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Crystal structure of PLK1 in complex with TAK-960
Descriptor:	4-[(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-2-fluoro-5-methoxy-N-(1-methylpiperidin-4-yl)benzamide, ACETATE ION, Serine/threonine-protein kinase PLK1, ...
Authors:	Hosfield, D.J, Skene, R.J.
Deposit date:	2013-02-07
Release date:	2013-05-29
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Discovery of TAK-960: An orally available small molecule inhibitor of polo-like kinase 1 (PLK1). Bioorg.Med.Chem.Lett., 23, 2013

Crystal structure of PLK1 in complex with a pyrimidodiazepinone inhibitor
Descriptor:	4-{[(7R)-9-cyclopentyl-7-ethenyl-7-fluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl]amino}-3-methoxy-N-(4-methylpiperazin-1-yl)benzamide, ACETATE ION, Serine/threonine-protein kinase PLK1, ...
Authors:	Hosfield, D.J, Skene, R.J.
Deposit date:	2013-02-07
Release date:	2013-05-29
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Discovery of TAK-960: An orally available small molecule inhibitor of polo-like kinase 1 (PLK1). Bioorg.Med.Chem.Lett., 23, 2013

Structure-based optimization of 1H-imidazole-2-carboxamides as Axl kinase inhibitors utilizing a Mer mutant surrogate
Descriptor:	N-[2-{4-[(2S)-4-(methylsulfonyl)morpholin-2-yl]-1,3-thiazol-2-yl}-4-(morpholin-4-yl)phenyl]-1H-imidazole-2-carboxamide, Tyrosine-protein kinase Mer
Authors:	Hoffman, I.D, Lawson, J.D.
Deposit date:	2016-09-16
Release date:	2017-01-25
Last modified:	2024-03-06
Method:	X-RAY DIFFRACTION (2.68 Å)
Cite:	Structure-based optimization of 1H-imidazole-2-carboxamides as Axl kinase inhibitors utilizing a Mer mutant surrogate. Bioorg. Med. Chem. Lett., 27, 2017

Structure-based optimization of 1H-imidazole-2-carboxamides as Axl kinase inhibitors utilizing a Mer mutant surrogate
Descriptor:	N-(2-{4-[(2S)-4-(methylsulfonyl)morpholin-2-yl]-1,3-thiazol-2-yl}phenyl)-1H-imidazole-2-carboxamide, Tyrosine-protein kinase Mer
Authors:	Hoffman, I.D, Lawson, J.D.
Deposit date:	2016-09-13
Release date:	2017-01-25
Last modified:	2024-03-06
Method:	X-RAY DIFFRACTION (2.24 Å)
Cite:	Structure-based optimization of 1H-imidazole-2-carboxamides as Axl kinase inhibitors utilizing a Mer mutant surrogate. Bioorg. Med. Chem. Lett., 27, 2017