4AJP

Human LDHA in complex with 2-((4-(4-((3-((2-methyl-1,3-benzothiazol- 6yl)amino)-3-oxo-propyl)amino)-4-oxo-butyl)phenyl)methyl)propanedioic acid

Summary for 4AJP

Entry DOI	10.2210/pdb4ajp/pdb
Related	1I10 4AJ1 4AJ2 4AJ4 4AJE 4AJH 4AJI 4AJJ 4AJK 4AJL 4AJN 4AJO
Descriptor	L-LACTATE DEHYDROGENASE A CHAIN, {4-[4-({3-[(2-METHYL-1,3-BENZOTHIAZOL-6-YL)AMINO]-3-OXOPROPYL}AMINO)-4-OXOBUTYL]BENZYL}PROPANEDIOIC ACID, SULFATE ION, ... (5 entities in total)
Functional Keywords	oxidoreductase-inhibitor complex, fragment based lead generated inhibitors, oxidoreductase/inhibitor
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm: P00338
Total number of polymer chains	4
Total formula weight	153052.60
Authors	Tucker, J.A.,Brassington, C.,Caputo, A.,Ward, R.,Pearson, S.,Watson, M.,Tart, J.,Davies, G. (deposition date: 2012-02-16, release date: 2012-03-21, Last modification date: 2023-12-20)
Primary citation	Ward, R.,Brassington, C.,Breeze, A.L.,Caputo, A.,Critchlow, S.,Davies, G.,Goodwin, L.,Hassall, G.,Greenwood, R.,Holdgate, G.,Mrosek, M.,Norman, R.A.,Pearson, S.,Tart, J.,Tucker, J.A.,Vogtherr, M.,Whittaker, D.,Wingfield, J.,Winter, J.,Hudson, K. The Design and Synthesis of Novel Lactate Dehydrogenase a Inhibitors by Fragment-Based Lead Generation J.Med.Chem., 55:3285-, 2012 Cited by PubMed: 22417091 DOI: 10.1021/JM201734R PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.38 Å)

Structure validation