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7MVU
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BU of 7mvu by Molmil
Single particle cryo-EM structure of the Chaetomium thermophilum Nup192-Nic96 complex (Nup192 residues 1-1756; Nic96 residues 240-301)
Descriptor: Nucleoporin NIC96, Nucleoporin NUP192
Authors:Petrovic, S, Samanta, D, Perriches, T, Bley, C.J, Thierbach, K, Brown, B, Nie, S, Mobbs, G.W, Stevens, T.A, Liu, X, Tomaleri, G.P, Schaus, L, Hoelz, A.
Deposit date:2021-05-15
Release date:2022-06-15
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.77 Å)
Cite:Architecture of the linker-scaffold in the nuclear pore.
Science, 376, 2022
7MNI
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BU of 7mni by Molmil
Crystal structure of the N-terminal domain of NUP88 in complex with NUP98 C-terminal Autoproteolytic Domain
Descriptor: Nuclear pore complex protein Nup88, Nuclear pore complex protein Nup98
Authors:Bley, C.J, Nie, S, Mobbs, G.W, Petrovic, S, Gres, A.T, Liu, X, Mukherjee, S, Harvey, S, Huber, F.M, Lin, D.H, Brown, B, Tang, A.W, Rundlet, E.J, Correia, A.R, Chen, S, Regmi, S.G, Stevens, T.A, Jette, C.A, Dasso, M, Patke, A, Palazzo, A.F, Kossiakoff, A.A, Hoelz, A.
Deposit date:2021-05-01
Release date:2022-06-15
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Architecture of the cytoplasmic face of the nuclear pore.
Science, 376, 2022
7MNY
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BU of 7mny by Molmil
Crystal Structure of Nup358/RanBP2 Ran-binding domain 3 in complex with Ran-GPPNHP
Descriptor: E3 SUMO-protein ligase RanBP2, GTP-binding nuclear protein Ran, MAGNESIUM ION, ...
Authors:Bley, C.J, Nie, S, Mobbs, G.W, Petrovic, S, Gres, A.T, Liu, X, Mukherjee, S, Harvey, S, Huber, F.M, Lin, D.H, Brown, B, Tang, A.W, Rundlet, E.J, Correia, A.R, Chen, S, Regmi, S.G, Stevens, T.A, Jette, C.A, Dasso, M, Patke, A, Palazzo, A.F, Kossiakoff, A.A, Hoelz, A.
Deposit date:2021-05-01
Release date:2022-06-15
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Architecture of the cytoplasmic face of the nuclear pore.
Science, 376, 2022
7MNU
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BU of 7mnu by Molmil
Crystal Structure of the ZnF7 of Nucleoporin NUP358/RanBP2 in complex with Ran-GDP
Descriptor: E3 SUMO-protein ligase RanBP2, GTP-binding nuclear protein Ran, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Bley, C.J, Nie, S, Mobbs, G.W, Petrovic, S, Gres, A.T, Liu, X, Mukherjee, S, Harvey, S, Huber, F.M, Lin, D.H, Brown, B, Tang, A.W, Rundlet, E.J, Correia, A.R, Chen, S, Regmi, S.G, Stevens, T.A, Jette, C.A, Dasso, M, Patke, A, Palazzo, A.F, Kossiakoff, A.A, Hoelz, A.
Deposit date:2021-05-01
Release date:2022-06-15
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Architecture of the cytoplasmic face of the nuclear pore.
Science, 376, 2022
7MO2
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BU of 7mo2 by Molmil
Crystal Structure of the ZnF2 of Nucleoporin NUP153 in complex with Ran-GDP
Descriptor: GTP-binding nuclear protein Ran, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Bley, C.J, Nie, S, Mobbs, G.W, Petrovic, S, Gres, A.T, Liu, X, Mukherjee, S, Harvey, S, Huber, F.M, Lin, D.H, Brown, B, Tang, A.W, Rundlet, E.J, Correia, A.R, Chen, S, Regmi, S.G, Stevens, T.A, Jette, C.A, Dasso, M, Patke, A, Palazzo, A.F, Kossiakoff, A.A, Hoelz, A.
Deposit date:2021-05-01
Release date:2022-06-15
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Architecture of the cytoplasmic face of the nuclear pore.
Science, 376, 2022
7MVY
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BU of 7mvy by Molmil
Single particle cryo-EM structure of the Chaetomium thermophilum Nup188-Nic96 complex (Nup188 residues 1-1858; Nic96 residues 240-301)
Descriptor: Nucleoporin NIC96, Nucleoporin NUP188
Authors:Petrovic, S, Samanta, D, Perriches, T, Bley, C.J, Thierbach, K, Brown, B, Nie, S, Mobbs, G.W, Stevens, T.A, Liu, X, Tomaleri, G.P, Schaus, L, Hoelz, A.
Deposit date:2021-05-15
Release date:2022-06-15
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (2.39 Å)
Cite:Architecture of the linker-scaffold in the nuclear pore.
Science, 376, 2022
7MNM
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BU of 7mnm by Molmil
Crystal structure of the N-terminal domain of NUP358/RanBP2 (residues 1-752) T585M mutant in complex with Fab fragment
Descriptor: Antibody Fab14 Heavy Chain, Antibody Fab14 Light Chain, E3 SUMO-protein ligase RanBP2
Authors:Bley, C.J, Nie, S, Mobbs, G.W, Petrovic, S, Gres, A.T, Liu, X, Mukherjee, S, Harvey, S, Huber, F.M, Lin, D.H, Brown, B, Tang, A.W, Rundlet, E.J, Correia, A.R, Chen, S, Regmi, S.G, Stevens, T.A, Jette, C.A, Dasso, M, Patke, A, Palazzo, A.F, Kossiakoff, A.A, Hoelz, A.
Deposit date:2021-05-01
Release date:2022-06-15
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (4.7 Å)
Cite:Architecture of the cytoplasmic face of the nuclear pore.
Science, 376, 2022
7MO5
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BU of 7mo5 by Molmil
Crystal Structure of the ZnF4 of Nucleoporin NUP153 in complex with Ran-GDP
Descriptor: GTP-binding nuclear protein Ran, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Bley, C.J, Nie, S, Mobbs, G.W, Petrovic, S, Gres, A.T, Liu, X, Mukherjee, S, Harvey, S, Huber, F.M, Lin, D.H, Brown, B, Tang, A.W, Rundlet, E.J, Correia, A.R, Chen, S, Regmi, S.G, Stevens, T.A, Jette, C.A, Dasso, M, Patke, A, Palazzo, A.F, Kossiakoff, A.A, Hoelz, A.
Deposit date:2021-05-01
Release date:2022-06-15
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Architecture of the cytoplasmic face of the nuclear pore.
Science, 376, 2022
7MNQ
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BU of 7mnq by Molmil
Crystal Structure of the ZnF2 of Nucleoporin NUP358/RanBP2 in complex with Ran-GDP
Descriptor: E3 SUMO-protein ligase RanBP2, GTP-binding nuclear protein Ran, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Bley, C.J, Nie, S, Mobbs, G.W, Petrovic, S, Gres, A.T, Liu, X, Mukherjee, S, Harvey, S, Huber, F.M, Lin, D.H, Brown, B, Tang, A.W, Rundlet, E.J, Correia, A.R, Chen, S, Regmi, S.G, Stevens, T.A, Jette, C.A, Dasso, M, Patke, A, Palazzo, A.F, Kossiakoff, A.A, Hoelz, A.
Deposit date:2021-05-01
Release date:2022-06-15
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Architecture of the cytoplasmic face of the nuclear pore.
Science, 376, 2022
7MW1
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BU of 7mw1 by Molmil
Crystal structure of the Homo sapiens NUP93-NUP53 complex (NUP93 residues 174-819; NUP53 residues 84-150)
Descriptor: Nuclear pore complex protein Nup93, Nucleoporin Nup35
Authors:Petrovic, S, Samanta, D, Perriches, T, Bley, C.J, Thierbach, K, Brown, B, Nie, S, Mobbs, G.W, Stevens, T.A, Liu, X, Tomaleri, G.P, Schaus, L, Hoelz, A.
Deposit date:2021-05-15
Release date:2022-06-15
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Architecture of the linker-scaffold in the nuclear pore.
Science, 376, 2022
7MNT
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BU of 7mnt by Molmil
Crystal Structure of the ZnF5 or ZnF6 of Nucleoporin NUP358/RanBP2 in complex with Ran-GDP
Descriptor: E3 SUMO-protein ligase RanBP2, GTP-binding nuclear protein Ran, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Bley, C.J, Nie, S, Mobbs, G.W, Petrovic, S, Gres, A.T, Liu, X, Mukherjee, S, Harvey, S, Huber, F.M, Lin, D.H, Brown, B, Tang, A.W, Rundlet, E.J, Correia, A.R, Chen, S, Regmi, S.G, Stevens, T.A, Jette, C.A, Dasso, M, Patke, A, Palazzo, A.F, Kossiakoff, A.A, Hoelz, A.
Deposit date:2021-05-01
Release date:2022-06-15
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Architecture of the cytoplasmic face of the nuclear pore.
Science, 376, 2022
7MO3
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BU of 7mo3 by Molmil
Crystal Structure of the ZnF3 of Nucleoporin NUP153 in complex with Ran-GDP, resolution 2.05 Angstrom
Descriptor: GTP-binding nuclear protein Ran, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Bley, C.J, Nie, S, Mobbs, G.W, Petrovic, S, Gres, A.T, Liu, X, Mukherjee, S, Harvey, S, Huber, F.M, Lin, D.H, Brown, B, Tang, A.W, Rundlet, E.J, Correia, A.R, Chen, S, Regmi, S.G, Stevens, T.A, Jette, C.A, Dasso, M, Patke, A, Palazzo, A.F, Kossiakoff, A.A, Hoelz, A.
Deposit date:2021-05-01
Release date:2022-06-15
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Architecture of the cytoplasmic face of the nuclear pore.
Science, 376, 2022
7MW0
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BU of 7mw0 by Molmil
Crystal structure of Homo sapiens NUP93 solenoid (residues 174-819)
Descriptor: 1,2-ETHANEDIOL, Nuclear pore complex protein Nup93
Authors:Petrovic, S, Samanta, D, Perriches, T, Bley, C.J, Thierbach, K, Brown, B, Nie, S, Mobbs, G.W, Stevens, T.A, Liu, X, Tomaleri, G.P, Schaus, L, Hoelz, A.
Deposit date:2021-05-15
Release date:2022-06-15
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Architecture of the linker-scaffold in the nuclear pore.
Science, 376, 2022
5K7K
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BU of 5k7k by Molmil
Design and Optimization of Biaryl Ether Aryl Sulfonamides as Selective Inhibitors of NaV1.7: Discovery of Clinical Candidate PF-05089771
Descriptor: 4-[4-chloranyl-2-(1~{H}-pyrazol-4-yl)phenoxy]-3-cyano-~{N}-(1,3-thiazol-2-yl)benzenesulfonamide, Cytochrome P450 2C9, PROTOPORPHYRIN IX CONTAINING FE
Authors:Swain, N, Chrencik, J.
Deposit date:2016-05-26
Release date:2017-06-07
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of NaV1.7.
J. Med. Chem., 60, 2017
7JUM
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BU of 7jum by Molmil
Pfs230 D1 domain in complex with neutralizing antibody LMIV230-01
Descriptor: Gametocyte surface protein P230, Neutralizing antibody, LMIV230-01 Single-chain Fv
Authors:Tolia, N, Tang, W.K.
Deposit date:2020-08-20
Release date:2021-03-31
Last modified:2021-04-07
Method:X-RAY DIFFRACTION (1.998 Å)
Cite:A human monoclonal antibody blocks malaria transmission and defines a highly conserved neutralizing epitope on gametes.
Nat Commun, 12, 2021
1VSC
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BU of 1vsc by Molmil
VCAM-1
Descriptor: VASCULAR CELL ADHESION MOLECULE-1
Authors:Wang, J, Stehle, T, Osborn, L.
Deposit date:1995-04-27
Release date:1996-06-20
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The crystal structure of an N-terminal two-domain fragment of vascular cell adhesion molecule 1 (VCAM-1): a cyclic peptide based on the domain 1 C-D loop can inhibit VCAM-1-alpha 4 integrin interaction.
Proc.Natl.Acad.Sci.USA, 92, 1995
7MQD
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BU of 7mqd by Molmil
Bartonella henselae NrnC complexed with pAGG. D4 symmetry.
Descriptor: NanoRNase C, RNA (5'-R(P*AP*GP*G)-3')
Authors:Lormand, J.D, Brownfield, B, Fromme, J.C, Sondermann, H.
Deposit date:2021-05-05
Release date:2021-09-15
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.25 Å)
Cite:Structural characterization of NrnC identifies unifying features of dinucleotidases.
Elife, 10, 2021
7MQB
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BU of 7mqb by Molmil
Bartonella henselae NrnC bound to pGG. D4 Symmetry
Descriptor: NanoRNase C, RNA (5'-R(P*GP*G)-3')
Authors:Lormand, J.D, Brownfield, B, Fromme, J.C, Sondermann, H.
Deposit date:2021-05-05
Release date:2021-09-15
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.25 Å)
Cite:Structural characterization of NrnC identifies unifying features of dinucleotidases.
Elife, 10, 2021
7MQC
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BU of 7mqc by Molmil
Bartonella henselae NrnC bound to pGG. C1 reconstruction.
Descriptor: NanoRNase C, RNA (5'-R(P*GP*G)-3')
Authors:Lormand, J.D, Brownfield, B, Fromme, J.C, Sondermann, H.
Deposit date:2021-05-05
Release date:2021-09-15
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.64 Å)
Cite:Structural characterization of NrnC identifies unifying features of dinucleotidases.
Elife, 10, 2021
7MQG
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BU of 7mqg by Molmil
Bartonella henselae NrnC complexed with pAAAGG. C1 reconstruction.
Descriptor: NanoRNase C, RNA (5'-R(P*AP*AP*AP*GP*G)-3')
Authors:Lormand, J.D, Brownfield, B, Fromme, J.C, Sondermann, H.
Deposit date:2021-05-05
Release date:2021-09-15
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.25 Å)
Cite:Structural characterization of NrnC identifies unifying features of dinucleotidases.
Elife, 10, 2021
7MQI
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BU of 7mqi by Molmil
Bartonella henselae NrnC complexed with pAAAGG in the presence of Ca2+. C1 reconstruction.
Descriptor: NanoRNase C, RNA (5'-R(P*AP*AP*AP*GP*G)-3')
Authors:Lormand, J.D, Brownfield, B, Fromme, J.C, Sondermann, H.
Deposit date:2021-05-05
Release date:2021-09-15
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.21 Å)
Cite:Structural characterization of NrnC identifies unifying features of dinucleotidases.
Elife, 10, 2021
7MQH
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BU of 7mqh by Molmil
Bartonella henselae NrnC complexed with pAAAGG in the presence of Ca2+. D4 Symmetry.
Descriptor: NanoRNase C, RNA (5'-R(P*AP*AP*AP*GP*G)-3')
Authors:Lormand, J.D, Brownfield, B, Fromme, J.C, Sondermann, H.
Deposit date:2021-05-05
Release date:2021-09-15
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural characterization of NrnC identifies unifying features of dinucleotidases.
Elife, 10, 2021
7MQF
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BU of 7mqf by Molmil
Bartonella henselae NrnC complexed with pAAAGG. D4 symmetry.
Descriptor: NanoRNase C, RNA (5'-R(P*AP*AP*AP*GP*G)-3')
Authors:Lormand, J.D, Brownfield, B, Fromme, J.C, Sondermann, H.
Deposit date:2021-05-05
Release date:2021-09-15
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (2.88 Å)
Cite:Structural characterization of NrnC identifies unifying features of dinucleotidases.
Elife, 10, 2021
7MQE
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BU of 7mqe by Molmil
Bartonella henselae NrnC complexed with pAGG. C1 reconstruction.
Descriptor: NanoRNase C, RNA (5'-R(P*AP*GP*G)-3')
Authors:Lormand, J.D, Brownfield, B, Fromme, J.C, Sondermann, H.
Deposit date:2021-05-05
Release date:2021-09-15
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.69 Å)
Cite:Structural characterization of NrnC identifies unifying features of dinucleotidases.
Elife, 10, 2021
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