3V6O

Leptin Receptor-antibody complex

Summary for 3V6O

Entry DOI	10.2210/pdb3v6o/pdb
Descriptor	Leptin receptor, Monoclonal antibody 9F8 fab fragment Heavy chain, Monoclonal antibody 9F8 fab fragment Light chain, ... (9 entities in total)
Functional Keywords	receptor-antibody complex, cytokine receptor, antibody fab fragment, immunoglobulin fold, leptin receptor-antibody complex, immune system
Biological source	Homo sapiens (human) More
Total number of polymer chains	6
Total formula weight	144456.21
Authors	Carpenter, B.,Hemsworth, G.R.,Ross, R.J.,Artymiuk, P.J. (deposition date: 2011-12-20, release date: 2012-03-14, Last modification date: 2023-12-27)
Primary citation	Carpenter, B.,Hemsworth, G.R.,Wu, Z.,Maamra, M.,Strasburger, C.J.,Ross, R.J.,Artymiuk, P.J. Structure of the human obesity receptor leptin-binding domain reveals the mechanism of leptin antagonism by a monoclonal antibody. Structure, 20:487-497, 2012 Cited by PubMed: 22405007 DOI: 10.1016/j.str.2012.01.019 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation