4OW0
X-Ray Structural and Biological Evaluation of a Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-Like Proteases
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 901 |
| Chain | Residue |
| A | CYS190 |
| A | CYS193 |
| A | CYS225 |
| A | CYS227 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | binding site for residue S88 A 902 |
| Chain | Residue |
| A | TYR269 |
| A | GLN270 |
| A | TYR274 |
| A | THR302 |
| A | DMS903 |
| B | MET209 |
| B | GLY210 |
| B | PRO248 |
| B | TYR269 |
| A | LEU163 |
| A | GLY164 |
| A | ASP165 |
| A | PRO249 |
| A | TYR265 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue DMS A 903 |
| Chain | Residue |
| A | LYS158 |
| A | LEU163 |
| A | TYR269 |
| A | S88902 |
| A | HOH1057 |
| B | MET209 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 904 |
| Chain | Residue |
| A | GLN233 |
| B | VAL160 |
| B | GLU162 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue DMS A 905 |
| Chain | Residue |
| A | GLU125 |
| A | ASN178 |
| A | SER240 |
| A | SER241 |
| A | HOH1046 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 901 |
| Chain | Residue |
| B | CYS190 |
| B | CYS193 |
| B | CYS225 |
| B | CYS227 |
| site_id | AC7 |
| Number of Residues | 11 |
| Details | binding site for residue S88 B 902 |
| Chain | Residue |
| A | MET209 |
| A | GLY210 |
| A | PRO248 |
| A | TYR269 |
| B | GLY164 |
| B | ASP165 |
| B | PRO249 |
| B | TYR265 |
| B | TYR269 |
| B | TYR274 |
| B | THR302 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue DMS B 903 |
| Chain | Residue |
| A | GLY82 |
| A | SER86 |
| B | THR199 |
| B | HOH1022 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 74 |
| Details | Zinc finger: {"description":"C4-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00444","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16306590","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"For PL-PRO activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00444","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Active site: {"description":"For PL-PRO activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00444","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16306590","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00444","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
