4N6O

Crystal structure of reduced legumain in complex with cystatin E/M

Summary for 4N6O

Entry DOI	10.2210/pdb4n6o/pdb
Related	4N6L 4N6M 4N6N
Descriptor	legumain, cystatin-M, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
Functional Keywords	complex, cysteine protease, inhibitor, legumain, asparaginyl endopeptidase, reactive center loop, papain, cathepsin, cancer, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	48213.94
Authors	Dall, E.,Brandstetter, H. (deposition date: 2013-10-14, release date: 2015-02-11, Last modification date: 2023-11-15)
Primary citation	Dall, E.,Fegg, J.C.,Briza, P.,Brandstetter, H. Structure and mechanism of an aspartimide-dependent Peptide ligase in human legumain. Angew.Chem.Int.Ed.Engl., 54:2917-2921, 2015 Cited by PubMed: 25630877 DOI: 10.1002/anie.201409135 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation