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6SJ7
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BU of 6sj7 by Molmil
Structure of the human DDB1-DDA1-DCAF15 E3 ubiquitin ligase bound to RBM39 and Indisulam
Descriptor: DDB1- and CUL4-associated factor 15, DET1- and DDB1-associated protein 1, DNA damage-binding protein 1, ...
Authors:Srinivas, H.
Deposit date:2019-08-12
Release date:2019-12-18
Last modified:2019-12-25
Method:ELECTRON MICROSCOPY (3.54 Å)
Cite:Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex.
Nat.Chem.Biol., 16, 2020
2JU0
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BU of 2ju0 by Molmil
Structure of Yeast Frequenin bound to PdtIns 4-kinase
Descriptor: CALCIUM ION, Calcium-binding protein NCS-1, Phosphatidylinositol 4-kinase PIK1
Authors:Ames, J.
Deposit date:2007-08-11
Release date:2007-08-28
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Structural insights into activation of phosphatidylinositol 4-kinase (Pik1) by yeast frequenin (Frq1).
J.Biol.Chem., 282, 2007
4GAO
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BU of 4gao by Molmil
DCNL complex with N-terminally acetylated NEDD8 E2 peptide
Descriptor: BROMIDE ION, DCN1-like protein 2, NEDD8-conjugating enzyme Ubc12
Authors:Monda, J.K, Scott, D.C, Miller, D.J, Harper, J.W, Bennett, E.J, Schulman, B.A.
Deposit date:2012-07-25
Release date:2012-11-28
Last modified:2013-01-30
Method:X-RAY DIFFRACTION (3.28 Å)
Cite:Structural Conservation of Distinctive N-terminal Acetylation-Dependent Interactions across a Family of Mammalian NEDD8 Ligation Enzymes.
Structure, 21, 2013
4GBA
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BU of 4gba by Molmil
DCNL complex with N-terminally acetylated NEDD8 E2 peptide
Descriptor: DCN1-like protein 3, NEDD8-conjugating enzyme UBE2F
Authors:Monda, J.K, Scott, D.C, Miller, D.J, Harper, J.W, Bennett, E.J, Schulman, B.A.
Deposit date:2012-07-26
Release date:2012-11-28
Last modified:2013-01-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Conservation of Distinctive N-terminal Acetylation-Dependent Interactions across a Family of Mammalian NEDD8 Ligation Enzymes.
Structure, 21, 2013
4DG6
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BU of 4dg6 by Molmil
Crystal structure of domains 1 and 2 of LRP6
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Low-density lipoprotein receptor-related protein 6, PHOSPHATE ION
Authors:Ceska, T.A, Doyle, C, Slocombe, P.
Deposit date:2012-01-25
Release date:2012-06-13
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Characterization of the interaction of sclerostin with the LRP family of Wnt co-receptors
To be Published
6GL3
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BU of 6gl3 by Molmil
Crystal structure of human Phosphatidylinositol 4-kinase III beta (PI4KIIIbeta) in complex with ligand 44
Descriptor: (3~{S})-4-(6-azanyl-1-methyl-pyrazolo[3,4-d]pyrimidin-4-yl)-~{N}-(4-methoxy-2-methyl-phenyl)-3-methyl-piperazine-1-carboxamide, Phosphatidylinositol 4-kinase beta,Phosphatidylinositol 4-kinase beta
Authors:Lammens, A, Augustin, M, Steinbacher, S, Reuberson, J.
Deposit date:2018-05-22
Release date:2018-08-15
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (2.77 Å)
Cite:Discovery of a Potent, Orally Bioavailable PI4KIII beta Inhibitor (UCB9608) Able To Significantly Prolong Allogeneic Organ Engraftment in Vivo.
J. Med. Chem., 61, 2018
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