3WWJ

Crystal structure of an engineered sitagliptin-producing transaminase, ATA-117-Rd11

Summary for 3WWJ

Entry DOI	10.2210/pdb3wwj/pdb
Related	3WWH 3WWI
Descriptor	(R)-amine transaminase, PYRIDOXAL-5'-PHOSPHATE (3 entities in total)
Functional Keywords	transaminase, amine-pyruvate aminotransferase, pyridoxal-5'-phosphate, multi-domain protein (alpha and beta), fold class iv plp-dependent enzyme, transferase
Biological source	Arthrobacter sp. KNK168
Total number of polymer chains	12
Total formula weight	442250.32
Authors	Guan, L.J.,Ohtsuka, J.,Okai, M.,Miyakawa, T.,Mase, T.,Zhi, Y.,Hou, F.,Ito, N.,Yasohara, Y.,Tanokura, M. (deposition date: 2014-06-18, release date: 2015-08-12, Last modification date: 2018-11-21)
Primary citation	Guan, L.J.,Ohtsuka, J.,Okai, M.,Miyakawa, T.,Mase, T.,Zhi, Y.,Hou, F.,Ito, N.,Iwasaki, A.,Yasohara, Y.,Tanokura, M. A new target region for changing the substrate specificity of amine transaminases. Sci Rep, 5:10753-10753, 2015 Cited by PubMed: 26030619 DOI: 10.1038/srep10753 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation