3O64
Crystal structure of catalytic domain of TACE with 2-(2-Aminothiazol-4-yl)pyrrolidine-Based Tartrate Diamides
Summary for 3O64
Entry DOI | 10.2210/pdb3o64/pdb |
Related | 3KMC 3KME 3LGP |
Related PRD ID | PRD_000919 |
Descriptor | TACE, ISOPROPYL ALCOHOL, N-{(2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl}-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide, ... (7 entities in total) |
Functional Keywords | hydrolase, adam proteins, enzyme inhibitors, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P78536 |
Total number of polymer chains | 2 |
Total formula weight | 62587.83 |
Authors | Orth, P. (deposition date: 2010-07-28, release date: 2011-04-20, Last modification date: 2023-09-06) |
Primary citation | Dai, C.,Li, D.,Popovici-Muller, J.,Zhao, L.,Girijavallabhan, V.M.,Rosner, K.E.,Lavey, B.J.,Rizvi, R.,Shankar, B.B.,Wong, M.K.,Guo, Z.,Orth, P.,Strickland, C.O.,Sun, J.,Niu, X.,Chen, S.,Kozlowski, J.A.,Lundell, D.J.,Piwinski, J.J.,Shih, N.Y.,Siddiqui, M.A. 2-(2-Aminothiazol-4-yl)pyrrolidine-based tartrate diamides as potent, selective and orally bioavailable TACE inhibitors. Bioorg.Med.Chem.Lett., 21:3172-3176, 2011 Cited by PubMed: 21458257DOI: 10.1016/j.bmcl.2011.01.002 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.88 Å) |
Structure validation
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