4AJP
Human LDHA in complex with 2-((4-(4-((3-((2-methyl-1,3-benzothiazol- 6yl)amino)-3-oxo-propyl)amino)-4-oxo-butyl)phenyl)methyl)propanedioic acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | L-LACTATE DEHYDROGENASE A CHAIN | polymer | 337 | 37432.3 | 4 | UniProt (P00338) Pfam (PF00056) Pfam (PF02866) | HOMO SAPIENS (HUMAN) | LDH-A, CELL PROLIFERATION-INDUCING GENE 19 PROTEIN, LDH MUSCLE SUBUNIT, LDH-M, RENAL CARCINOMA ANTIGEN NY-REN-59, LACTATE DEHYDROGENASE A |
| 2 | E, K, Q, T (A, B, C, D) | {4-[4-({3-[(2-METHYL-1,3-BENZOTHIAZOL-6-YL)AMINO]-3-OXOPROPYL}AMINO)-4-OXOBUTYL]BENZYL}PROPANEDIOIC ACID | non-polymer | 497.6 | 4 | Chemie (88N) | |||
| 3 | F, G, H, I, L... (A, B, C, D) | SULFATE ION | non-polymer | 96.1 | 11 | Chemie (SO4) | |||
| 4 | J, O, P (B, C) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 5 | W, X, Y, Z (A, B, C, D) | water | water | 18.0 | 394 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 331 (UniProt: P00338)
| PDB | External Database | Details |
|---|---|---|
| His 332 | - | expression tag |
| His 333 | - | expression tag |
| His 334 | - | expression tag |
| His 335 | - | expression tag |
| His 336 | - | expression tag |
| His 337 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 149729.4 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 3323.2 | |
| All* | Total formula weight | 153052.6 |
