6C63

Crystal Structure of the Mango-II Fluorescent Aptamer Bound to TO1-Biotin

Summary for 6C63

Entry DOI	10.2210/pdb6c63/pdb
Descriptor	RNA (36-MER), RNA (32-MER), 4-[(3-{2-[(2-methoxyethyl)amino]-2-oxoethyl}-1,3-benzothiazol-3-ium-2-yl)methyl]-1-methylquinolin-1-ium, ... (4 entities in total)
Functional Keywords	fluorescent, rna, aptamer, g-quadruplex
Biological source	synthetic construct More
Total number of polymer chains	3
Total formula weight	36043.42
Authors	Trachman, R.J.,Ferre-D'Amare, A.R. (deposition date: 2018-01-17, release date: 2018-08-08, Last modification date: 2023-10-04)
Primary citation	Trachman 3rd., R.J.,Abdolahzadeh, A.,Andreoni, A.,Cojocaru, R.,Knutson, J.R.,Ryckelynck, M.,Unrau, P.J.,Ferre-D'Amare, A.R. Crystal Structures of the Mango-II RNA Aptamer Reveal Heterogeneous Fluorophore Binding and Guide Engineering of Variants with Improved Selectivity and Brightness. Biochemistry, 57:3544-3548, 2018 Cited by PubMed: 29768001 DOI: 10.1021/acs.biochem.8b00399 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.90002801531 Å)

Structure validation