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Crystal structure of catalytic domain of TACE with 2-(2-Aminothiazol-4-yl)pyrrolidine-Based Tartrate Diamides
Descriptor:	(2R,3R)-2,3-dihydroxy-4-{(2R)-2-[2-(methylamino)-5-(methylsulfonyl)-1,3-thiazol-4-yl]pyrrolidin-1-yl}-4-oxo-N-{(1R)-1-[4-(1H-pyrazol-1-yl)phenyl]ethyl}butanamide, CALCIUM ION, ISOPROPYL ALCOHOL, ...
Authors:	Orth, P.
Deposit date:	2010-07-28
Release date:	2011-04-20
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (1.88 Å)
Cite:	2-(2-Aminothiazol-4-yl)pyrrolidine-based tartrate diamides as potent, selective and orally bioavailable TACE inhibitors. Bioorg.Med.Chem.Lett., 21, 2011

SAR development and discovery of potent indole-based inhibitors of the hepatitis c virus NS5B polymerase
Descriptor:	5-ethyl-1-(2-fluoro-5-nitrobenzyl)-3-(2-oxo-1,2-dihydropyridin-3-yl)-1H-indole-2-carboxylic acid, PHOSPHATE ION, RNA-directed RNA polymerase
Authors:	Lesburg, C.A, Chen, K.X.
Deposit date:	2011-09-26
Release date:	2012-02-01
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (1.6 Å)
Cite:	A Novel Class of Highly Potent Irreversible Hepatitis C Virus NS5B Polymerase Inhibitors. J.Med.Chem., 55, 2012

SAR development and discovery of potent indole-based inhibitors of the hepatitis C virus NS5B polymerase
Descriptor:	N-(cyclopropylsulfonyl)-1-(2,5-difluorobenzyl)-6-fluoro-5-methyl-3-(2-oxo-1,2-dihydropyridin-3-yl)-1H-indole-2-carboxamide, PHOSPHATE ION, RNA-directed RNA polymerase
Authors:	Lesburg, C.A, Chen, K.X.
Deposit date:	2011-09-26
Release date:	2012-02-01
Last modified:	2024-10-16
Method:	X-RAY DIFFRACTION (1.65 Å)
Cite:	Structure-Activity Relationship (SAR) Development and Discovery of Potent Indole-Based Inhibitors of the Hepatitis C Virus (HCV) NS5B Polymerase. J.Med.Chem., 55, 2012