4ADU
| Crystal structure of plasmodial PLP synthase with bound R5P intermediate | Descriptor: | 1,2-ETHANEDIOL, PYRIDOXINE BIOSYNTHETIC ENZYME PDX1 HOMOLOGUE, PUTATIVE, ... | Authors: | Guedez, G, Sinning, I, Tews, I. | Deposit date: | 2012-01-03 | Release date: | 2012-01-25 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.44 Å) | Cite: | Assembly of the Eukaryotic Plp-Synthase Complex from Plasmodium and Activation of the Pdx1 Enzyme. Structure, 20, 2012
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6TKE
| ChiLob 7/4 H2 HC-C224S Kappa LC-C214S F(ab')2 | Descriptor: | ChiLob 7/4 H2 heavy chain C224S, ChiLob 7/4 H2 kappa chain C214S | Authors: | Orr, C.M, Fisher, H, Tews, I. | Deposit date: | 2019-11-28 | Release date: | 2021-06-09 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Hinge disulfides in human IgG2 CD40 antibodies modulate receptor signaling by regulation of conformation and flexibility. Sci Immunol, 7, 2022
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6TKB
| ChiLob 7/4 H2 HC-C224S F(ab')2 | Descriptor: | Chilob 7/4 H2 heavy chain C224S, Chilob 7/4 H2 kappa chain | Authors: | Orr, C.M, Fisher, H, Tews, I. | Deposit date: | 2019-11-28 | Release date: | 2021-06-09 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Hinge disulfides in human IgG2 CD40 antibodies modulate receptor signaling by regulation of conformation and flexibility. Sci Immunol, 7, 2022
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6TKF
| ChiLob 7/4 H2 HC-C225S KappaLC-C214S F(ab')2 | Descriptor: | ChiLob 7/4 H2 Heavy chain C225S, ChiLob 7/4 H2 Kappa light chain C214S | Authors: | Orr, C.M, Fisher, H, Tews, I. | Deposit date: | 2019-11-28 | Release date: | 2021-06-09 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.18 Å) | Cite: | Hinge disulfides in human IgG2 CD40 antibodies modulate receptor signaling by regulation of conformation and flexibility. Sci Immunol, 7, 2022
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6TKD
| ChiLob 7/4 H2 HC-C228S F(ab')2 | Descriptor: | Chilob 7/4 H2 heavy chain C228S, Chilob 7/4 H2 kappa chain | Authors: | Orr, C.M, Fisher, H, Tews, I. | Deposit date: | 2019-11-28 | Release date: | 2021-06-09 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Hinge disulfides in human IgG2 CD40 antibodies modulate receptor signaling by regulation of conformation and flexibility. Sci Immunol, 7, 2022
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6TKC
| ChiLob 7/4 H2 HC-C225S F(ab')2 | Descriptor: | Chilob 7/4 H2 heavy chain C225S, Chilob 7/4 H2 kappa chain | Authors: | Orr, C.M, Fisher, H, Tews, I. | Deposit date: | 2019-11-28 | Release date: | 2021-06-09 | Last modified: | 2022-12-21 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Hinge disulfides in human IgG2 CD40 antibodies modulate receptor signaling by regulation of conformation and flexibility. Sci Immunol, 7, 2022
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3BB3
| Crystal structure of Toc33 from Arabidopsis thaliana in complex with GDP and Mg2+ | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, T7I23.11 protein | Authors: | Koenig, P, Sinning, I, Schleiff, E, Tews, I. | Deposit date: | 2007-11-09 | Release date: | 2008-04-01 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.94 Å) | Cite: | The GTPase cycle of the chloroplast import receptors Toc33/Toc34: implications from monomeric and dimeric structures. Structure, 16, 2008
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3BB4
| Crystal structure of Toc33 from Arabidopsis thaliana in complex with Mg2+ and GMPPNP | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, T7I23.11 protein | Authors: | Koenig, P, Sinning, I, Schleiff, E, Tews, I. | Deposit date: | 2007-11-09 | Release date: | 2008-04-01 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | The GTPase cycle of the chloroplast import receptors Toc33/Toc34: implications from monomeric and dimeric structures. Structure, 16, 2008
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3DEF
| Crystal structure of Toc33 from Arabidopsis thaliana, dimerization deficient mutant R130A | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, T7I23.11 protein | Authors: | Koenig, P, Schleiff, E, Sinning, I, Tews, I. | Deposit date: | 2008-06-10 | Release date: | 2008-06-24 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | On the significance of Toc-GTPase homodimers J.Biol.Chem., 283, 2008
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3FEM
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8OGG
| Crystal structure of FutA after an accumulated dose of 5 kGy | Descriptor: | FE (III) ION, Putative iron ABC transporter, substrate binding protein | Authors: | Bolton, R, Tews, I. | Deposit date: | 2023-03-20 | Release date: | 2023-08-30 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | A redox switch allows binding of Fe(II) and Fe(III) ions in the cyanobacterial iron-binding protein FutA from Prochlorococcus. Proc.Natl.Acad.Sci.USA, 121, 2024
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8OEM
| Crystal structure of FutA bound to Fe(II) | Descriptor: | FE (II) ION, Putative iron ABC transporter, substrate binding protein | Authors: | Bolton, R, Tews, I. | Deposit date: | 2023-03-10 | Release date: | 2023-08-30 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | A redox switch allows binding of Fe(II) and Fe(III) ions in the cyanobacterial iron-binding protein FutA from Prochlorococcus. Proc.Natl.Acad.Sci.USA, 121, 2024
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8OEI
| SFX structure of FutA after an accumulated dose of 350 kGy | Descriptor: | FE (III) ION, Putative iron ABC transporter, substrate binding protein | Authors: | Bolton, R, Tews, I. | Deposit date: | 2023-03-10 | Release date: | 2023-08-30 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | A redox switch allows binding of Fe(II) and Fe(III) ions in the cyanobacterial iron-binding protein FutA from Prochlorococcus. Proc.Natl.Acad.Sci.USA, 121, 2024
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8RK1
| Crystal structure of FutA bound to Fe(III) solved by neutron diffraction | Descriptor: | FE (III) ION, Putative iron ABC transporter, substrate binding protein | Authors: | Bolton, R, Tews, I. | Deposit date: | 2023-12-22 | Release date: | 2024-01-17 | Last modified: | 2024-03-27 | Method: | NEUTRON DIFFRACTION (2.095 Å) | Cite: | A redox switch allows binding of Fe(II) and Fe(III) ions in the cyanobacterial iron-binding protein FutA from Prochlorococcus. Proc.Natl.Acad.Sci.USA, 121, 2024
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8S2X
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8S2V
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8S2U
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8S2W
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2ABW
| Glutaminase subunit of the plasmodial PLP synthase (Vitamin B6 biosynthesis) | Descriptor: | Pdx2 protein, TETRAETHYLENE GLYCOL | Authors: | Gengenbacher, M, Fitzpatrick, T.B, Raschle, T, Flicker, K, Sinning, I, Mueller, S, Macheroux, P, Tews, I, Kappes, B. | Deposit date: | 2005-07-17 | Release date: | 2006-01-10 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.62 Å) | Cite: | Vitamin B6 Biosynthesis by the Malaria Parasite Plasmodium falciparum: Biochemical and structural insights J.Biol.Chem., 281, 2006
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5LNS
| Crystal structure of Arabidopsis thaliana Pdx1-R5P complex | Descriptor: | PHOSPHATE ION, Pyridoxal 5'-phosphate synthase subunit PDX1.3, RIBULOSE-5-PHOSPHATE | Authors: | Rodrigues, M.J, Windeisen, V, Zhang, Y, Guedez, G, Weber, S, Strohmeier, M, Hanes, J.W, Royant, A, Evans, G, Sinning, I, Ealick, S.E, Begley, T.P, Tews, I. | Deposit date: | 2016-08-06 | Release date: | 2017-01-18 | Last modified: | 2017-02-22 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Lysine relay mechanism coordinates intermediate transfer in vitamin B6 biosynthesis. Nat. Chem. Biol., 13, 2017
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5LNU
| Crystal structure of Arabidopsis thaliana Pdx1-I320 complex | Descriptor: | (4~{S})-4-azanyl-5-oxidanyl-pent-1-en-3-one, PHOSPHATE ION, Pyridoxal 5'-phosphate synthase subunit PDX1.3, ... | Authors: | Rodrigues, M.J, Windeisen, V, Zhang, Y, Guedez, G, Weber, S, Strohmeier, M, Hanes, J.W, Royant, A, Evans, G, Sinning, I, Ealick, S.E, Begley, T.P, Tews, I. | Deposit date: | 2016-08-06 | Release date: | 2017-01-18 | Last modified: | 2017-02-22 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Lysine relay mechanism coordinates intermediate transfer in vitamin B6 biosynthesis. Nat. Chem. Biol., 13, 2017
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5LNR
| Crystal structure of Arabidopsis thaliana Pdx1-PLP complex | Descriptor: | GLYCEROL, PYRIDOXAL-5'-PHOSPHATE, Pyridoxal 5'-phosphate synthase subunit PDX1.3 | Authors: | Rodrigues, M.J, Windeisen, V, Zhang, Y, Guedez, G, Weber, S, Strohmeier, M, Hanes, J.W, Royant, A, Evans, G, Sinning, I, Ealick, S.E, Begley, T.P, Tews, I. | Deposit date: | 2016-08-06 | Release date: | 2017-01-18 | Last modified: | 2017-02-22 | Method: | X-RAY DIFFRACTION (1.61 Å) | Cite: | Lysine relay mechanism coordinates intermediate transfer in vitamin B6 biosynthesis. Nat. Chem. Biol., 13, 2017
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5LNW
| Crystal structure of Arabidopsis thaliana Pdx1-I320-G3P complex | Descriptor: | 5-O-phosphono-beta-D-ribofuranose, GLYCEROL, Pyridoxal 5'-phosphate synthase subunit PDX1.3, ... | Authors: | Rodrigues, M.J, Windeisen, V, Zhang, Y, Guedez, G, Weber, S, Strohmeier, M, Hanes, J.W, Royant, A, Evans, G, Sinning, I, Ealick, S.E, Begley, T.P, Tews, I. | Deposit date: | 2016-08-06 | Release date: | 2017-01-18 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Lysine relay mechanism coordinates intermediate transfer in vitamin B6 biosynthesis. Nat. Chem. Biol., 13, 2017
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5LNV
| Crystal structure of Arabidopsis thaliana Pdx1-I320 complex from multiple crystals | Descriptor: | (4~{S})-4-azanyl-5-oxidanyl-pent-1-en-3-one, PHOSPHATE ION, Pyridoxal 5'-phosphate synthase subunit PDX1.3, ... | Authors: | Rodrigues, M.J, Windeisen, V, Zhang, Y, Guedez, G, Weber, S, Strohmeier, M, Hanes, J.W, Royant, A, Evans, G, Sinning, I, Ealick, S.E, Begley, T.P, Tews, I. | Deposit date: | 2016-08-06 | Release date: | 2017-01-18 | Last modified: | 2018-09-19 | Method: | X-RAY DIFFRACTION (2.24 Å) | Cite: | Lysine relay mechanism coordinates intermediate transfer in vitamin B6 biosynthesis. Nat. Chem. Biol., 13, 2017
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5LNT
| Crystal structure of Arabidopsis thaliana Pdx1K166R-preI320 complex | Descriptor: | PHOSPHATE ION, Pyridoxal 5'-phosphate synthase subunit PDX1.1, [(~{E},4~{S})-4-azanyl-3-oxidanylidene-pent-1-enyl] dihydrogen phosphate | Authors: | Rodrigues, M.J, Windeisen, V, Zhang, Y, Guedez, G, Weber, S, Strohmeier, M, Hanes, J.W, Royant, A, Evans, G, Sinning, I, Ealick, S.E, Begley, T.P, Tews, I. | Deposit date: | 2016-08-06 | Release date: | 2017-01-18 | Last modified: | 2017-02-22 | Method: | X-RAY DIFFRACTION (2.32 Å) | Cite: | Lysine relay mechanism coordinates intermediate transfer in vitamin B6 biosynthesis. Nat. Chem. Biol., 13, 2017
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