3W2T
Crystal structure of human depiptidyl peptidase IV (DPP-4) in complex with vildagliptin
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Dipeptidyl peptidase 4 | polymer | 740 | 85880.0 | 2 | UniProt (P27487) Pfam (PF00930) Pfam (PF00326) In PDB | Homo sapiens (human) | ADABP, Adenosine deaminase complexing protein 2, ADCP-2, Dipeptidyl peptidase IV, DPP IV, T-cell activation antigen CD26, TP103, Dipeptidyl peptidase 4 membrane form, Dipeptidyl peptidase IV membrane form, Dipeptidyl peptidase 4 soluble form, Dipeptidyl peptidase IV soluble form |
2 | C, G | beta-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 2 | In PDB GlyTouCan (G61843VN) | |||
3 | D, E, F, H, I... | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 6 | In PDB GlyTouCan (G42666HT) | |||
4 | A, B | 2-{[(1r,3s,5R,7S)-3-hydroxytricyclo[3.3.1.1~3,7~]decan-1-yl]amino}-1-{(2S)-2-[(E)-iminomethyl]pyrrolidin-1-yl}ethan-1-o ne | non-polymer | 305.4 | 2 | Chemie (LF7) | |||
5 | A, B | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
6 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) | |||
7 | water | water | 18.0 | 1027 | Chemie (HOH) |
Sequence modifications
A, B: 33 - 766 (UniProt: P27487)
PDB | External Database | Details |
---|---|---|
His 767 | - | expression tag |
His 768 | - | expression tag |
His 769 | - | expression tag |
His 770 | - | expression tag |
His 771 | - | expression tag |
His 772 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 171760.1 | |
Branched | Number of molecules | 8 |
Total formula weight | 3281.1 | |
Non-Polymers* | Number of molecules | 9 |
Total formula weight | 1901.1 | |
All* | Total formula weight | 176942.2 |