3RXW
KPC-2 carbapenemase in complex with PSR3-226
Summary for 3RXW
| Entry DOI | 10.2210/pdb3rxw/pdb |
| Related | 3RXX |
| Descriptor | Carbepenem-hydrolyzing beta-lactamase KPC, (2S,3R)-4-(2-amino-2-oxoethoxy)-3-(dihydroxy-lambda~4~-sulfanyl)-3-methyl-4-oxo-2-{[(1E)-3-oxoprop-1-en-1-yl]amino}butanoic acid, CITRIC ACID, ... (4 entities in total) |
| Functional Keywords | inhibitor, beta-lactamase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Klebsiella pneumoniae |
| Total number of polymer chains | 1 |
| Total formula weight | 28508.94 |
| Authors | Ke, W.,van den Akker, F. (deposition date: 2011-05-10, release date: 2012-03-21, Last modification date: 2023-09-13) |
| Primary citation | Ke, W.,Bethel, C.R.,Papp-Wallace, K.M.,Pagadala, S.R.,Nottingham, M.,Fernandez, D.,Buynak, J.D.,Bonomo, R.A.,van den Akker, F. Crystal structures of KPC-2 {beta}-lactamase in complex with 3-nitrophenyl boronic acid and the penam sulfone PSR-3-226. Antimicrob.Agents Chemother., 56:2713-2718, 2012 Cited by PubMed: 22330909DOI: 10.1128/AAC.06099-11 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.26 Å) |
Structure validation
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