3OG7
B-Raf Kinase V600E oncogenic mutant in complex with PLX4032
Summary for 3OG7
Entry DOI | 10.2210/pdb3og7/pdb |
Descriptor | AKAP9-BRAF fusion protein, N-(3-{[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)propane-1-sulfonamide (3 entities in total) |
Functional Keywords | b-raf, braf, proto-oncogene, v600e, kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 66445.41 |
Authors | Zhang, Y.,Zhang, K.Y.,Zhang, C. (deposition date: 2010-08-16, release date: 2010-09-22, Last modification date: 2024-02-21) |
Primary citation | Bollag, G.,Hirth, P.,Tsai, J.,Zhang, J.,Ibrahim, P.N.,Cho, H.,Spevak, W.,Zhang, C.,Zhang, Y.,Habets, G.,Burton, E.A.,Wong, B.,Tsang, G.,West, B.L.,Powell, B.,Shellooe, R.,Marimuthu, A.,Nguyen, H.,Zhang, K.Y.,Artis, D.R.,Schlessinger, J.,Su, F.,Higgins, B.,Iyer, R.,D'Andrea, K.,Koehler, A.,Stumm, M.,Lin, P.S.,Lee, R.J.,Grippo, J.,Puzanov, I.,Kim, K.B.,Ribas, A.,McArthur, G.A.,Sosman, J.A.,Chapman, P.B.,Flaherty, K.T.,Xu, X.,Nathanson, K.L.,Nolop, K. Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma. Nature, 467:596-599, 2010 Cited by PubMed: 20823850DOI: 10.1038/nature09454 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.45 Å) |
Structure validation
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