crystal Structure of the Phosphoenolpyruvate-binding Enzyme I-Domain from the Thermoanaerobacter tengcongensis PEP: Sugar Phosphotransferase System (PTS) | Descriptor: | PHOSPHOENOLPYRUVATE-PROTEIN KINASE | Authors: | Oberholzer, A.E, Bumann, M, Schneider, P, Baechler, C, Siebold, C, Baumann, U, Erni, B. | Deposit date: | 2004-12-17 | Release date: | 2005-02-02 | Last modified: | 2018-03-07 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Crystal Structure of the Phosphoenolpyruvate-Binding Enzyme I-Domain from the Thermoanaerobacter Tengcongensis Pep: Sugar Phosphotransferase System (Pts) J.Mol.Biol., 346, 2005
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2CKI
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![BU of 2cki by Molmil](/molmil-images/mine/2cki) | Structure of Ulilysin, a member of the pappalysin family of metzincin metalloendopeptidases. | Descriptor: | ARGININE, CALCIUM ION, GLYCEROL, ... | Authors: | Tallant, C, Garcia-Castellanos, R, Seco, J, Baumann, U, Gomis-Ruth, F.X. | Deposit date: | 2006-04-19 | Release date: | 2006-05-09 | Last modified: | 2019-05-08 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Molecular Analysis of Ulilysin, the Structural Prototype of a New Family of Metzincin Metalloproteases. J.Biol.Chem., 281, 2006
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2BTD
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![BU of 2btd by Molmil](/molmil-images/mine/2btd) | Crystal structure of DhaL from E. coli | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PTS-DEPENDENT DIHYDROXYACETONE KINASE | Authors: | Oberholzer, A.E, Schneider, P, Bachler, C, Baumann, U, Erni, B. | Deposit date: | 2005-05-27 | Release date: | 2006-06-22 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal Structure of the Nucleotide-Binding Subunit Dhal of the Escherichia Coli Dihydroxyacetone Kinase. J.Mol.Biol., 359, 2006
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2CEA
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![BU of 2cea by Molmil](/molmil-images/mine/2cea) | CELL DIVISION PROTEIN FTSH | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CELL DIVISION PROTEIN FTSH, MAGNESIUM ION, ... | Authors: | Bieniossek, C, Baumann, U. | Deposit date: | 2006-02-03 | Release date: | 2006-02-09 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | The Molecular Architecture of the Metalloprotease Ftsh. Proc.Natl.Acad.Sci.USA, 103, 2006
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2CE7
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![BU of 2ce7 by Molmil](/molmil-images/mine/2ce7) | EDTA treated | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CELL DIVISION PROTEIN FTSH, MAGNESIUM ION, ... | Authors: | Bieniossek, C, Baumann, U. | Deposit date: | 2006-02-03 | Release date: | 2006-02-09 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.44 Å) | Cite: | The Molecular Architecture of the Metalloprotease Ftsh. Proc.Natl.Acad.Sci.USA, 103, 2006
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6R4W
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![BU of 6r4w by Molmil](/molmil-images/mine/6r4w) | |
6R56
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![BU of 6r56 by Molmil](/molmil-images/mine/6r56) | Crystal structure of PPEP-1(K101E/E184K) | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Pro-Pro endopeptidase, ZINC ION | Authors: | Pichlo, C, Baumann, U. | Deposit date: | 2019-03-24 | Release date: | 2019-06-12 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.77 Å) | Cite: | Molecular determinants of the mechanism and substrate specificity ofClostridium difficileproline-proline endopeptidase-1. J.Biol.Chem., 294, 2019
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6R4Z
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![BU of 6r4z by Molmil](/molmil-images/mine/6r4z) | |
6R59
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![BU of 6r59 by Molmil](/molmil-images/mine/6r59) | |
6R4J
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![BU of 6r4j by Molmil](/molmil-images/mine/6r4j) | Crystal structure of human GFAT-1 G451E in complex with UDP-GlcNAc | Descriptor: | GLUCOSE-6-PHOSPHATE, GLUTAMIC ACID, Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1, ... | Authors: | Ruegenberg, S, Horn, M, Pichlo, C, Allmeroth, K, Baumann, U, Denzel, M.S. | Deposit date: | 2019-03-22 | Release date: | 2020-01-15 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.42 Å) | Cite: | Loss of GFAT-1 feedback regulation activates the hexosamine pathway that modulates protein homeostasis. Nat Commun, 11, 2020
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6R5B
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![BU of 6r5b by Molmil](/molmil-images/mine/6r5b) | |
6R54
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![BU of 6r54 by Molmil](/molmil-images/mine/6r54) | Crystal structure of PPEP-1(E184A) | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, NICKEL (II) ION, Pro-Pro endopeptidase, ... | Authors: | Pichlo, C, Baumann, U. | Deposit date: | 2019-03-24 | Release date: | 2019-06-12 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.417 Å) | Cite: | Molecular determinants of the mechanism and substrate specificity ofClostridium difficileproline-proline endopeptidase-1. J.Biol.Chem., 294, 2019
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6R4E
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![BU of 6r4e by Molmil](/molmil-images/mine/6r4e) | Crystal structure of human GFAT-1 in complex with Glucose-6-Phosphate and L-Glu | Descriptor: | GLUCOSE-6-PHOSPHATE, GLUTAMIC ACID, Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 | Authors: | Ruegenberg, S, Horn, M, Pichlo, C, Allmeroth, K, Baumann, U, Denzel, M.S. | Deposit date: | 2019-03-22 | Release date: | 2020-01-15 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.353 Å) | Cite: | Loss of GFAT-1 feedback regulation activates the hexosamine pathway that modulates protein homeostasis. Nat Commun, 11, 2020
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6R4X
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![BU of 6r4x by Molmil](/molmil-images/mine/6r4x) | |
6R55
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![BU of 6r55 by Molmil](/molmil-images/mine/6r55) | Crystal structure of PPEP-1(E184K) | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Pro-Pro endopeptidase, ZINC ION | Authors: | Pichlo, C, Baumann, U. | Deposit date: | 2019-03-24 | Release date: | 2019-06-12 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.401 Å) | Cite: | Molecular determinants of the mechanism and substrate specificity ofClostridium difficileproline-proline endopeptidase-1. J.Biol.Chem., 294, 2019
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6R4I
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![BU of 6r4i by Molmil](/molmil-images/mine/6r4i) | Crystal structure of human GFAT-1 G461E | Descriptor: | GLUCOSE-6-PHOSPHATE, GLUTAMIC ACID, Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 | Authors: | Ruegenberg, S, Horn, M, Pichlo, C, Allmeroth, K, Baumann, U, Denzel, M.S. | Deposit date: | 2019-03-22 | Release date: | 2020-01-15 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.586 Å) | Cite: | Loss of GFAT-1 feedback regulation activates the hexosamine pathway that modulates protein homeostasis. Nat Commun, 11, 2020
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6R53
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![BU of 6r53 by Molmil](/molmil-images/mine/6r53) | Crystal structure of PPEP-1(K101R) | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Pro-Pro endopeptidase, ZINC ION | Authors: | Pichlo, C, Baumann, U. | Deposit date: | 2019-03-24 | Release date: | 2019-06-12 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.798 Å) | Cite: | Molecular determinants of the mechanism and substrate specificity ofClostridium difficileproline-proline endopeptidase-1. J.Biol.Chem., 294, 2019
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6R4H
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![BU of 6r4h by Molmil](/molmil-images/mine/6r4h) | Crystal structure of human GFAT-1 G451E | Descriptor: | GLUCOSE-6-PHOSPHATE, GLUTAMIC ACID, Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 | Authors: | Ruegenberg, S, Horn, M, Pichlo, C, Allmeroth, K, Baumann, U, Denzel, M.S. | Deposit date: | 2019-03-22 | Release date: | 2020-01-15 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.244 Å) | Cite: | Loss of GFAT-1 feedback regulation activates the hexosamine pathway that modulates protein homeostasis. Nat Commun, 11, 2020
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6R52
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![BU of 6r52 by Molmil](/molmil-images/mine/6r52) | Crystal structure of PPEP-1(K101A) | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Pro-Pro endopeptidase, ZINC ION | Authors: | Pichlo, C, Baumann, U. | Deposit date: | 2019-03-24 | Release date: | 2019-06-12 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.022 Å) | Cite: | Molecular determinants of the mechanism and substrate specificity ofClostridium difficileproline-proline endopeptidase-1. J.Biol.Chem., 294, 2019
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6R5A
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![BU of 6r5a by Molmil](/molmil-images/mine/6r5a) | Crystal structure of PPEP-1(W103F) | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Pro-Pro endopeptidase, ZINC ION | Authors: | Pichlo, C, Baumann, U. | Deposit date: | 2019-03-24 | Release date: | 2019-06-12 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.48 Å) | Cite: | Molecular determinants of the mechanism and substrate specificity ofClostridium difficileproline-proline endopeptidase-1. J.Biol.Chem., 294, 2019
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6HG7
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![BU of 6hg7 by Molmil](/molmil-images/mine/6hg7) | Crystal structure of a collagen II fragment containing the binding site of PEDF and COMP, (POG)4-LKG HRG FTG LQG-POG(4) | Descriptor: | Collagen alpha-1(II) chain, SULFATE ION | Authors: | Gebauer, J.M, Koehler, A, Dietmar, H, Gompert, M, Neundorf, I, Zaucke, F, Koch, M, Baumann, U. | Deposit date: | 2018-08-22 | Release date: | 2018-12-05 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1 Å) | Cite: | COMP and TSP-4 interact specifically with the novel GXKGHR motif only found in fibrillar collagens. Sci Rep, 8, 2018
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6R4F
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![BU of 6r4f by Molmil](/molmil-images/mine/6r4f) | Crystal structure of human GFAT-1 in complex with Glucose-6-Phosphate | Descriptor: | GLUCOSE-6-PHOSPHATE, Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 | Authors: | Ruegenberg, S, Horn, M, Pichlo, C, Allmeroth, K, Baumann, U, Denzel, M.S. | Deposit date: | 2019-03-22 | Release date: | 2020-01-15 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.501 Å) | Cite: | Loss of GFAT-1 feedback regulation activates the hexosamine pathway that modulates protein homeostasis. Nat Commun, 11, 2020
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