7OTW
DNA-PKcs in complex with AZD7648
Summary for 7OTW
| Entry DOI | 10.2210/pdb7otw/pdb |
| EMDB information | 13068 |
| Descriptor | DNA-dependent protein kinase catalytic subunit,DNA-PKcs, 7-methyl-2-[(7-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(oxan-4-yl)purin-8-one (2 entities in total) |
| Functional Keywords | complex, inhibitor, dna repair, dna binding protein |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 1 |
| Total formula weight | 471755.81 |
| Authors | Liang, S.,Thomas, S.E.,Blundell, T.L. (deposition date: 2021-06-10, release date: 2022-01-12, Last modification date: 2022-02-09) |
| Primary citation | Liang, S.,Thomas, S.E.,Chaplin, A.K.,Hardwick, S.W.,Chirgadze, D.Y.,Blundell, T.L. Structural insights into inhibitor regulation of the DNA repair protein DNA-PKcs. Nature, 601:643-648, 2022 Cited by PubMed: 34987222DOI: 10.1038/s41586-021-04274-9 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (2.99 Å) |
Structure validation
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