6OS0
Structure of synthetic nanobody-stabilized angiotensin II type 1 receptor bound to angiotensin II
Summary for 6OS0
Entry DOI | 10.2210/pdb6os0/pdb |
Descriptor | Type-1 angiotensin II receptor,Soluble cytochrome b562 BRIL fusion protein, Nanobody Nb.AT110i1, Angiotensinogen, ... (6 entities in total) |
Functional Keywords | gpcr, nanobody, membrane protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 63567.21 |
Authors | Wingler, L.M.,Staus, D.P.,Skiba, M.A.,McMahon, C.,Kleinhenz, A.L.W.,Lefkowitz, R.J.,Kruse, A.C. (deposition date: 2019-05-01, release date: 2020-02-19, Last modification date: 2023-10-11) |
Primary citation | Wingler, L.M.,Skiba, M.A.,McMahon, C.,Staus, D.P.,Kleinhenz, A.L.W.,Suomivuori, C.M.,Latorraca, N.R.,Dror, R.O.,Lefkowitz, R.J.,Kruse, A.C. Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR. Science, 367:888-892, 2020 Cited by PubMed: 32079768DOI: 10.1126/science.aay9813 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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