4OW0
X-Ray Structural and Biological Evaluation of a Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-Like Proteases
Summary for 4OW0
Entry DOI | 10.2210/pdb4ow0/pdb |
Related | 4OVZ |
Descriptor | papain-like protease, ZINC ION, N-[(3-fluorophenyl)methyl]-1-[(1R)-1-naphthalen-1-ylethyl]piperidine-4-carboxamide, ... (6 entities in total) |
Functional Keywords | cov, coronavirus, hcov, human coronavirus, sars, severe acute respiratory syndrome, mers, middle east respiratory syndrome, plpro, papain-like protease; inhibitor, complex, dub, deubiquitinating enzyme, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | SARS coronavirus |
Cellular location | Non-structural protein 3: Host membrane ; Multi-pass membrane protein . Non-structural protein 4: Host membrane ; Multi-pass membrane protein . Non-structural protein 6: Host membrane ; Multi-pass membrane protein . Non-structural protein 7: Host cytoplasm, host perinuclear region . Non-structural protein 8: Host cytoplasm, host perinuclear region . Non-structural protein 9: Host cytoplasm, host perinuclear region . Non-structural protein 10: Host cytoplasm, host perinuclear region : P0C6U8 |
Total number of polymer chains | 2 |
Total formula weight | 72374.84 |
Authors | Baez-Santos, Y.M.,Mesecar, A. (deposition date: 2014-01-28, release date: 2014-04-23, Last modification date: 2023-11-15) |
Primary citation | Baez-Santos, Y.M.,Barraza, S.J.,Wilson, M.W.,Agius, M.P.,Mielech, A.M.,Davis, N.M.,Baker, S.C.,Larsen, S.D.,Mesecar, A.D. X-ray Structural and Biological Evaluation of a Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-like Proteases. J.Med.Chem., 57:2393-2412, 2014 Cited by PubMed: 24568342DOI: 10.1021/jm401712t PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
Download full validation report