3VDX

Structure of a 16 nm protein cage designed by fusing symmetric oligomeric domains

Summary for 3VDX

Entry DOI	10.2210/pdb3vdx/pdb
Related	4D9J
Descriptor	Designed 16nm tetrahedral protein cage containing Non-haem bromoperoxidase BPO-A2 and Matrix protein 1 (1 entity in total)
Functional Keywords	protein design, bionanotechnology, protein assembly, symmetry, biomaterials, de novo protein
Biological source	Streptomyces aureofaciens More
Cellular location	Virion membrane ; Peripheral membrane protein ; Cytoplasmic side : P03485
Total number of polymer chains	3
Total formula weight	150793.24
Authors	Lai, Y.-T.,Cascio, D.,Yeates, T.O. (deposition date: 2012-01-06, release date: 2012-06-20, Last modification date: 2023-09-13)
Primary citation	Lai, Y.T.,Cascio, D.,Yeates, T.O. Structure of a 16-nm cage designed by using protein oligomers. Science, 336:1129-1129, 2012 Cited by PubMed Abstract: Designing protein molecules that will assemble into various kinds of ordered materials represents an important challenge in nanotechnology. We report the crystal structure of a 12-subunit protein cage that self-assembles by design to form a tetrahedral structure roughly 16 nanometers in diameter. The strategy of fusing together oligomeric protein domains can be generalized to produce other kinds of cages or extended materials. PubMed: 22654051 DOI: 10.1126/science.1219351 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.002 Å)

Structure validation