8ZX5
 
 | AM251-bound GPR55 in complex with G13 | Descriptor: | 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-~{N}-piperidin-1-yl-pyrazole-3-carboxamide, G-protein coupled receptor 55, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | He, Y, Xia, R. | Deposit date: | 2024-06-13 | Release date: | 2024-11-13 | Last modified: | 2025-01-22 | Method: | ELECTRON MICROSCOPY (3.03 Å) | Cite: | Structural insight into GPR55 ligand recognition and G-protein coupling. Cell Res., 35, 2025
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8ZX4
 
 | LPI-bound GPR55 in complex with G13 | Descriptor: | G-protein coupled receptor 55, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | He, Y, Xia, R. | Deposit date: | 2024-06-13 | Release date: | 2024-11-13 | Last modified: | 2025-01-22 | Method: | ELECTRON MICROSCOPY (2.85 Å) | Cite: | Structural insight into GPR55 ligand recognition and G-protein coupling. Cell Res., 35, 2025
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7DW9
 
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7F8Y
 
 | Crystal structure of the cholecystokinin receptor CCKAR in complex with devazepide | Descriptor: | N-[(3S)-1-methyl-2-oxidanylidene-5-phenyl-3H-1,4-benzodiazepin-3-yl]-1H-indole-2-carboxamide, fusion protein of Cholecystokinin receptor type A and Endolysin | Authors: | Zhang, X, He, C, Wang, M, Zhou, Q, Yang, D, Zhu, Y, Wu, B, Zhao, Q. | Deposit date: | 2021-07-02 | Release date: | 2021-10-13 | Last modified: | 2024-11-06 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structures of the human cholecystokinin receptors bound to agonists and antagonists. Nat.Chem.Biol., 17, 2021
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7F8U
 
 | Crystal structure of the cholecystokinin receptor CCKAR in complex with lintitript | Descriptor: | 2-[2-[[4-(2-chlorophenyl)-1,3-thiazol-2-yl]carbamoyl]indol-1-yl]ethanoic acid, Fusion protein of Cholecystokinin receptor type A and Endolysin | Authors: | Zhang, X, He, C, Wang, M, Zhou, Q, Yang, D, Zhu, Y, Wu, B, Zhao, Q. | Deposit date: | 2021-07-02 | Release date: | 2021-10-13 | Last modified: | 2024-11-06 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structures of the human cholecystokinin receptors bound to agonists and antagonists. Nat.Chem.Biol., 17, 2021
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7F8V
 
 | Cryo-EM structure of the cholecystokinin receptor CCKBR in complex with gastrin-17 and Gi | Descriptor: | Gastrin-17, Gastrin/cholecystokinin type B receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Zhang, X, He, C, Wang, M, Zhou, Q, Yang, D, Zhu, Y, Wu, B, Zhao, Q. | Deposit date: | 2021-07-02 | Release date: | 2021-10-13 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structures of the human cholecystokinin receptors bound to agonists and antagonists. Nat.Chem.Biol., 17, 2021
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7F8W
 
 | Cryo-EM structure of the cholecystokinin receptor CCKBR in complex with gastrin-17 and Gq | Descriptor: | Gastrin-17, Gastrin/cholecystokinin type B receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Zhang, X, He, C, Wang, M, Zhou, Q, Yang, D, Zhu, Y, Wu, B, Zhao, Q. | Deposit date: | 2021-07-02 | Release date: | 2021-10-13 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structures of the human cholecystokinin receptors bound to agonists and antagonists. Nat.Chem.Biol., 17, 2021
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7F2O
 
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7F8X
 
 | Crystal structure of the cholecystokinin receptor CCKAR in complex with NN9056 | Descriptor: | ASP-SMF-NLE-GLY-TRP-NLE-OEM-MEA-NH2 (NN9056), Cholecystokinin receptor type A,Endolysin | Authors: | Zhang, X, He, C, Wang, M, Zhou, Q, Yang, D, Zhu, Y, Wu, B, Zhao, Q. | Deposit date: | 2021-07-02 | Release date: | 2021-12-29 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structures of the human cholecystokinin receptors bound to agonists and antagonists. Nat.Chem.Biol., 17, 2021
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1A6R
 
 | GAL6 (YEAST BLEOMYCIN HYDROLASE) MUTANT C73A | Descriptor: | GAL6, SULFATE ION | Authors: | Joshua-Tor, L, Zheng, W, Johnston, S.A. | Deposit date: | 1998-02-27 | Release date: | 1998-10-21 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | The unusual active site of Gal6/bleomycin hydrolase can act as a carboxypeptidase, aminopeptidase, and peptide ligase. Cell(Cambridge,Mass.), 93, 1998
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3SP8
 
 | Crystal structure of NK2 in complex with fractionated Heparin DP10 | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... | Authors: | Recacha, R, Mulloy, B, Gherardi, E. | Deposit date: | 2011-07-01 | Release date: | 2012-07-04 | Last modified: | 2024-11-27 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Crystal structure of NK2 in complex with fractionated Heparin DP10 TO BE PUBLISHED
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7CZ5
 
 | Cryo-EM structure of the human growth hormone-releasing hormone receptor-Gs protein complex | Descriptor: | CHOLESTEROL, Growth hormone-releasing hormone receptor,growth hormone-releasing hormone receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Zhou, F, Zhang, H, Cong, Z, Zhao, L, Zhou, Q, Mao, C, Cheng, X, Shen, D, Cai, X, Ma, C, Wang, Y, Dai, A, Zhou, Y, Sun, W, Zhao, F, Zhao, S, Jiang, H, Jiang, Y, Yang, D, Xu, H.E, Zhang, Y, Wang, M. | Deposit date: | 2020-09-07 | Release date: | 2020-11-18 | Last modified: | 2025-06-25 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structural basis for activation of the growth hormone-releasing hormone receptor. Nat Commun, 11, 2020
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3CDP
 
 | Crystal structure of PPAR-gamma LBD complexed with a partial agonist, analogue of clofibric acid | Descriptor: | (2S)-2-(4-chlorophenoxy)-3-phenylpropanoic acid, Peroxisome proliferator-activated receptor gamma | Authors: | Pochetti, G, Montanari, R, Mazza, F. | Deposit date: | 2008-02-27 | Release date: | 2009-01-13 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Synthesis, biological evaluation and molecular investigation of fluorinated peroxisome proliferator-activated receptors alpha/gamma dual agonists Bioorg.Med.Chem., 20, 2012
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3CDS
 
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3D6D
 
 | Crystal Structure of the complex between PPARgamma LBD and the LT175(R-enantiomer) | Descriptor: | (2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid, Peroxisome proliferator-activated receptor gamma | Authors: | Pochetti, G, Montanari, R. | Deposit date: | 2008-05-19 | Release date: | 2008-12-30 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal Structure of the Peroxisome Proliferator-Activated Receptor gamma (PPARgamma) Ligand Binding Domain Complexed with a Novel Partial Agonist: A New Region of the Hydrophobic Pocket Could Be Exploited for Drug Design J.Med.Chem., 51, 2008
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3GCB
 
 | GAL6 (YEAST BLEOMYCIN HYDROLASE) MUTANT C73A/DELTAK454 | Descriptor: | GAL6, GLYCEROL, SULFATE ION | Authors: | Joshua-Tor, L, Zheng, W, Johnston, S.A. | Deposit date: | 1998-02-27 | Release date: | 1998-10-21 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | The unusual active site of Gal6/bleomycin hydrolase can act as a carboxypeptidase, aminopeptidase, and peptide ligase. Cell(Cambridge,Mass.), 93, 1998
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9IV2
 
 | Identification, structure and agonist design of an androgen membrane receptor. | Descriptor: | 5-ALPHA-DIHYDROTESTOSTERONE, Adhesion G-protein coupled receptor D1, Gs protein alpha subunit, ... | Authors: | Ping, Y.Q, Yang, Z. | Deposit date: | 2024-07-22 | Release date: | 2025-02-12 | Last modified: | 2025-07-02 | Method: | ELECTRON MICROSCOPY (3.53 Å) | Cite: | Identification, structure, and agonist design of an androgen membrane receptor. Cell, 188, 2025
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9IV1
 
 | Identification, structure and agonist design of an androgen membrane receptor. | Descriptor: | 5-ALPHA-DIHYDROTESTOSTERONE, Adhesion G-protein coupled receptor D1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Ping, Y.Q, Yang, Z. | Deposit date: | 2024-07-22 | Release date: | 2025-02-12 | Last modified: | 2025-06-25 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | Identification, structure, and agonist design of an androgen membrane receptor. Cell, 188, 2025
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7C8U
 
 | The crystal structure of COVID-19 main protease in complex with GC376 | Descriptor: | (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase | Authors: | Luan, X, Shang, W, Wang, Y, Yin, W, Jiang, Y, Feng, S, Wang, Y, Liu, M, Zhou, R, Zhang, Z, Wang, F, Cheng, W, Gao, M, Wang, H, Wu, W, Tian, R, Tian, Z, Jin, Y, Jiang, H.W, Zhang, L, Xu, H.E, Zhang, S. | Deposit date: | 2020-06-03 | Release date: | 2020-06-24 | Last modified: | 2024-11-06 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | The crystal structure of COVID-19 main protease in complex with GC376 To Be Published
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8X9S
 
 | Identification, structure and agonist design of an androgen membrane receptor. | Descriptor: | 5-ALPHA-DIHYDROTESTOSTERONE, Adhesion G-protein coupled receptor D1, Gs protein alpha subunit, ... | Authors: | Ping, Y.Q, Yang, Z. | Deposit date: | 2023-12-01 | Release date: | 2025-02-12 | Last modified: | 2025-04-09 | Method: | ELECTRON MICROSCOPY (3.49 Å) | Cite: | Identification, structure, and agonist design of an androgen membrane receptor. Cell, 188, 2025
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8X9T
 
 | Identification, structure and agonist design of an androgen membrane receptor | Descriptor: | Adhesion G-protein coupled receptor D1, Gs protein alpha subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Ping, Y.Q, Yang, Z. | Deposit date: | 2023-12-01 | Release date: | 2025-02-12 | Last modified: | 2025-06-25 | Method: | ELECTRON MICROSCOPY (2.75 Å) | Cite: | Identification, structure, and agonist design of an androgen membrane receptor. Cell, 188, 2025
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8X9U
 
 | Identification, structure and agonist design of an androgen membrane receptor | Descriptor: | (5S,8R,9S,10S,13S,14S,17S)-17-hydroxy-1,10,13-trimethyl-4,5,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one, Adhesion G-protein coupled receptor D1, Gs protein alpha subunit, ... | Authors: | Ping, Y.Q, Yang, Z. | Deposit date: | 2023-12-01 | Release date: | 2025-02-12 | Last modified: | 2025-04-09 | Method: | ELECTRON MICROSCOPY (2.88 Å) | Cite: | Identification, structure, and agonist design of an androgen membrane receptor. Cell, 188, 2025
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