4FQI

Crystal Structure of Fab CR9114 in Complex with a H5N1 influenza virus hemagglutinin

Summary for 4FQI

Entry DOI	10.2210/pdb4fqi/pdb
Related	4FNK 4FQH 4FQJ 4FQK 4FQL 4FQM 4FQV 4FQY
Descriptor	Hemagglutinin HA1, Hemagglutinin HA2, antibody CR9114 heavy chain, ... (9 entities in total)
Functional Keywords	neutralizing antibodies, antibody affinity, antigens, epitopes, glycosylation, hemagglutinin glycoproteins, immunoglobulin fab fragments, h5n1 subtype, influenza vaccines, avian flu, envelope protein, viral protein-immune system complex, viral protein/immune system
Biological source	Influenza A virus More
Total number of polymer chains	4
Total formula weight	107488.75
Authors	Dreyfus, C.,Wilson, I.A. (deposition date: 2012-06-25, release date: 2012-08-22, Last modification date: 2020-07-29)
Primary citation	Dreyfus, C.,Laursen, N.S.,Kwaks, T.,Zuijdgeest, D.,Khayat, R.,Ekiert, D.C.,Lee, J.H.,Metlagel, Z.,Bujny, M.V.,Jongeneelen, M.,van der Vlugt, R.,Lamrani, M.,Korse, H.J.,Geelen, E.,Sahin, O.,Sieuwerts, M.,Brakenhoff, J.P.,Vogels, R.,Li, O.T.,Poon, L.L.,Peiris, M.,Koudstaal, W.,Ward, A.B.,Wilson, I.A.,Goudsmit, J.,Friesen, R.H. Highly conserved protective epitopes on influenza B viruses. Science, 337:1343-1348, 2012 Cited by PubMed: 22878502 DOI: 10.1126/science.1222908 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.71 Å)

Structure validation