5MF6

Human Sirt6 in complex with activator UBCS039

Summary for 5MF6

Entry DOI	10.2210/pdb5mf6/pdb
Descriptor	NAD-dependent protein deacetylase sirtuin-6, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE, ZINC ION, ... (8 entities in total)
Functional Keywords	4-(pyridin-3-yl)-4, 5-dihydropyrrolo[1, 2-a]quinoxaline, dihydropyrrol, drug, hydrolase
Biological source	Homo sapiens (Human)
Cellular location	Nucleus, nucleoplasm : Q8N6T7
Total number of polymer chains	2
Total formula weight	70112.11
Authors	Steegborn, C.,You, W.,Kambach, C. (deposition date: 2016-11-17, release date: 2016-12-28, Last modification date: 2024-01-17)
Primary citation	You, W.,Rotili, D.,Li, T.M.,Kambach, C.,Meleshin, M.,Schutkowski, M.,Chua, K.F.,Mai, A.,Steegborn, C. Structural Basis of Sirtuin 6 Activation by Synthetic Small Molecules. Angew. Chem. Int. Ed. Engl., 56:1007-1011, 2017 Cited by PubMed: 27990725 DOI: 10.1002/anie.201610082 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.87 Å)

Structure validation