6ERB
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6EP5
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6EP2
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6ER8
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6FNE
| Structure of human Brag2 (Sec7-PH domains) with the inhibitor Bragsin bound to the PH domain | Descriptor: | (2~{S})-6-methyl-5-nitro-2-(trifluoromethyl)-2,3-dihydrochromen-4-one, IQ motif and SEC7 domain-containing protein 1, NONAETHYLENE GLYCOL | Authors: | Nawrotek, A, Zeghouf, M, Cherfils, J. | Deposit date: | 2018-02-03 | Release date: | 2019-03-13 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.501 Å) | Cite: | PH-domain-binding inhibitors of nucleotide exchange factor BRAG2 disrupt Arf GTPase signaling. Nat.Chem.Biol., 15, 2019
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6H7E
| GEF regulatory domain | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, SULFATE ION, cDNA FLJ56134, ... | Authors: | Ferrandez, Y, Cherfils, J, Peurois, F. | Deposit date: | 2018-07-31 | Release date: | 2020-02-19 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Membranes prime the RapGEF EPAC1 to transduce cAMP signaling. Nat Commun, 14, 2023
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1R8S
| ARF1[DELTA1-17]-GDP IN COMPLEX WITH A SEC7 DOMAIN CARRYING THE MUTATION OF THE CATALYTIC GLUTAMATE TO LYSINE | Descriptor: | ADP-ribosylation factor 1, Arno, BETA-MERCAPTOETHANOL, ... | Authors: | Renault, L, Guibert, B, Cherfils, J. | Deposit date: | 2003-10-28 | Release date: | 2004-01-20 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.46 Å) | Cite: | Structural snapshots of the mechanism and inhibition of a guanine nucleotide exchange factor Nature, 426, 2003
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4D7R
| Crystal structure of a chimeric protein with the Sec7 domain of Rickettsia prowazekii RalF and the capping domain of Legionella pneumophila RalF | Descriptor: | PROLINE/BETAINE TRANSPORTER, RALF | Authors: | Folly-Klan, M, Sancerne, B, Alix, E, Roy, C.R, Cherfils, J, Campanacci, V. | Deposit date: | 2014-11-27 | Release date: | 2015-01-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | On the Use of Legionella/Rickettsia Chimeras to Investigate the Structure and Regulation of Rickettsia Effector Ralf. J.Struct.Biol., 189, 2015
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4D7Q
| Crystal structure of a chimeric protein with the Sec7 domain of Legionella pneumophila RalF and the capping domain of Rickettsia prowazekii RalF | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | Authors: | Folly-Klan, M, Sancerne, B, Alix, E, Roy, C.R, Cherfils, J, Campanacci, V. | Deposit date: | 2014-11-27 | Release date: | 2015-01-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | On the Use of Legionella/Rickettsia Chimeras to Investigate the Structure and Regulation of Rickettsia Effector Ralf. J.Struct.Biol., 189, 2015
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4C7P
| Crystal structure of Legionella pneumophila RalF F255K mutant | Descriptor: | GLYCEROL, RALF | Authors: | Folly-Klan, M, Alix, E, Stalder, D, Ray, P, Duarte, L.V, Delprato, A, Zeghouf, M, Antonny, B, Campanacci, V, Roy, C.R, Cherfils, J. | Deposit date: | 2013-09-24 | Release date: | 2013-12-04 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | A Novel Membrane Sensor Controls the Localization and Arfgef Activity of Bacterial Ralf. Plos Pathog., 9, 2013
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1R8Q
| FULL-LENGTH ARF1-GDP-MG IN COMPLEX WITH BREFELDIN A AND A SEC7 DOMAIN | Descriptor: | 1,6,7,8,9,11A,12,13,14,14A-DECAHYDRO-1,13-DIHYDROXY-6-METHYL-4H-CYCLOPENT[F]OXACYCLOTRIDECIN-4-ONE, ADP-ribosylation factor 1, Arno, ... | Authors: | Renault, L, Guibert, B, Cherfils, J. | Deposit date: | 2003-10-28 | Release date: | 2004-01-20 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Structural snapshots of the mechanism and inhibition of a guanine nucleotide exchange factor Nature, 426, 2003
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6U3G
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6U3E
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