4RL0

Structural and mechanistic insights into NDM-1 catalyzed hydrolysis of cephalosporins

Summary for 4RL0

Entry DOI	10.2210/pdb4rl0/pdb
Descriptor	Beta-lactamase NDM-1, ZINC ION, (2R,5S)-5-[(carbamoyloxy)methyl]-2-[(R)-carboxy{[(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetyl]amino}methyl]-5,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, ... (4 entities in total)
Functional Keywords	ndm-1 antibiotic hydrolysis, hydrolase
Biological source	Klebsiella pneumoniae
Cellular location	Periplasm : C7C422
Total number of polymer chains	2
Total formula weight	52410.08
Authors	Feng, H.,Ding, J.,Zhu, D.,Liu, X.,Xu, X.,Zhang, Y.,Zang, S.,Wang, D.-C.,Liu, W. (deposition date: 2014-10-14, release date: 2014-11-19, Last modification date: 2024-02-28)
Primary citation	Feng, H.,Ding, J.,Zhu, D.,Liu, X.,Xu, X.,Zhang, Y.,Zang, S.,Wang, D.C.,Liu, W. Structural and Mechanistic Insights into NDM-1 Catalyzed Hydrolysis of Cephalosporins. J.Am.Chem.Soc., 136:14694-14697, 2014 Cited by PubMed: 25268575 DOI: 10.1021/ja508388e PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.3 Å)

Structure validation