6AM8
Engineered tryptophan synthase b-subunit from Pyrococcus furiosus, PfTrpB2B9 with Trp bound as E(Aex2)
Summary for 6AM8
| Entry DOI | 10.2210/pdb6am8/pdb |
| Descriptor | Tryptophan synthase beta chain 1, TRYPTOPHAN, SODIUM ION, ... (6 entities in total) |
| Functional Keywords | plp type ii, tryptophan synthase, engineered, allostery, biosynthetic protein |
| Biological source | Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) More |
| Total number of polymer chains | 4 |
| Total formula weight | 175589.98 |
| Authors | Buller, A.R.,van Roye, P. (deposition date: 2017-08-09, release date: 2018-05-16, Last modification date: 2023-11-15) |
| Primary citation | Buller, A.R.,van Roye, P.,Cahn, J.K.B.,Scheele, R.A.,Herger, M.,Arnold, F.H. Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble. J. Am. Chem. Soc., 140:7256-7266, 2018 Cited by PubMed: 29712420DOI: 10.1021/jacs.8b03490 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.83 Å) |
Structure validation
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