3W2T
Crystal structure of human depiptidyl peptidase IV (DPP-4) in complex with vildagliptin
Summary for 3W2T
| Entry DOI | 10.2210/pdb3w2t/pdb |
| Descriptor | Dipeptidyl peptidase 4, beta-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total) |
| Functional Keywords | alpha/beta, beta-propeller, hydrolase, aminopeptidase, serine protease, secreted, signal-anchor, transmembrane, diabetes, glycoprotein, cell membrane, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 2 |
| Total formula weight | 176942.22 |
| Authors | Kishida, H.,Nabeno, M.,Miyaguchi, I.,Tanaka, Y.,Katou, R.,Akahoshi, F. (deposition date: 2012-12-04, release date: 2013-05-15, Last modification date: 2023-11-08) |
| Primary citation | Nabeno, M.,Akahoshi, F.,Kishida, H.,Miyaguchi, I.,Tanaka, Y.,Ishii, S.,Kadowaki, T. A comparative study of the binding modes of recently launched dipeptidyl peptidase IV inhibitors in the active site Biochem.Biophys.Res.Commun., 434:191-196, 2013 Cited by PubMed: 23501107DOI: 10.1016/j.bbrc.2013.03.010 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.36 Å) |
Structure validation
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